Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Nicole C Walsh"'
Autor:
Frederick R Roberts, Clinton Hupple, Elaine Norowski, Nicole C Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M Van Dessel, Agata Jurczyk, David M Harlan, Dale L Greiner, Rita Bortell, Chaoxing Yang
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178641 (2017)
Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients, imaging technology to visualize pancreas inflammatio
Externí odkaz:
https://doaj.org/article/dcdb65ec0f2844ffb919749025c32f45
Autor:
Alvin J M Ng, Mannu K Walia, Monique F Smeets, Anthony J Mutsaers, Natalie A Sims, Louise E Purton, Nicole C Walsh, T John Martin, Carl R Walkley
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005160 (2015)
RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS patients have a highly incre
Externí odkaz:
https://doaj.org/article/bb83b1c5ea104daab3ac3decd12cd2de
Autor:
Amanda J. Fosang, Zerina Lokmic, Stephanie J. Gauci, Eunice R. Lee, Suzanne B. Golub, Liliana Tatarczuch, Danny Chan, Eleanor J. Mackie, Nicole C. Walsh, Heather Stanton, Christopher B. Little, Natalie A. Sims
Publikováno v:
Matrix Biology. 83:77-96
Cartilage remodelling and chondrocyte differentiation are tightly linked to angiogenesis during bone development and endochondral ossification. To investigate whether collagenase-mediated cleavage of the major cartilage collagen (collagen II) plays a
Autor:
Anand Palani, Min Lu, Jennifer O'Neil, Christopher Brynczka, Lisa Nogle, Amy C. Doty, Christian Fischer, Hai-Young Kim, Abdelghani Achab, Adam Beard, Nicole C. Walsh, Matthew Lloyd Childers, Kalyan Chakravarthy, Josep Saurí, Amy D. DeCastro, Peter W. Fan, Qinglin Pu, Richard A. Miller, Matthew J. Mitcheltree, Rachel L. Palte, Theodore A. Martinot, Hongjun Zhang, Symon Gathiaka, Roshi Afshar, Thomas W. Lyons, Spencer McMinn, Mangeng Cheng, Derun Li
Publikováno v:
Cancer Research. 81:297-297
Arginase overexpression has been associated with poor survival rates in advanced cancer patients treated with Keytruda. High levels of Arginase may lead to a depletion of arginine within the tumor microenvironment, inhibiting the immune response. Thu
Autor:
Michael A. Brehm, Laurie L. Kenney, Sonal Jangalwe, Nicole C. Walsh, Ken-Edwin Aryee, Leonard D. Shultz, Dale L. Greiner
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease. 12:187-215
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have become increasingly important as small, preclinical animal models for the study of human diseases. Since the description of immunodeficient mice bea
Publikováno v:
Osteoarthritis and Cartilage. 24:1047-1053
Summary Objectives Using a mouse surgical model of post-traumatic osteoarthritis (OA), we sought to determine if muscle function is altered following acute joint injury and whether this relates to OA progression. Design Male C57BL/6 mice underwent su
Autor:
Catherine A. Manning, Melissa M. Matzelle, J Li, Nicole C. Walsh, Vicki Rosen, Ellen M. Gravallese, Alice T. Shaw, Rebecca Baum, Yukiko Maeda, S. Karmakar
Publikováno v:
Scandinavian Journal of Rheumatology. 45:379-383
Inflammation in diseases such as rheumatoid arthritis (RA) stimulates osteoclast-mediated articular bone erosion and inhibits osteoblast-mediated bone formation, leading to a net loss of bone. Pro-inflammatory cytokines and antagonists of the Wnt sig
Publikováno v:
Bone. 72:34-42
To define their gene expression and function, osteocytes are commonly isolated and purified by fluorescence-activated cell sorting (FACS) from mice expressing GFP directed by the dentin matrix protein 1 (Dmp1) promoter (DMP1-GFP). These cells express
Autor:
Aleksei Lulla, Linda Hueston, Lara J. Herrero, Suresh Mahalingam, Weiqiang Chen, Natalie A. Sims, Andres Merits, Suan-Sin Foo, Adam Taylor, Nicole C. Walsh, Mark R. Forwood
Publikováno v:
Journal of Virology. 89:581-593
The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development of therapeutic intervention strategies. While there has been significant progress in defining the patho
Autor:
Nicole C. Walsh, Elaine Norowski, Chaoxing Yang, Frederick R Roberts, Rita Bortell, Natalia Przewozniak, Filia M Van Dessel, Dale L. Greiner, Clinton Hupple, David M. Harlan, Agata Jurczyk, Ken-Edwin Aryee
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 6, p e0178641 (2017)
PLoS ONE, Vol 12, Iss 6, p e0178641 (2017)
Background/aims Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients, imaging technology to visualize panc