Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nicole Barucci"'
Autor:
Gregory H. Bird, J. J. Patten, William Zavadoski, Nicole Barucci, Marina Godes, Benjamin M. Moyer, Callum D. Owen, Paul DaSilva-Jardine, Donna S. Neuberg, Richard A. Bowen, Robert A. Davey, Loren D. Walensky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The continued emergence of highly pathogenic viruses, which either thwart immune- and small molecule-based therapies or lack interventions entirely, mandates alternative approaches, particularly for prompt and facile pre- and post-exposure p
Externí odkaz:
https://doaj.org/article/379e0f8e24a44fc788e840416e81045c
Autor:
Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf
Autor:
Qing Zhang, William J. Zavadoski, Robert J. Aiello, M.C. Holt, Nicole Barucci, Jim Valentine, A.J. Stein, Vishwas M. Paralkar, Stéphane De Lombaert, Daniel R. Goldberg, Patricia Bourassa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:413-419
As a follow-up to the discovery of our spirocyclic proline-based TPH1 inhibitor lead, we describe the optimization of this scaffold. Through a combination of X-ray co-crystal structure guided design and an in vivo screen, new substitutions in the lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d832bfe964546651027bc5ad2f1478f
https://doi.org/10.1016/j.bmcl.2016.12.053
https://doi.org/10.1016/j.bmcl.2016.12.053
Autor:
Nicole Barucci, Stéphane De Lombaert, Vishwas M. Paralkar, Jim Valentine, William J. Zavadoski, Patricia Bourassa, Robert J. Aiello, A.J. Stein, Daniel R. Goldberg, Qing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2855-2860
An increasing number of diseases have been linked to a dysfunctional peripheral serotonin system. Given that tryptophan hydroxylase 1 (TPH1) is the rate limiting enzyme in the biosynthesis off serotonin, it represents an attractive target to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1fd6da7a2d3eccaf3ce69f8c5f867b
https://doi.org/10.1016/j.bmcl.2016.04.057
https://doi.org/10.1016/j.bmcl.2016.04.057
Autor:
Patricia Bourassa, Nicole Barucci, Stéphane De Lombaert, William J. Zavadoski, Daniel R. Goldberg, Qing Zhang, Robert J. Aiello, James J. Valentine, Vishwas M. Paralkar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1124-1129
The central role of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) as a neurotransmitter with important cognitive and behavioral functions is well known. However, 5-HT produced in the brain only accounts for approximately 5% of the tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ee42e411b02d02f0ced871cd344fd2
https://doi.org/10.1016/j.bmcl.2016.01.064
https://doi.org/10.1016/j.bmcl.2016.01.064
Autor:
Jeffrey A, Pfefferkorn, Meihua, Tu, Kevin J, Filipski, Angel, Guzman-Perez, Jianwei, Bian, Gary E, Aspnes, Matthew F, Sammons, Wei, Song, Jian-Cheng, Li, Christopher S, Jones, Leena, Patel, Tim, Rasmusson, Dongxiang, Zeng, Kapil, Karki, Michael, Hamilton, Richard, Hank, Karen, Atkinson, John, Litchfield, Robert, Aiello, Levenia, Baker, Nicole, Barucci, Patricia, Bourassa, Francis, Bourbonais, Francis, Bourbounais, Theresa, D'Aquila, David R, Derksen, Margit, MacDougall, Alan, Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7100-7105
Glucokinase activators represent a promising potential treatment for patients with Type 2 diabetes. Herein, we report the identification and optimization of a series of novel indazole and pyrazolopyridine based activators leading to the identificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decea8e508a8ec84ae478bd0cc878d20
https://doi.org/10.1016/j.bmcl.2012.09.082
https://doi.org/10.1016/j.bmcl.2012.09.082
Autor:
Jing Chen, Spiros Liras, Manthena V.S. Varma, Judith L. Treadway, Martha L. Minich, Laurel Sweet, John D. Knafels, Karen Atkinson, Nahor Haddish-Berhane, Angel Guzman-Perez, Benjamin D. Stevens, Alan Robertson, Sharad B. Murdande, David B. Duignan, Mark Ammirati, Timothy P. Rolph, William J. Zavadoski, Christopher S. Jones, Patricia Bourassa, Jeffrey A. Pfefferkorn, John Litchfield, Lili Yao, Kevin J. Filipski, Margit MacDougall, Levenia Baker, John C. Pettersen, Theresa D’Aquila, Ayman El-Kattan, Bo Feng, Francis Bourbonais, Meihua Tu, Robert J. Aiello, Gary Erik Aspnes, Jianwei Bian, David R. Derksen, Paul DaSilva-Jardine, Beijing Tan, James A. Landro, Over Cabrera, Rachel E. Kosa, Hud Lawrence Risley, Shenping Liu, Amanda L. Lapworth, Nicole Barucci
Publikováno v:
Journal of Medicinal Chemistry. 55:1318-1333
Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric activators of this enzyme represent a promising opportunity for the treatment of type 2 diabetes. Systemically acting glucokinase activators (liver and pancreas) hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4c2ff700899b62627c8e68d3696bfd
https://doi.org/10.1021/jm2014887
https://doi.org/10.1021/jm2014887
Autor:
Nicole Barucci, Herbert Ogutu, Laurel Sweet, Ronda Ott-Morgan, Louis-David Cantin, Yaxin Li, James N. Livingston, Philip Wickens, Lei Zhu, Sidney X. Liang, Jennifer Burke, Timothy B. Lowinger, Zhonghua Zhang, Bullock William H, Michelle Daly, Robert Schoenleber, Lynn Decarr, Steven Magnuson, Adrian Tersteegen, Ann Gore-Willse, Ellalahewage Kumarasinghe, Alan Olague, Jian Zhu, Marina Breuhaus, David E. Gunn, Margit L. MacDougall, Thomas H. Claus, Helana Hoover-Litty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2869-2873
Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3af4ab257fadf82282810fb965d1d86
https://doi.org/10.1016/j.bmcl.2007.02.061
https://doi.org/10.1016/j.bmcl.2007.02.061
Autor:
William J. Zavadoski, Daniel R. Goldberg, Patricia-Ann Bourassa, Nicole Barucci, Stéphane De Lombaert, Qing Zhang, Robert J. Aiello, Jeffrey Dubins, Vishwas Paralkar
Publikováno v:
4.3 Pulmonary Circulation and Pulmonary Vascular Disease.
Pulmonary arterial hypertension (PAH) is a progressive disease defined by an elevation in pulmonary arterial pressure with extensive pulmonary vascular remodeling and perivascular mast cell accumulation. While the exact etiology of the disease is unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb928e7ba61ce63c065b799da12796f4
https://doi.org/10.1183/13993003.congress-2015.pa4909
https://doi.org/10.1183/13993003.congress-2015.pa4909
Autor:
Timothy P. Rolph, Jiangli Yan, Levenia Baker, Alan Robertson, Vinicius Bonato, Jeffrey A. Pfefferkorn, Paul A. Amor, Jeff K. Trimmer, Theresa D’Aquila, Guoyun Bai, Derek M. Erion, Qingyun Yan, Yimin Zhu, Nicole Barucci, Matthew Gorgoglione, Nicholas B. Vera, Ronald W. Clark, Julie Purkal, Robert J. Aiello, Amanda L. Lapworth, Trenton T. Ross, Guodong Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
PLoS ONE
PLoS ONE
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ea8ae1d1d8d29924dda2ab8dfedf2
http://europepmc.org/articles/PMC4032240?pdf=render
http://europepmc.org/articles/PMC4032240?pdf=render