Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicole A. Spiegelman"'
Autor:
Miao Wang, Yugang Zhang, Garrison P. Komaniecki, Xuan Lu, Ji Cao, Mingming Zhang, Tao Yu, Dan Hou, Nicole A. Spiegelman, Ming Yang, Ian R. Price, Hening Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here the authors revealed a role for the protein deacetylase SIRT2 in Golgi stress, particularly induced by bacterial infection. Shigella secrete effector proteins such as IcsB, which transfers fatty acyl groups to modify host proteins to evade host
Externí odkaz:
https://doaj.org/article/d661b6c536494c51b3b9c8d2562bb169
Autor:
Hui Jing, Xiaoyu Zhang, Stephanie A Wisner, Xiao Chen, Nicole A Spiegelman, Maurine E Linder, Hening Lin
Publikováno v:
eLife, Vol 6 (2017)
Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and identifying new targets for treatin
Externí odkaz:
https://doaj.org/article/a314c067e5cd4722ac95d98f23e7767a
Publikováno v:
eLife, Vol 6 (2017)
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases. Here, we report that a novel posttranslational mechanism, reve
Externí odkaz:
https://doaj.org/article/9cb0301a35a7472f8213fc0ba824e33a
Autor:
Ian R. Price, Min Yang, Jun Young Hong, Nicole A Spiegelman, Hui Jing, Xiaoyu Zhang, Ji Cao, Hening Lin, Jing Hu, Miao Wang
Publikováno v:
ChemMedChem. 14:744-748
SIRT2, a member of the sirtuin family of protein lysine deacylases, has been identified as a promising therapeutic target for treating cancer. In addition to catalyzing deacetylation, SIRT2 has recently been shown to remove fatty acyl groups from K-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848405bfb42f230107cc9cf5f3304f17
https://doi.org/10.1002/cmdc.201800715
https://doi.org/10.1002/cmdc.201800715
Autor:
Pornpun Aramsangtienchai, Xiaoyu Zhang, Nicole A Spiegelman, Ji Cao, Hening Lin, Weishan Huang, Lei Sun, Edward Seto
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance HDAC11 is the only class IV member of the histone deacetylase (HDAC) family, and very little is known about its biological function. The work here reveals its efficient and physiologically relevant activity. The regulation of SHMT2 and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dd05658796d3707254b2ca4de68f59
http://europepmc.org/articles/PMC6431144
http://europepmc.org/articles/PMC6431144
Autor:
Miao Wang, Yugang Zhang, Garrison P. Komaniecki, Xuan Lu, Ji Cao, Mingming Zhang, Tao Yu, Dan Hou, Nicole A. Spiegelman, Ming Yang, Ian R. Price, Hening Lin
Publikováno v:
Nature communications. 13(1)
Enzymes from pathogens often modulate host protein post-translational modifications (PTMs), facilitating survival and proliferation of pathogens. Shigella virulence factors IpaJ and IcsB induce proteolytic cleavage and lysine fatty acylation on host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad926d5ddc28c03b00a25a61cb98f34
https://pubmed.ncbi.nlm.nih.gov/35918380
https://pubmed.ncbi.nlm.nih.gov/35918380
Autor:
Ilana B Kotliar, Zhen Tong, Ji Cao, Xiaoyu Zhang, Hening Lin, Hui Jing, Kelly M Rosch, Miao Wang, Pornpun Aramsangtienchai, Nicole A Spiegelman
Publikováno v:
ACS Chem Biol
Protein lysine fatty acylation is increasingly recognized as a prevalent and important protein post-translation modification. Recently, it has been shown that K-Ras4a, R-Ras2, and Rac1 are regulated by lysine fatty acylation. Here we investigated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66847ce0eab695d996ef2c7776961d76
https://pubmed.ncbi.nlm.nih.gov/31433161
https://pubmed.ncbi.nlm.nih.gov/31433161
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995318
Protein fatty-acylation is an important post-translational modification (PTM) and has been associated with many fundamental biological processes. Sirtuins, the nicotinamide adenine dinucleotide (NAD) dependent class of histone deacetylases have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d834aa72423038986108bd1f65f76530
https://pubmed.ncbi.nlm.nih.gov/31152401
https://pubmed.ncbi.nlm.nih.gov/31152401
Autor:
Pornpun Aramsangtienchai, Ji Cao, Ian R. Price, Hening Lin, Sushabhan Sadhukhan, Hui Jing, Jun Young Hong, Xiaoyu Zhang, Nicole A Spiegelman, Miao Wang, Min Yang
Publikováno v:
ChemMedChem. 13(18)
Sirtuin inhibitors have attracted much interest due to the involvement of sirtuins in various biological processes. Several SIRT2-selective inhibitors have been developed, and some exhibit anticancer activities. To facilitate the choice of inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f70d1e844f6ba8f2d46b05030f31e1c
https://pubmed.ncbi.nlm.nih.gov/30058233
https://pubmed.ncbi.nlm.nih.gov/30058233
