Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nicole Bernad"'
Autor:
Spyridon Papazacharias, Vassiliki Magafa, Nicole Bernad, George Pairas, Georgios A. Spyroulias, Jean Martinez, Paul Cordopatis
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2010 (2010)
A series of 7 new human/rat Corticotropin Releasing Hormone (h/r-CRH) analogues were synthesized. The induced alterations include substitution of Phe at position 12 with D-Phe, Leu at positions 14 and 15 with Aib and Met at positions 21 and 38 with C
Externí odkaz:
https://doaj.org/article/3f83686e654e46b88608536af3098f0e
Autor:
Sonia Cantel, Philippe Marin, Jean-Louis Banères, Gilbert Bergé, Karine Puget, Jean Martinez, Charlène Valmalle, Gilles Subra, Anne-Claire Coyne, Céline M'Kadmi, Jérémie Neasta, Jean-Claude Galleyrand, Valérie Daugé, Nicole Bernad, Jacky Marie, Didier Gagne, Eric Carnazzi, Marie-Lou Kemel
Publikováno v:
British Journal of Pharmacology. 173:1314-1328
Background and PurposeUsing an in-house bioinformatics programme, we identified and synthesized a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Here, we have studied its biological activity, in vitro and in vivo, and have identified it
Autor:
Marie-Françoise Lignon, Nicole Bernad, José Luis Martínez, Jean-Claude Galleyrand, Ana-Christina Lima-Leite, Pierre Fulcrand, Jean-Christophe Lallement
Publikováno v:
International Journal of Peptide and Protein Research. 44:348-356
In the course of our study concerning gastrin and cholecystokinin (CCK) receptors, we have synthesized and characterized a new labeled gastrin ligand, 125I-BH-[Leu15]-gastrin-(5-17) [(3-[125I]iodo-4-hydroxyphenyl)-propionyl-[Leu15]-gastrin-(5-17)]. B
Autor:
Laure di Malta, Jean Martinez, Nicole Bernad, Daniel Fourmy, Jean-Claude Galleyrand, Chantal Escrieut, Roya Poosti, Sandrine Silvente-Poirot, Didier Gagne
Publikováno v:
Scopus-Elsevier
It has previously been reported that the cholecystokinin analog JMV-180 behaves differently on the rat and the mouse cholecystokinin-A receptor (CCK-AR). In mice this analog acts as an agonist on low- and high-affinity sites of the CCK-AR, whereas in
Autor:
Annie Heitz, Michèle Cristau, Chantal Devin, Jean-Alain Fehrentz, Jean Martinez, Anne-Marie Artis-Noel, Nicole Bernad
Publikováno v:
Journal of Peptide Science. 5:176-184
Bombesin pseudo-peptide analogues containing a hydroxamide function on the C-terminal part of the molecule, e.g. H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOBzl 1 and H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOH 2 were synthesized. These compounds were tested
Autor:
M Llinares, Chantal Devin, Nicole Bernad, J Azay, José Luis Martínez, Jean-Alain Fehrentz, A. M. Noel-Artis, Olivier Chaloin
Publikováno v:
The Journal of Peptide Research. 53:275-283
Bombesin receptor antagonists are potential therapeutic agents due to their ability to act as inhibitors of cellular proliferation. On the basis of our hypothesis concerning the mechanism of action of gastrin associating an activating enzyme to the r
Autor:
Jean Martinez, Marie-Christine Galas, André Aumelas, Muriel Amblard, Nicole Bernad, Marie-Françoise Lignon, M. Rodriguez
Publikováno v:
European Journal of Medicinal Chemistry. 33:171-180
We reported earlier on the synthesis and biological activity at the CCK-B receptor of cyclized derivatives of CCK. These peptides, in which the positions 28 and 31 were replaced by lysine residues, were bridged by a succinyl moiety. To determine the
Autor:
Jean Martinez, Jean-Alain Fehrentz, J.‐C. Califano, Muriel Amblard, Nicole Bernad, Gilbert Bergé, Jean Castel, Laurent Goullieux
Publikováno v:
Scopus-Elsevier
The involvement of cholecystokinin receptors in the phenomenon of satiety has been the impetus for significant research efforts, leading to the design and synthesis of CCK-A selective agonists for the possible treatment of obesity. The Abbott laborat
Autor:
Jean Martinez, Nicole Bernad, Stephen A. Kolodziej, Gregory V. Nikiforovich, Garland R. Marshall, Bruce Nock
Publikováno v:
Biopolymers. 36:439-452
The sequence of a cholecystokinin (CCK) related peptide was modified to obtain analogues, which intereact selectively either with CCK-B, or with δ-opioid receptors. Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo(
Publikováno v:
Annals of the New York Academy of Sciences. 713:334-337