Výsledky vyhledávání - "Nicole A. Kennedy"

Akademický článek

Identification of potent small molecule inhibitors of SARS-CoV-2 entry

Publikováno v: SLAS Discovery, Vol 27, Iss 1, Pp 8-19 (2022)

The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a persistent threat to mankind, especially for the immunocompromised and elderly for which the vaccine may have limited effectiveness. Entry of SARS-CoV-2 requires a

Externí odkaz: https://doaj.org/article/2347b83126774a29aab28c5d045a7718

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Akademický článek

Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Autor: Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn

Publikováno v: Biomolecules, Vol 13, Iss 6, p 935 (2023)

Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTP�

Externí odkaz: https://doaj.org/article/14dc2c96072240f297e8663c127868ee

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Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Autor: Bohn, Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M.

Publikováno v: Biomolecules; Volume 13; Issue 6; Pages: 935

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::59eab5949a2ddf76129f1acc76791544

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Hyperactivity in mice induced by opioid agonists with partial intrinsic efficacy and biased agonism; alone and in combination with morphine

Autor: Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn

Opioid analgesics like morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Here we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using35S-GTPγS bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b6cf1fcc18e70e22d87dc30cc884931
https://doi.org/10.1101/2023.05.11.540403

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G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists

Autor: Nicole M. Kennedy, Cullen L. Schmid, Agnes Acevedo-Canabal, Edward L. Stahl, Laura M. Bohn, Cai Read, Travis W. Grim, Thomas D. Bannister

Publikováno v: Proc Natl Acad Sci U S A

The ability of a ligand to preferentially promote engagement of one signaling pathway over another downstream of GPCR activation has been referred to as signaling bias, functional selectivity, and biased agonism. The presentation of ligand bias refle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c3fb22b788a2b9c93de2a22ba74551
https://doi.org/10.1073/pnas.2102178118

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A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

Autor: Nicole M. Kennedy, Michael D. Cameron, Cullen L. Schmid, Laura M. Bohn, Edward L. Stahl, Jo-Hao Ho, Fani Pantouli, Travis W. Grim, Thomas D. Bannister, Agnes Acevedo-Canabal

Publikováno v: Neuropsychopharmacology

It has been demonstrated that opioid agonists that preferentially act at μ-opioid receptors to activate G protein signaling over βarrestin2 recruitment produce antinociception with less respiratory suppression. However, most of the adverse effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ba507bd11f0a076c1bf54d1049ade0
https://doi.org/10.1038/s41386-019-0491-8

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Emerging investigator series: transformation of common antibiotics during water disinfection with chlorine and formation of antibacterially active products

Autor: Olya S. Keen, Nicole L. Kennedy Neth, Clifford M. Carlin

Publikováno v: Environmental Science: Water Research & Technology. 5:1222-1233

This study investigated the effect of chlorine disinfection on the following commonly prescribed antibiotics typically present in treated wastewater: ciprofloxacin, trimethoprim, sulfamethoxazole, levofloxacin and ofloxacin. Antibacterially active tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2213b9e073517146087f6e695781bea8
https://doi.org/10.1039/c9ew00182d

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