Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicole Bedke"'
Autor:
Jane Harper, Katherine J Adams, Giovanna Bossi, Debbie E Wright, Andrea R Stacey, Nicole Bedke, Ruth Martinez-Hague, Dan Blat, Laure Humbert, Hazel Buchanan, Gabrielle S Le Provost, Zoe Donnellan, Ricardo J Carreira, Samantha J Paston, Luise U Weigand, Martina Canestraro, Joseph P Sanderson, Sophie Botta Gordon-Smith, Kate L Lowe, Karolina A Rygiel, Alex S Powlesland, Annelise Vuidepot, Namir J Hassan, Brian J Cameron, Bent K Jakobsen, Joseph Dukes
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205491 (2018)
Robust preclinical testing is essential to predict clinical safety and efficacy and provide data to determine safe dose for first-in-man studies. There are a growing number of examples where the preclinical development of drugs failed to adequately p
Externí odkaz:
https://doaj.org/article/c3d7165394b5442098ed39f7073a5fbd
Autor:
Rocio T Martinez-Nunez, Victor P Bondanese, Fethi Louafi, Ana S Francisco-Garcia, Hitasha Rupani, Nicole Bedke, Stephen Holgate, Peter H Howarth, Donna E Davies, Tilman Sanchez-Elsner
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111659 (2014)
MicroRNAs are short non-coding single stranded RNAs that regulate gene expression. While much is known about the effects of individual microRNAs, there is now growing evidence that they can work in co-operative networks. MicroRNAs are known to be dys
Externí odkaz:
https://doaj.org/article/d6a89c9e62144854aee37d6b2d081383
Autor:
Nicole Bedke, David Sammut, Ben Green, Valia Kehagia, Patrick Dennison, Gisli Jenkins, Amanda Tatler, Peter H Howarth, Stephen T Holgate, Donna E Davies
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44580 (2012)
Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-β, influences interferon (IFN) production by pr
Externí odkaz:
https://doaj.org/article/b82d414dff97451b8bb768e3c0f7ae2e
Autor:
Patrick G. Holt, Nicole Bedke, Emily J. Swindle, Cornelia Blume, Donna E. Davies, Stephen T. Holgate, Deborah H. Strickland, Ruth Morris, Camelia Molnar, Graham Roberts
Publikováno v:
Journal of Immunological Methods
Dendritic cells (DCs) play a central role in regulating innate and adaptive immune responses. It is well accepted that their regulatory functions change over the life course. In order to study DCs function during early life it is important to charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eadcb3ec0880fc851847624bc254ca
https://eprints.soton.ac.uk/435812/
https://eprints.soton.ac.uk/435812/
Autor:
Debbie E. Wright, Bent K. Jakobsen, Tomasz Dobrzycki, Ruth Martinez-Hague, Luise U. Weigand, Ana Ribeiro, Nicole Bedke, Jane Harper, Sophie Botta Gordon-Smith, Samantha Paston, Laure Humbert, Dan Blat, Joseph Dukes, Andrea Stacey, Giovanna Bossi, Zoe Donellan, Martina Canestraro
Publikováno v:
Cancer Immunology Research. 7:A214-A214
Immune Mobilising Monoclonal TCRs Against Cancer (ImmTAC) molecules are a new class of bi-specific biologic specifically designed to recognize and eradicate cancer cells. ImmTAC molecules are composed of an affinity-enhanced T-cell receptor (TCR) fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fc78f248c4e5df91924dae9529c039
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a214
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a214
Autor:
Peter H. Howarth, Ben Green, Lena Uller, Nicole Bedke, Stephen T. Holgate, Donna E. Davies, Laurie Lau, Marina S. Leino, David Sammut
Publikováno v:
Thorax. 65:626-632
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that strongly activates dendritic cells and can initiate allergic inflammation. Since exposure to rhinovirus or double-stranded (ds) RNA (a surrogate of viral infection) induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84658eac3bbf510e15504d2891cabf5
https://doi.org/10.1136/thx.2009.125930
https://doi.org/10.1136/thx.2009.125930
Autor:
Nicole Bedke, Donna E. Davies, Natalie P. Smithers, Matthew Loxham, Maaike de Vries, Martijn C. Nawijn, Peter H. Howarth
Publikováno v:
European Respiratory Journal, 47(3), 783-791. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Therapeutic options to treat virus-induced asthma exacerbations are limited and urgently needed. Therefore, we tested Pim1 kinase as potential therapeutic target in human rhinovirus (HRV) infections. We hypothesised that inhibition of Pim1 kinase red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1a05e5e2374171fd9ddf256998d75e
https://pubmed.ncbi.nlm.nih.gov/26869670
https://pubmed.ncbi.nlm.nih.gov/26869670
Autor:
Patrick Dennison, David Sammut, Ben Green, Donna E. Davies, Stephen T. Holgate, Peter H. Howarth, Valia Kehagia, Amanda L. Tatler, Gisli Jenkins, Nicole Bedke
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44580 (2012)
PLoS ONE
PLoS ONE
Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-β, influences interferon (IFN) production by pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6195908853604ff9d7abd16924b2472
https://eprints.soton.ac.uk/346650/
https://eprints.soton.ac.uk/346650/
Autor:
Allison-Lynn Andrews, Nicole Bedke, Hannah Sawkins, Gemma Campbell-Harding, Stephen T. Holgate, Donna E. Davies
Publikováno v:
The Journal of allergy and clinical immunology. 131(3)
Background IL-13 is key mediator of allergic inflammation in asthmatic patients. We have previously shown that the decoy receptor IL-13 receptor (IL-13R) α2 attenuates responses of fibroblasts to IL-13. Because the expression of IL-13Rα2 can be reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8574f13ef675b4ba248afb4b40db8b6d
https://pubmed.ncbi.nlm.nih.gov/23069489
https://pubmed.ncbi.nlm.nih.gov/23069489
Autor:
Donna E. Davies, Nicole Bedke, Jeffrey A. Whitsett, Julian Legg, Hans Michael Haitchi, Stephen T. Holgate, Graham Roberts
Publikováno v:
B35. PATHOGENESIS AND CLINICAL ISSUES IN CYSTIC FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb76adccc5686df33862463b10e7e814
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2806
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2806