Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nicole Appel"'
Autor:
Sahil Inamdar, Abhirami P. Suresh, Joslyn L. Mangal, Nathan D. Ng, Alison Sundem, Christopher Wu, Kelly Lintecum, Abhirami Thumsi, Taravat Khodaei, Michelle Halim, Nicole Appel, Madhan Mohan Chandra Sekhar Jaggarapu, Arezoo Esrafili, Jordan R. Yaron, Marion Curtis, Abhinav P. Acharya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is presented where glycolysis is inhibited in cancer cells
Externí odkaz:
https://doaj.org/article/1b742fa55db040f2888e0d48066e3a19
Autor:
John D. Christie, Nicole Appel, Hannah Canter, Jazmin Galvan Achi, Natalie M. Elliott, Ana Lemos de Matos, Lina Franco, Jacquelyn Kilbourne, Kenneth Lowe, Masmudur M. Rahman, Nancy Y. Villa, Joshua Carmen, Evelyn Luna, Joseph Blattman, Grant McFadden
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 539-554 (2021)
Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination
Externí odkaz:
https://doaj.org/article/ccbd0d437183457d9d022e1f440fa0a5
Autor:
Nancy.Y. Villa, Masmudur M. Rahman, Joseph. Mamola, Julia D’Isabella, Elizabeth Goras, Jacquelyn Kilbourne, Kenneth Lowe, Juliane Daggett-Vondras, Lino Torres, John Christie, Nicole Appel, Anna L. Cox, Jae B. Kim, Grant McFadden
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 171-188 (2020)
Multiple myeloma (MM) is a hematological malignancy of monoclonal plasma cells that remains incurable. Standard treatments for MM include myeloablative regimens and autologous cell transplantation for eligible patients. A major challenge of these tre
Externí odkaz:
https://doaj.org/article/9c0a4c2b6a54423791678350139e6911
Autor:
Thomas Pietschmann, Margarita Zayas, Philip Meuleman, Gang Long, Nicole Appel, George Koutsoudakis, Stephanie Kallis, Geert Leroux-Roels, Volker Lohmann, Ralf Bartenschlager
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6, p e1000475 (2009)
With the advent of subgenomic hepatitis C virus (HCV) replicons, studies of the intracellular steps of the viral replication cycle became possible. These RNAs are capable of self-amplification in cultured human hepatoma cells, but save for the genoty
Externí odkaz:
https://doaj.org/article/03ba2397030748d38deca8c3a37b6166
Autor:
Nicole Appel, Margarita Zayas, Sven Miller, Jacomine Krijnse-Locker, Torsten Schaller, Peter Friebe, Stephanie Kallis, Ulrike Engel, Ralf Bartenschlager
Publikováno v:
PLoS Pathogens, Vol 4, Iss 3, p e1000035 (2008)
Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world population infected with this virus, the lack of a prophylactic
Externí odkaz:
https://doaj.org/article/e4fbe236fc634881a68dd2c20cfcddcf
Autor:
Kenneth M Lowe, Joseph N. Blattman, Masmudur M. Rahman, Jazmin Galvan Achi, Nancy Y. Villa, Lina S. Franco, Ana Lemos de Matos, Hannah Canter, Joshua Carmen, Natalie M. Elliott, Jacquelyn Kilbourne, Nicole Appel, Evelyn Luna, Grant McFadden, John D. Christie
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 22, Iss, Pp 539-554 (2021)
Molecular Therapy: Oncolytics, Vol 22, Iss, Pp 539-554 (2021)
Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination
Autor:
John D. Christie, Nicole Appel, Liqiang Zhang, Kenneth Lowe, Jacquelyn Kilbourne, Juliane Daggett-Vondras, Natalie Elliott, Alexandra R. Lucas, Joseph N. Blattman, Masmudur M. Rahman, Grant McFadden
Publikováno v:
Cancers
Cancers; Volume 14; Issue 2; Pages: 337
Cancers, Vol 14, Iss 337, p 337 (2022)
Cancers; Volume 14; Issue 2; Pages: 337
Cancers, Vol 14, Iss 337, p 337 (2022)
Simple Summary Cancer metastasis to the lung represents the second most common site of metastasis, and a major challenge for clinical treatment of cancer, however, armed oncolytic viruses (Ovs) systemically delivered by carrier leukocytes represents
Publikováno v:
The Journal of Immunology. 208:122.20-122.20
Osteosarcoma is the most common childhood bone malignancy, with a sharp decline in survival rates upon metastasis. We have previously shown immune checkpoint blockade (ICB) of anti-CTLA-4/anti-PD-L1 for mice inoculated with a K7M2 metastatic osteosar
Autor:
Nicole Labban, Joseph N. Blattman, Nicole Appel, Pooja Hingorani, Danielle M. Lussier, Christina K Lettieri
Publikováno v:
Immunotherapy. 8:1233-1244
Survival outcomes for osteosarcoma have plateaued since the 1980s, and patients with relapsed or refractory disease have a particularly dismal outcome. Treatment options for these patients are limited primarily due to the paucity of effective therape
Autor:
Kathleen A. Piotrowski, Grace J. Paik, Nicole Appel, Richard Henker, Nicholas G. Bircher, Susan M. Sereika, Sheila Alexander, Hiroko Henker, Li Meng
Publikováno v:
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses. 34(2)
To evaluate the agreement of temporal artery temperature (Tat) with esophageal temperature (Tes) and oral temperature (Tor), and explore potential factors associated with the level of agreement between the thermometry methods in different clinical se