Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

Autor: Nicole C McKnight, Yun Zhong, Mitchell S Wold, Shiaoching Gong, Greg R Phillips, Zhixun Dou, Yanxiang Zhao, Nathaniel Heintz, Wei-Xing Zong, Zhenyu Yue

Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004626 (2014)

Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose dist

Externí odkaz: https://doaj.org/article/51ac15d136a3420aa4e5c1812c95eb5b

Queuine, a bacterial derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration

Autor: Nicole C. McKnight, Antoine Danchin, Patrice Garnier, Xavier Manière, Hélène Guillorit, Patricia Richard, Lucie Kozlowski

Growing evidence suggests that human gut bacteria, comprising the microbiome that communicates with the brain through the so-called ‘gut-brain-axis’, are linked to neurodegenerative disorders. Imbalances in the microbiome of Parkinson’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6e051aea5eb93232733c3847315a701
https://doi.org/10.1101/2021.01.20.427538

Coiling up with SCOC and WAC

Autor: Martina Wirth, Sharon A. Tooze, Justin Joachim, Nicole C. McKnight

Publikováno v: Autophagy. 8:1397-1400

Autophagy is a conserved and highly regulated catabolic pathway, transferring cytoplasmic components in autophagosomes to lysosomes for degradation and providing amino acids during starvation. In multicellular organisms autophagy plays an important r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d287b0a9d7fb99f5a46735a28acf79a
https://doi.org/10.4161/auto.21043

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

Autor: Philip East, Rebecca Roylance, Charles Swanton, Lina M. Obeid, Sharon A. Tooze, Neil P. Jones, Stefka D. Spassieva, Julian Downward, Andrew M. Hanby, Valerie Speirs, Andrew Rowan, Patricia Gorman, Alvin J.X. Lee, Barbara Nicke, Zoltan Szallasi, Nicolai Juul Birkbak, Nicole C. McKnight, Jil Sander, Maik Kschischo, David Endesfelder

Publikováno v: Lee, A J X, Roylance, R, Sander, J, Gorman, P, Endesfelder, D, Kschischo, M, Jones, N P, East, P, Nicke, B, Spassieva, S, Obeid, L M, Birkbak, N J, Szallasi, Z, McKnight, N C, Rowan, A J, Speirs, V, Hanby, A M, Downward, J, Tooze, S A & Swanton, C 2012, ' CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction ', Journal of Pathology, vol. 226, no. 3, pp. 482-494 . https://doi.org/10.1002/path.2998

Chromosomal instability (CIN) has been implicated in multidrug resistance and the silencing of the ceramide transporter, CERT, promotes sensitization to diverse cytotoxics. An improved understanding of mechanisms governing multidrug sensitization mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e806898d8d4d0658d862841867c15024
https://doi.org/10.1002/path.2998

Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer

Autor: M. Golam Mohi, Glenn J. Bubley, Bradley Smith, Ben G. Neel, David Masiello, Stevan P. Balk, Nicole C. McKnight

Publikováno v: Cancer Biology & Therapy. 6:195-201

Inhibition of the mammalian target of rapamycin (mTOR) signaling pathway is a potentially useful therapeutic strategy in the treatment of advanced prostate cancer. However mTOR antagonists used as single agents are not likely to result in dramatic cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87a4d91ec764c617db9681622c481e4
https://doi.org/10.4161/cbt.6.2.3588