Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nicole Alessandri-Haber"'
Autor:
Tao Yang, Nicole Alessandri-Haber, Wen Fury, Michael Schaner, Robert Breese, Michael LaCroix-Fralish, Jinrang Kim, Christina Adler, Lynn E. Macdonald, Gurinder S. Atwal, Yu Bai
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Yang et al. present AdRoit, a method for deconvoluting bulk RNA sequencing and spatial transcriptomics data. AdRoit performs well on datasets from complex tissues with many different cell types.
Externí odkaz:
https://doaj.org/article/a3e2519cf434400a89966ed01e1b9379
Autor:
Christina Adler, Macdonald Lynn, Gurinder S. Atwal, Michael Schaner, Jinrang Kim, Tao Yang, Robert Breese, Lacroix-Fralish Michael L, Wen Fury, Yu Bai, Nicole Alessandri-Haber
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Bulk RNA sequencing provides the opportunity to understand biology at the whole transcriptome level without the prohibitive cost of single cell profiling. Advances in spatial transcriptomics enable to dissect tissue organization and function by genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcedf1be98ce40acccb5f5ee4a296dd1
https://doaj.org/article/a3e2519cf434400a89966ed01e1b9379
https://doaj.org/article/a3e2519cf434400a89966ed01e1b9379
Autor:
Nicole Alessandri-Haber, Macdonald Lynn, Yajun Tang, John Mcwhirter, Yu Bai, Daria Zamolodchikov
Publikováno v:
Neuroscience. 413:294-307
Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although typically thought to be restricted to the circulation, FXII protein has been found in the brain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099e0a21040a910f4812152dda51fdd6
https://doi.org/10.1016/j.neuroscience.2019.05.040
https://doi.org/10.1016/j.neuroscience.2019.05.040
Autor:
Christina Adler, Michael Schaner, Nicole Alessandri-Haber, Jinrang Kim, Lacroix-Fralish Michael L, Macdonald Lynn, Robert Breese, Tao Yang, Wen Fury, Gurinder S. Atwal, Yu Bai
RNA sequencing technology promises an unprecedented opportunity in learning disease mechanisms and discovering new treatment targets. Recent spatial transcriptomics methods further enable the transcriptome profiling at spatially resolved spots in a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8aac4f7cfe2d72769382b4f1c66428
https://doi.org/10.1101/2020.12.14.422697
https://doi.org/10.1101/2020.12.14.422697
Autor:
Sachia G. Khasar, David B. Reichling, Paul G. Green, Robert O. Messing, Olayinka A. Dina, Oliver Bogen, Jon D. Levine, Nicole Alessandri-Haber, Xiaojie Chen
Publikováno v:
European Journal of Neuroscience. 28:1180-1190
The neurotoxic effects of catecholamine metabolites have been implicated in neurodegenerative diseases. As some sensory neurons express tyrosine hydroxylase and monoamine oxidase (MAO), we investigated the potential contribution of catecholamine meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc3eccd8eb0a2ea7dd92f9fcb2c518b
https://doi.org/10.1111/j.1460-9568.2008.06425.x
https://doi.org/10.1111/j.1460-9568.2008.06425.x
Stress Induces a Switch of Intracellular Signaling in Sensory Neurons in a Model of Generalized Pain
Autor:
Sachia G. Khasar, Jennifer Burkham, David B. Reichling, Oliver Bogen, Olayinka A. Dina, Jon D. Levine, Paul G. Green, Adrienne S. Brown, Nicole Alessandri-Haber
Publikováno v:
The Journal of Neuroscience. 28:5721-5730
Stress dramatically exacerbates pain in diseases such as fibromyalgia and rheumatoid arthritis, but the underlying mechanisms are unknown. We tested the hypothesis that stress causes generalized hyperalgesia by enhancing pronociceptive effects of imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc4a8536d6503d8985b3a5e8e20a784
https://doi.org/10.1523/jneurosci.0256-08.2008
https://doi.org/10.1523/jneurosci.0256-08.2008
Autor:
Sachia G. Khasar, Jon D. Levine, Olayinka A. Dina, Robert O. Messing, Paul G. Green, Nicole Alessandri-Haber
Publikováno v:
European Journal of Neuroscience. 27:83-92
Chronic alcohol consumption induces a painful small-fiber peripheral neuropathy, the severity of which increases during alcohol withdrawal. Chronic alcohol consumption also produces a sustained increase in stress hormones, epinephrine and corticoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942fd5d44f533390ca1c7e7e70ca9b4d
https://doi.org/10.1111/j.1460-9568.2007.05987.x
https://doi.org/10.1111/j.1460-9568.2007.05987.x
Publikováno v:
Pain. 132:67-73
While protein kinase C epsilon has been shown to contribute to acute and chronic mechanical hyperalgesia, its upstream signaling pathway has received little attention. Since phospholipase C can signal to PKC epsilon and has been implicated in nocicep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc583d5900e572c2a3d95d12cc0de06
https://doi.org/10.1016/j.pain.2007.01.027
https://doi.org/10.1016/j.pain.2007.01.027
Autor:
Olayinka A. Dina, Elizabeth K. Joseph, David B. Reichling, Nicole Alessandri-Haber, Jon D. Levine
Publikováno v:
The Journal of Neuroscience. 26:3864-3874
The transient receptor potential vanilloid 4 (TRPV4) is a primary afferent transducer that plays a crucial role in neuropathic hyperalgesia for osmotic and mechanical stimuli, as well as in inflammatory mediator-induced hyperalgesia for osmotic stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad37e96b942205e2e54fdc05ebc9749
https://doi.org/10.1523/jneurosci.5385-05.2006
https://doi.org/10.1523/jneurosci.5385-05.2006
Autor:
Olayinka A. Dina, Carlos Amílcar Parada, Nicole Alessandri-Haber, Jon D. Levine, David B. Reichling, Jenny J. Yeh
Publikováno v:
The Journal of Neuroscience. 24:4444-4452
The development of treatments for neuropathic pain has been hindered by our limited understanding of the basic mechanisms underlying abnormalities in nociceptor hyperexcitability. We recently showed that the polymodal receptor transient receptor pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a599c74923bcc3ada5a50dad98cdbe48
https://doi.org/10.1523/jneurosci.0242-04.2004
https://doi.org/10.1523/jneurosci.0242-04.2004