Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicole A. J. Krentz"'
Autor:
Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua, Marta Perez-Alcantara, Jun-Wei Chan, Jila Ajeian, Soumita Ghosh, Yunkyeong Lee, Jing Yang, Swaraj Thaman, Benoite Champon, Han Sun, Alokkumar Jha, Shawn Hoon, Nguan Soon Tan, Daphne Su-Lyn Gardner, Shih Ling Kao, E. Shyong Tai, Anna L. Gloyn, Adrian Kee Keong Teo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its role on human beta cell deve
Externí odkaz:
https://doaj.org/article/04c9903c45a041a292092f38195e3bde
Autor:
Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F. Spigelman, Han Sun, Jennifer M. Ikle, Swaraj Thaman, Antje K. Rottner, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E. Manning Fox, Jason M. Torres, Agata Wesolowska-Andersen, Grace Z. Yu, Anubha Mahajan, Anders Larsson, Patrick E. MacDonald, Benjamin Davies, Marcel den Hoed, Anna L. Gloyn
Publikováno v:
Diabetologia. 66:674-694
Aims/hypothesis Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. However, little is known about the function of the zinc finger transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fa56621fef9812409ed7ea80259057
https://doi.org/10.1007/s00125-022-05856-6
https://doi.org/10.1007/s00125-022-05856-6
Autor:
Tamadher A. Alghamdi, Nicole A. J. Krentz, Nancy Smith, Aliya F. Spigelman, Varsha Rajesh, Alok Jha, Mourad Ferdaoussi, Jocelyn E Manning Fox, Han Sun, Zijie Sun, Anna L. Gloyn, Patrick E. MacDonald
Genome-wide association studies have identified hundreds of signals for type 2 diabetes (T2D), most of which confer risk through effects on gene expression. We previously identified the transcription factor ZMIZ1 as a probable effector transcript in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295d231f94f5a18823e340251aa8e8d8
https://doi.org/10.1101/2022.05.18.492530
https://doi.org/10.1101/2022.05.18.492530
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114275 (2014)
Human embryonic stem cells (hESCs) have great promise as a source of unlimited transplantable cells for regenerative medicine. However, current progress on producing the desired cell type for disease treatment has been limited due to an insufficient
Externí odkaz:
https://doaj.org/article/30a2b041445b4b4c9b6203ca13624387
Autor:
Nicole A J, Krentz, Anna L, Gloyn
Publikováno v:
Nature reviews. Endocrinology. 16(4)
Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has both genetic and environmental risk factors, resulting in impaired glucose homeostasis. Genome-wide association studies (GWAS) have identified over 400 genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5af6927718b84f87964f34b851ae99d
https://pubmed.ncbi.nlm.nih.gov/32099086
https://pubmed.ncbi.nlm.nih.gov/32099086
Autor:
Francis C. Lynn, Nicole A. J. Krentz
Publikováno v:
Genome Editing ISBN: 9783319341460
Human pluripotent stem cells (hPSCs) have the ability to form all cell types of the body, making them an excellent potential source of insulin-producing pancreatic β-cells for diabetes treatment. To generate these cells in vitro requires a complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::698a5a102a2c6f08f10c95029e93595e
https://doi.org/10.1007/978-3-319-34148-4_8
https://doi.org/10.1007/978-3-319-34148-4_8