Výsledky vyhledávání - "Nicole Clemann"

Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing

Autor: Manuela Jaklin, Nicole Clemann, Marcel Leist, Paul Barrow, Stefan Kustermann, Jitao David Zhang, Martin Ebeling

Publikováno v: Reproductive Toxicology. 98:286-298

Human induced pluripotent stem cells (hiPSC) were used to develop an assay format that may deliver information on teratogenicity of drugs. A human pluripotent stem cell scorecard panel was used to monitor the expression of 96 marker genes that are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a724ed9e847601e6e120e459059e69
https://doi.org/10.1016/j.reprotox.2020.10.011

Zobrazit plný text záznamu

Optimization of the TeraTox assay for preclinical teratogenicity assessment

Autor: Manuela Jaklin, Claudia McGinnis, Erich Kueng, Paul Barrow, Lisa Sach-Peltason, Marcel Leist, Stefan Kustermann, Jitao David Zhang, Nicole Schaefer, Nicole Clemann

Publikováno v: Toxicological Sciences

Teratogenicity poses severe threats to patient safety. Stem-cell-based in vitro systems are promising tools to predict human teratogenicity. However, current in vitro assays are limited because they either capture effects on a certain germ layer, or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb95219af3a197bc5805d486b9c288ab
https://doi.org/10.1101/2021.07.06.451364

Zobrazit plný text záznamu

Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2018 and 2019

Autor: Paul Barrow, Nicole Clemann

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 99

Details of embryo-fetal development (EFD) studies were compiled for all FDA drug approvals in 2018-19. EFD studies were performed for 82 % of approvals (84 % of small molecules and 70 % of biopharmaceuticals). Rats and rabbits were used for 84 % of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8abc0a0e023dd29eaf85a1d6a594c39
https://pubmed.ncbi.nlm.nih.gov/32593570

Zobrazit plný text záznamu

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Publikováno v: Journal of Medicinal Chemistry. 58:1358-1371

Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential for the treatment of psychiatric diseases including depression, fragile X syndrome (FXS), anxiety, obsessive-compulsive disorders, and levodopa induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f629d43eba9d48337f793d5244811596
https://doi.org/10.1021/jm501642c

Zobrazit plný text záznamu

Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests

Autor: Ingeborg Pohl, Horst Spielmann, Andrea Seiler, Susanne Bremer, K. Becker, Elke Genschow, Nicole Clemann, Gabriele Scholz

Publikováno v: Alternatives to Laboratory Animals. 32:209-244

A detailed report is presented on the performance of the embryonic stem cell test (EST) in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryotoxicity. Twenty coded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc72b467e9d1886a98149c5ef21dfdb
https://doi.org/10.1177/026119290403200305

Zobrazit plný text záznamu

Validation of the Postimplantation Rat Whole-embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests

Autor: Aldert H. Piersma, Elke Genschow, Andrea Seiler, Aart Verhoef, Angie Burns, Nigel A. Brown, Madeleine Brady, Marielle Q I Spanjersberg, Horst Spielmann, Nicole Clemann

Publikováno v: Alternatives to Laboratory Animals. 32:275-307

A detailed report is presented on the performance of the postimplantation rat whole-embryo culture (WEC) test in a European Centre for the Validation of Alternative Methods (ECVAM)-sponsored formal validation study on three in vitro tests for embryot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67d5c91a6f07a4f37728c8d219e62ef
https://doi.org/10.1177/026119290403200307

Zobrazit plný text záznamu

The ECVAM International Validation Study on In Vitro Embryotoxicity Tests: Results of the Definitive Phase and Evaluation of Prediction Models

Autor: Nigel A. Brown, Horst Spielmann, Nicole Clemann, Gabriele Scholz, Susanne Bremer, Madeleine Brady, Hannele Huuskonen, Francoise Paillard, Andrea Seiler, Aldert H. Piersma, Elke Genschow, K. Becker

Publikováno v: Alternatives to Laboratory Animals. 30:151-176

From 1996 to 2000, ZEBET (Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments at the BgVV, Berlin, Germany) coordinated the European Centre for the Validation of Alternative Methods (ECVAM) prevalidation and validatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59b40af707b3d62720d09d7ff765c56b
https://doi.org/10.1177/026119290203000204

Zobrazit plný text záznamu

The embryonic stem cell test for the early selection of pharmaceutical compounds

Autor: Nicole Clemann, Heinrich Bürgin, Sonia Whitlow

Publikováno v: ALTEX. 24(1)

Potential teratogenicity is a major consideration in the development of pharmaceutical substances. Currently its assessment involves large numbers of animal tests at high cost. This study assessed the feasibility of using the embryonic stem cell test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dde60094b077f055bd245b4301073f
https://pubmed.ncbi.nlm.nih.gov/17361315

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání