Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicole Brimer"'
Autor:
Nicole Brimer, Scott Vande Pol
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010431 (2022)
High-risk human papillomavirus (HPV) infections induce squamous epithelial tumors in which the virus replicates. Initially, the virus-infected cells are untransformed, but expand in both number and area at the expense of uninfected squamous epithelia
Externí odkaz:
https://doaj.org/article/a0d9d599eb3f459f8a1f455655f49740
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008295 (2020)
The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomavirus (HPV) associated cancers, the neurodevelopment disorder Angelman Syndrome, and some cases of autism spectrum disorders. How E6AP recognizes its c
Externí odkaz:
https://doaj.org/article/68cdc774041a432aba597ed8c79391dc
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006781 (2017)
Papillomavirus E6 proteins bind to LXXLL peptide motifs displayed on targeted cellular proteins. Alpha genus HPV E6 proteins associate with the cellular ubiquitin ligase E6AP (UBE3A), by binding to an LXXLL peptide (ELTLQELLGEE) displayed by E6AP, th
Externí odkaz:
https://doaj.org/article/6d2416114c784452a63b7dc24775b5e8
Publikováno v:
Virology. 516:127-138
HPV E6 oncoproteins associate with cellular PDZ proteins. In addition to previously identified cellular PDZ proteins, we found association of the HPV16 E6 PBM with the Dystrophin Glycoprotein Complex, LRCC1, and SLC9A3R2. HPV18 E6 had additional asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9048359c97745dc871ca11819b707ae
https://doi.org/10.1016/j.virol.2018.01.003
https://doi.org/10.1016/j.virol.2018.01.003
Publikováno v:
Journal of Virology. 88:9927-9933
Bovine papillomavirus 1 E6 interacts with two similar proteins that regulate cell attachment and cell migration called paxillin (PXN) and HIC-5 (also known as HIC5, ARA55, HIC-5, TSC-5, and TGFB1I1). Despite the similarity between HIC-5 and paxillin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a65aa6da5475a17ed73d42dfe8ba8ac
https://doi.org/10.1128/jvi.00552-14
https://doi.org/10.1128/jvi.00552-14
Autor:
Nicole Brimer, Scott B. Vande Pol
Publikováno v:
Journal of Virology. 88:3027-3030
Cancer-associated human papillomaviruses (HPVs) express E6 oncoproteins that target the degradation of p53 and have a carboxy-terminal PDZ ligand that is required for stable episomal maintenance of the HPV genome. We find that the E6 PDZ ligand can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d88ea802f15ceb290699c53441b3919
https://doi.org/10.1128/jvi.02360-13
https://doi.org/10.1128/jvi.02360-13
Publikováno v:
Oncogene
Papillomavirus E6 oncoproteins associate with LXXLL motifs on target cellular proteins to alter their function. Using a proteomic approach, we found the E6 oncoproteins of cutaneous papillomaviruses Bovine Papillomavirus Type 1 (BPV-1) E6 and human p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b298dcd628db5293bf7732da4077b875
https://doi.org/10.1038/onc.2011.589
https://doi.org/10.1038/onc.2011.589
Publikováno v:
Journal of Biological Chemistry. 286:37932-37944
Paxillin and HIC5 are closely related adapter proteins that regulate cell migration and are tyrosine-phosphorylated by focal adhesion kinase (FAK). Paxillin, HIC5, and FAK tyrosine phosphorylation increase upon cell attachment and decrease upon detac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fb1a7f3e7383185a1ca7e1610bf398
https://doi.org/10.1074/jbc.m111.294504
https://doi.org/10.1074/jbc.m111.294504
Publikováno v:
Journal of Virology. 81:2231-2239
Oncoproteins from DNA tumor viruses associate with critical cellular proteins to regulate cell proliferation, survival, and differentiation.Human papillomavirus (HPV) E6 oncoproteins have been previously shown to associate with a cellular HECT domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9403d62eb2081f6271040834ac6ed52
https://doi.org/10.1128/jvi.01979-06
https://doi.org/10.1128/jvi.01979-06
Publikováno v:
Journal of Biological Chemistry. 282:9392-9400
MPP7, a previously uncharacterized member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, was found in a tripartite complex with DLG1 and LIN7A or LIN7C. MPP7 dimerizes with all three LIN7 family members (LIN7A, -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdd93775f2c4c3d59f906e8c86c2728
https://doi.org/10.1074/jbc.m610002200
https://doi.org/10.1074/jbc.m610002200