Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicole A. Chartrain"'
Autor:
Susan Cupo, John S. Mudgett, Nicole A. Chartrain, Karen Lowitz, Catherine E. Fitzgerald, Dennis M. Zaller, Ester Carballo-Jane, Stephen J. O'Keefe, Silvi Luell, Cordelia Rasa, Karen Owens, Shiow-Ling Chen, Denise M. Visco, Janey N. Parsons
Publikováno v:
Journal of Biological Chemistry. 282:34663-34671
The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation. Defining the roles of the various p38 family members, specifically p38alpha and p38beta, in these processes has been dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdd43cddde72b5f75a9b11bba35774d
https://doi.org/10.1074/jbc.m704236200
https://doi.org/10.1074/jbc.m704236200
Autor:
Nicole A. Chartrain, Lucia Guh-Siesel, Jixiang Ding, Lu Yang, Michael M. Shen, Shobhna Gopal, John S. Mudgett
Publikováno v:
Proceedings of the National Academy of Sciences. 97:10454-10459
The p38 family of mitogen-activated protein kinases (MAPKs) mediates signaling in response to environmental stresses and inflammatory cytokines, but the requirements for the p38 MAPK pathway in normal mammalian development have not been elucidated. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf19d352ce6ed58822eb6b83c1fd40cb
https://doi.org/10.1073/pnas.180316397
https://doi.org/10.1073/pnas.180316397
Autor:
Irwin I. Singer, John G. Flanagan, Nicole A. Chartrain, A. J. Forsyth, Howard Y. Chen, C. F. Shen, Ellen K. Bayne, Denise M. Visco, John S. Mudgett, Karla Stevens, Myrna E. Trumbauer, Douglas W. Kawka, Nancy I. Hutchinson, Joseph McDonnell
Publikováno v:
Arthritis & Rheumatism. 41:110-121
Objective It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40bc945bd67c1f43055f07ca05f542da
https://doi.org/10.1002/1529-0131(199801)41:1<110::aid-art14>3.0.co
https://doi.org/10.1002/1529-0131(199801)41:1<110::aid-art14>3.0.co
Autor:
Myrna E. Trumbauer, Daniel S. Fletcher, Karen Sokol, Qiao-wen Xie, Gary J Hom, Carl Nathan, Karla Stevens, John D. MacMicking, Nicole A. Chartrain, John S. Mudget, Nancy I. Hutchinson, Howard Y. Chen
Publikováno v:
Cell. 81(4):641-650
Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that !NOS defends the host against infectious agents and tumor cells at the risk of contributing to tissue damage and shock. iNOS -I- mice failed to restrain the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025e4451ecbec3e1d402f3b0a30c1b63
Autor:
John S. Mudgett, N F Sitrin, Nancy I. Hutchinson, Patrick P. Koty, Nicole A. Chartrain, Eric P. Hoffman, Andreas K. Nussler, T R Billiar, David A. Geller
Publikováno v:
Journal of Biological Chemistry. 269:6765-6772
Nitric oxide, a multifunctional effector molecule synthesized by nitric oxide synthase (NOS) from L-arginine, conveys signals for vasorelaxation, neurotransmission, and cytotoxicity. Three different NOS isoforms have been identified which fall into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1423683d0d23247a70c01a353d63e0be
https://doi.org/10.1016/s0021-9258(17)37441-0
https://doi.org/10.1016/s0021-9258(17)37441-0
Autor:
Nancy I. Hutchinson, Michael J. Tocci, Karen L. MacNaul, Nicole A. Chartrain, Michael W. Lark
Publikováno v:
Journal of Biological Chemistry. 265:17238-17245
Primary and passaged human synovial fibroblasts isolated from rheumatoid pannus were treated with recombinant interleukin-1 (IL-1) alpha or beta, tumor necrosis factor-alpha (TNF), or phorbol myristate acetate (PMA) to determine the effects of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a92f65188950014093a170334529551
https://doi.org/10.1016/s0021-9258(17)44894-0
https://doi.org/10.1016/s0021-9258(17)44894-0
Publikováno v:
Gene. 87(2)
Protoplast fusion is a method for directly transferring cloned DNA from bacteria to mammalian cells at high efficiency. Here, we have used membrane-bound alkaline phosphatase as a reporter enzyme in a miniprotoplast fusion assay. This work demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430761e805825463231ddbee3f7984f5
https://pubmed.ncbi.nlm.nih.gov/2332173
https://pubmed.ncbi.nlm.nih.gov/2332173
Autor:
Guadalupe A. Limjuco, Jayne Chin, Patricia M. Cameron, Nicole A. Chartrain, John A. Schmidt, Matthew J. Kostura, Andrew G. Hillman, Michael J. Tocci
Publikováno v:
Proceedings of the National Academy of Sciences. 86:5227-5231
Interleukin 1 (IL-1) is a lymphokine secreted by monocytes in response to a variety of inflammatory stimuli. IL-1 beta, the predominant form of IL-1 produced by human monocytes, is synthesized as an inactive precursor of 31 kDa and is cleaved at Asp1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96c6708d82c8310b7c29b51ef1a0c7a
https://doi.org/10.1073/pnas.86.14.5227
https://doi.org/10.1073/pnas.86.14.5227