Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nicole A Mortier"'
Autor:
Vivien A Sheehan, Jacy R Crosby, Aniko Sabo, Nicole A Mortier, Thad A Howard, Donna M Muzny, Shannon Dugan-Perez, Banu Aygun, Kerri A Nottage, Eric Boerwinkle, Richard A Gibbs, Russell E Ware, Jonathan M Flanagan
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110740 (2014)
Hydroxyurea has proven efficacy in children and adults with sickle cell anemia (SCA), but with considerable inter-individual variability in the amount of fetal hemoglobin (HbF) produced. Sibling and twin studies indicate that some of that drug respon
Externí odkaz:
https://doaj.org/article/92b9698c6a9b4d21be5ddfd8aef760dd
Autor:
Jasmine Baker, Jonathan M. Flanagan, Thomas N. Williams, Brigida Santos, George Tomlinson, Russell E. Ware, Rosa M. Nieves, Adam Lane, Kathryn L McElhinney, Teresa Latham, Susan E. Stuber, Peter Olupot-Olupot, Anu Marahatta, Nicole A. Mortier, William H. Schultz, Angela Rankine-Mullings, Thad A. Howard, Patrick T. McGann, Marvin Reid, Rafael Mena, Banu Aygun, Robert O. Opoka, Léon Tshilolo, Chandy C. John
Publikováno v:
Blood. 136:8-9
Introduction: Hydroxyurea is a potent therapeutic agent for sickle cell anemia (SCA), and treatment at maximum tolerated dose (MTD) is becoming the standard of care. Hydroxyurea exerts its disease-modifying effects primarily through induction of feta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ef820756a52e8cdc64420f3169d7d8a
https://doi.org/10.1182/blood-2020-143139
https://doi.org/10.1182/blood-2020-143139
Autor:
Janet L. Kwiatkowski, Lori Luchtman-Jones, Linda B. Piller, Jennifer A. Rothman, Abdullah Kutlar, R. Clark Brown, Theodosia A. Kalfa, Carla W. Roberts, William H. Schultz, Nicole A. Mortier, Robert J. Adams, Alexis A. Thompson, William Owen, Beng Fuh, Margaret T. Lee, Jamie L. Coleman, Judy Luden, Alex George, Donna R. Roberts, John C. Wood, Kerri Nottage, Ofelia A. Alvarez, Sharada A. Sarnaik, Melanie J. Bonner, Susan E. Stuber, Lee Hilliard, Hamayun Imran, Stephen C. Nelson, Sherron M. Jackson, Sara L. Pressel, Banu Aygun, Matthew M. Heeney, Melissa Rhodes, Connie M. Piccone, Naomi L.C. Luban, Zora R. Rogers, Scott T. Miller, Peng Wei, Kathleen J. Helton, Cynthia Gauger, Isaac Odame, Barry R. Davis, Russell E. Ware, Alan R. Cohen, Niren Patel
Publikováno v:
Lancet (London, England)
Summary Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxycarbamide (hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c7e5d79309566d8761ac8cd85c3945
https://doi.org/10.1016/s0140-6736(15)01041-7
https://doi.org/10.1016/s0140-6736(15)01041-7
Autor:
Russell E. Ware, Pamela B. Sylvestre, Scott T. Miller, Karen Kesler, Zora R. Rogers, Peter A. Lane, Janet L. Kwiatkowski, William H. Schultz, Banu Aygun, Nicole A. Mortier, Alan R. Cohen, Alexandre Lockhart, Rathi V. Iyer, Ofelia A. Alvarez
Publikováno v:
British Journal of Haematology. 169:262-266
Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3605d1074a072ae2bd3029430718131b
https://doi.org/10.1111/bjh.13280
https://doi.org/10.1111/bjh.13280
Autor:
Banu Aygun, Jane S. Hankins, Russell E. Ware, Nicole A. Mortier, Geoffrey Neale, Amy C. Kimble, Shirley A. Steward, Jonathan M. Flanagan, Thad A. Howard
Publikováno v:
British Journal of Haematology. 157:240-248
Sickle cell anaemia (SCA) is a severe debilitating haematological disorder associated with a high degree of morbidity and mortality. The level of fetal haemoglobin (HbF) is well-recognized as a critical laboratory parameter: lower HbF is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d419328fe284db136c5466679eb484f3
https://doi.org/10.1111/j.1365-2141.2012.09061.x
https://doi.org/10.1111/j.1365-2141.2012.09061.x
Autor:
Ronald W. Helms, Rathi V. Iyer, Zora R. Rogers, Scott T. Miller, Russell E. Ware, Nicole A. Mortier, Myron A. Waclawiw, Lee Hilliard, William H. Schultz, Nancy A. Yovetich, J. Paul Scott, Ofelia A. Alvarez
Publikováno v:
Pediatric Blood & Cancer. 57:1011-1017
Background Stroke occurs in 5–10% of children with sickle cell anemia (SCA) and has a high (>50%) risk of recurrence without therapy. Chronic monthly erythrocyte transfusions effectively prevent recurrent stroke, but their long term use is limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182278130d86d1c77d2dadc715e12687
https://doi.org/10.1002/pbc.23145
https://doi.org/10.1002/pbc.23145
Publikováno v:
Blood. 110:1043-1047
Hydroxyurea has hematologic and clinical efficacy in sickle cell anemia (SCA), but its effects on transcranial Doppler (TCD) flow velocities remain undefined. Fifty-nine children initiating hydroxyurea therapy for clinical severity had pretreatment b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc22f2b385568500f05efca5cb3daf6e
https://doi.org/10.1182/blood-2006-11-057893
https://doi.org/10.1182/blood-2006-11-057893
Autor:
William H. Schultz, Russell E. Ware, Jacqueline S. Davis, Nicole A. Mortier, Pamela B. Sylvestre, Sherri A. Zimmerman, William R. Treem
Publikováno v:
The Journal of Pediatrics. 145:346-352
Objective Transfusions prevent secondary stroke in children with sickle cell anemia (SCA) but also cause iron overload. Alternatives for stroke prophylaxis with effective therapy to reduce iron burden are needed. Study design For 35 children with SCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0973c8fcc29669cfccef240a50b4793a
https://doi.org/10.1016/j.jpeds.2004.04.058
https://doi.org/10.1016/j.jpeds.2004.04.058
Autor:
Alan R. Cohen, Janet L. Kwiatkowski, Sharada A. Sarnaik, William H. Schultz, Russell E. Ware, Ramamorrthy Nagasubramanian, Nicole A. Mortier, Julian Garro, Alexis A. Thompson, Peter A. Lane, Brigitta U. Mueller, Nancy A. Yovetich, Ofelia A. Alvarez, Gerald M. Woods
Publikováno v:
American Journal of Hematology. 87:221-223
Chronic transfusion reduces the risk of recurrent stroke in children with sickle cell anemia (SCA) but leads to iron loading. Management of transfusional iron overload in SCA has been reported as suboptimal [1], but studies characterizing monitoring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b9f461aac328dff5d78cc6bdc0c97
https://doi.org/10.1002/ajh.22228
https://doi.org/10.1002/ajh.22228
Publikováno v:
Pediatric Blood & Cancer. 56:837-839
Autoimmune hemolytic anemia (AIHA) is characterized by the presence of autoantibodies, most frequently of the IgG isotype, directed against erythrocyte surface antigens. The direct antiglobulin test (DAT) is the critical laboratory test for the diagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::240eb60b3444f78921a6adf215f5b950
https://doi.org/10.1002/pbc.22932
https://doi.org/10.1002/pbc.22932