Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

Autor: Li Chen, Jacqueline Mudd, Michael Ittmann, Carol J. Bult, Amanda R. Kirane, Jelena Randjelovic, Stephen Scott, Yige Wu, Li Ding, Vashisht G. Yennu-Nanda, Jing Wang, Christopher D. Lanier, Maihi Fujita, Emilio Cortes-Sanchez, Sienna Rocha, Susan G. Hilsenbeck, Kian-Huat Lim, Fernanda Martins Rodrigues, Jill Rubinstein, Nicholas Mitsiades, Haiyin Lin, Jayamanna Wickramasinghe, Andrew Butterfield, Bryan E. Welm, Alana L. Welm, Jose P. Zevallos, Jason Held, Nicole B. Coggins, Song Cao, Yuanxin Xi, Brenda C. Timmons, Paul Lott, David Menter, Shunqiang Li, Tina Primeau, Fei Yang, Andrea Wang-Gillam, Ramaswamy Govindan, Dali Li, Brandi Davis-Dusenbery, Sara Seepo, Michael C. Wendl, Jeffrey Grover, Brian S. White, Clifford G. Tepper, Peter N. Robinson, Michael A. Davies, Zhengtao Chu, Michael W. Lloyd, Hua Sun, Xiaoshan Zhang, Tamara Stankovic, Dylan Fingerman, Anuj Srivastava, Luis G. Carvajal-Carmona, Don L. Gibbons, Lijun Yao, Rebecca Aft, Hongyong Zhang, Ismail Meraz, John DiGiovanna, Scott Kopetz, Ling Zhao, Guadalupe Polanco-Echeverry, Feng Chen, Jeremy Hoog, Matthew A. Wyczalkowski, George Xu, John D. Minna, Yi Xu, Julie Belmar, Xiaowei Xu, Luc Girard, Dennis A. Dean, Tijana Borovski, Chong-xian Pan, Cynthia X. Ma, Alexa Morales Arana, Yize Li, Turcin Saridogan, Steven B. Neuhauser, Sandra Scherer, Vicki Chin, Rose Tipton, David R. Gandara, Sherri R. Davies, Argun Akcakanat, Rajesh Patidar, Julie K. Schwarz, Soner Koc, Gao Boning, Michael Kim, Bryce P. Kirby, Yvonne A. Evrard, Hyunsil Park, Christian Frech, Chia-Kuei Mo, Ran Zhang, Brian A. Van Tine, Jonathan W. Reiss, Min Xiao, Xing Yi Woo, Tiffany Le, Ana Estrada, Xiaofeng Zheng, Jeffrey A. Moscow, Mourad Majidi, Nadezhda V. Terekhanova, Katherine Fuh, Erkan Yuca, Timothy A. Yap, Jianhua Zhang, Matthew J. Ellis, Shannon Westin, James H. Doroshow, Vito W. Rebecca, Moon S. Chen, Coya Tapia, Reyka G Jayasinghe, Jack A. Roth, Jithesh Augustine, Ryan C. Fields, Michae T. Tetzlaff, Michael T. Lewis, Kurt W. Evans, Ralph W. deVere White, Brian J. Sanderson, May Cho, Jeffrey H. Chuang, Tiffany Wallace, Ryan Jeon, Ted Toal, Matthew H. Bailey, Bert W. O'Malley, Katherine L. Nathanson, Qin Liu, Benjamin J. Raphael, Jingqin Luo, Salma Kaochar, Huiqin Chen, Rajasekharan Somasundaram, Daniel Cui Zhou, John F. DiPersio, Andrew V. Kossenkov, Bingliang Fang, Vanessa Jensen, Simone Zaccaria, Alexey Sorokin, Ai-Hong Ma, Sidharth V. Puram, Min Jin Ha, Meenhard Herlyn, R. Jay Mashl, Kelly Gale, Bingbing Dai, Lacey E. Dobrolecki, Chieh-Hsiang Yang, Funda Meric-Bernstam

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications

Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established the genomic landscapes of 536 pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a532801486680203051ed293ca8f82
https://doaj.org/article/e6286532f9bc487a87943a142621d7a3

Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRC

Autor: Nicole B. Coggins, Paul C. Lott, Luis G. Carvajal Carmona, David J. Segal, Henriette O'geen

Genome-wide association studies have identified numerous loci associated with increased risk for colorectal cancer (CRC), including 8q24.21 which contains a known enhancer of proto-oncogene MYC . However, the role of candidate functional SNP rs698326

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1c12cf56db4216b15d8ae10e49eae8d
https://doi.org/10.21203/rs.3.rs-667797/v1

Abstract 2972: Identifying clinically relevant molecular distinctions in gastric cancer development among US minorities to address cancer health disparities

Autor: Ana P. Estrada-Florez, Amanda Kirane, Javier Torres, May Cho, Luis G. Carvajal-Carmona, Ted Toal, Rasika Venkatesh, Sienna Rocha, Alexa Morales Arana, Hongyong Zhang, Paul Lott, Guadalupe Carvajal, Elizabeth Quino, Nicole B. Coggins

Publikováno v: Cancer Research. 81:2972-2972

Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. While overall incidence and mortality rates have dropped in recent decades, GC remains a significant health disparity in Hispanic/Latino Americans (HLAs) and in Asian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee08770311b00c0187c6408c70419d90
https://doi.org/10.1158/1538-7445.am2021-2972

Abstract B05: Comprehensive functional modeling of pan-cancer risk SNP rs6983267 in human CRC cells via scarless CRISPR/Cas9 genome editing

Autor: Nicole B. Coggins, Luis G. Carvajal-Carmona, Henriette O'Geen, David J. Segal

Publikováno v: Cancer Research. 80:B05-B05

With the continued emergence of genome-wide association study-identified risk loci for complex diseases as well as a sharp increase in the number of variants of uncertain significance (VUS) identified from patient sequencing, better methods are requi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a0b796030ecde5252d8915b69944067
https://doi.org/10.1158/1538-7445.camodels2020-b05

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance

Autor: David J. Segal, Luis G. Carvajal-Carmona, Nicole B. Coggins, Jacob Stultz, Henriette O'Geen

Publikováno v: Scientific reports, vol 7, iss 1
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports

With the continued emergence of risk loci from Genome-Wide Association studies and variants of uncertain significance identified from patient sequencing, better methods are required to translate these human genetic findings into improvements in publi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9989be7b32e1414cf721596646a9b8bd
https://escholarship.org/uc/item/43p8k494