Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicole C. Fay"'
Autor:
Radhika C. Desai, Hyo Jin Kim, Julia D. Mackay, Weijun Feng, Randall J. Mrsny, Lisa Song, Linh P. Nyugen, Nicole C. Fay, Mahmood Tahir, Sally Postlethwaite, Apurva Chandalia, Baby Periyanayaki Muthusamy, Keyi Liu, Michael P. Coyle, Olson Charles, Elbert Seto, Tom Hunter, Khushdeep Mangat, Alistair Taverner, Minji Seung, Aatif Alam, Maziyar Saberi
Publikováno v:
J Immunol
IL-10 is a potent anti-inflammatory cytokine capable of suppressing a number of proinflammatory signals associated with intestinal inflammatory diseases, such as ulcerative colitis and Crohn's disease. Clinical use of human IL-10 (hIL-10) has been li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcacdc98e95024eef8eb40f1c5cc0b2a
https://doi.org/10.4049/jimmunol.2000848
https://doi.org/10.4049/jimmunol.2000848
Membrane Association Transforms an Inert Anti-TCRβ Fab’ Ligand into a Potent T Cell Receptor Agonist
Autor:
Nicole C. Fay, Jenny J. Lin, Michael P. Coyle, Kiera B. Wilhelm, Katherine N. Alfieri, Shalini T. Low-Nam, Jay T. Groves, Geoff P. O’Donoghue
Publikováno v:
Biophysical Journal. 118:2879-2893
The natural peptide-major histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet capable of activating T cells at single-molecule levels when membrane-associated. This distinctive feature stems from the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a63ff2f2bdcb881d31b44d6af2cf18
https://doi.org/10.1016/j.bpj.2020.04.018
https://doi.org/10.1016/j.bpj.2020.04.018
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30704 (2012)
Activation of T cell receptor (TCR) by antigens occurs in concert with an elaborate multi-scale spatial reorganization of proteins at the immunological synapse, the junction between a T cell and an antigen-presenting cell (APC). The directed movement
Externí odkaz:
https://doaj.org/article/3668c393012c4674bcea30fe5e9a4d72
Autor:
Nicole C. Fay, Shalini T. Low-Nam, Geoff P. O’Donoghue, Rafal M. Pielak, Jenny J. Lin, Jay T. Groves, Katherine N. Alfieri
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 46
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 46
Significance Antigen discrimination by T cells is based on subtle differences in binding of the T cell receptor (TCR) for its peptide major histocompatibility complex (pMHC) ligand. While such binding characteristics are readily mapped with great pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e663e557ce350908ed09021d4e7e129
https://pubmed.ncbi.nlm.nih.gov/29087297
https://pubmed.ncbi.nlm.nih.gov/29087297
Autor:
Geoff P. O’Donoghue, Yan Yu, Niña G. Caculitan, Eulanca Y. Liu, Nicole C. Fay, Hiroyuki Kai, Theobald Lohmüller, Jay T. Groves
Publikováno v:
Nano Letters
Here we introduce a form of chromatography that can be imposed on the membrane of a living cell. A cell–cell signaling interaction is reconstituted in a hybrid live cell-supported membrane junction. The chromatographic material consists of a hexago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147426b33a5c9684ef78ebeec47db4c1
https://doi.org/10.1021/nl404514e
https://doi.org/10.1021/nl404514e
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773:1583-1588
Using fluorescence microscopy we have tracked the cellular binding, surface motion, and internalization of polyarginine and polyethylenimine, cationic ligands used for gene and protein delivery. Each ligand was complexed with a quantum dot to provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68fcf0c000b90d69cfd4a1d53eb2a5c
https://doi.org/10.1016/j.bbamcr.2007.07.009
https://doi.org/10.1016/j.bbamcr.2007.07.009
Publikováno v:
Biophysical Journal. 106(2):520a-521a
T cells use T cell receptors (TCRs) to robustly discern extremely low numbers of agonist peptide amidst a myriad of background peptides. The costimulatory receptor CD28 on the T cell surface engages CD80 on the antigen presenting cell to enhance the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4280540a286e0a5a3a067c4990ed57ac
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro. 2(10)
The intracellular vesicle-mediated degradation of extracellular cargo is an essential cellular function. Using two-color single particle tracking fluorescence microscopy, we have probed the intracellular degradation of low-density lipoprotein (LDL) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb27bf42415dad07531a508c02cc451
https://pubmed.ncbi.nlm.nih.gov/20852797
https://pubmed.ncbi.nlm.nih.gov/20852797
Publikováno v:
Biophysical Journal. 104:119a
T cells are able to robustly discern extremely low numbers of agonist peptide amidst a myriad of background peptides. Costimulation of CD28 on the T cell by CD80 on the antigen presenting cell is known to enhance the sensitivity of this recognition p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269f3bc3bbf24ee4851739619560b111
https://doi.org/10.1016/j.bpj.2012.11.686
https://doi.org/10.1016/j.bpj.2012.11.686
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:2039
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7893c1005640d1971568c308394edc2
https://doi.org/10.1016/j.bbamcr.2008.05.012
https://doi.org/10.1016/j.bbamcr.2008.05.012