Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicole A Bakas"'
Autor:
Allison S. Limpert, Lena M. Berger, Stefan Knapp, Lester J. Lambert, Nicholas D. P. Cosford, Fabiana I.A.L. Layng, Apirat Chaikuad, Cunxiang Yuan, Jing Dong, Li Wang, Maria Celeridad, Yi Peng, Douglas J. Sheffler, Nicole Bata, Guoxiong Liu, Nicole A Bakas
Publikováno v:
J Med Chem
Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key components of the Hippo signaling pathway, which regulates cell proliferation and death and provides a potential therapeutic target for acute myeloid leukemia (AML). Herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc05bd607eb905af295851148fa0764
https://europepmc.org/articles/PMC10149138/
https://europepmc.org/articles/PMC10149138/
Autor:
Nicole A Bakas, Lester J. Lambert, Nicholas D. P. Cosford, Mitchell Vamos, Huiyu Ren, Apirat Chaikuad, Reuben J. Shaw, Carina Wimer, Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Sonja N. Brun, Allison S. Limpert, Stefan Knapp
Publikováno v:
J Med Chem
Inhibition of autophagy, the major cellular recycling pathway in mammalian cells, is a promising strategy for the treatment of triple-negative breast cancer (TNBC). We previously reported SBI-0206965, a small molecule inhibitor of unc-51-like autopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e4b2f1d43e7a3f43e170153e08bf32
https://europepmc.org/articles/PMC8064294/
https://europepmc.org/articles/PMC8064294/
Publikováno v:
Anticancer research. 38(10)
Proteasome inhibition is a validated therapeutic strategy for the treatment of refractory and relapsed multiple myeloma (MM) and mantle cell lymphoma. We previously showed that thiasyrbactins (NAM compounds) are inhibitors with an affinity for the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80071186f2d14d43d0463d827a563489
https://pubmed.ncbi.nlm.nih.gov/30275178
https://pubmed.ncbi.nlm.nih.gov/30275178
Autor:
Michael C. Pirrung, Nicole A. Bakas
Publikováno v:
Pirrung, MC; & Bakas, NA. (2018). Homoserine and Threonine Peptide Assembly. SYNLETT, 29(2), 238-242. doi: 10.1055/s-0036-1589123. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/94m8n58z
Drawing on our recent success with reagent-less peptide-bond formation through serine-based assembly reactions in organic solvent, their range has been expanded to threonine and homoserine (an aspartic acid precursor) in the N-terminal peptide. Amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e114e63936e03c68e18f2f6cba66b520
http://www.escholarship.org/uc/item/94m8n58z
http://www.escholarship.org/uc/item/94m8n58z
Autor:
André S. Bachmann, Christopher C. Roberts, Lisette P. Yco, Nicole A. Bakas, Chia-en A. Chang, Michael C. Pirrung, Chad R. Schultz
Publikováno v:
Bioorganicmedicinal chemistry. 26(2)
A family of macrodilactam natural products, the syrbactins, are known proteasome inhibitors. A small group of syrbactin analogs was prepared with a sulfur-for-carbon substitution to enhance synthetic accessibility and facilitate modulation of their s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea243a8e64dc5b3fe8bcdca3d9b8a021
https://pubmed.ncbi.nlm.nih.gov/29269255
https://pubmed.ncbi.nlm.nih.gov/29269255