Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Nicole A, Horenstein"'
Autor:
Hailey E. Beal, Nicole A. Horenstein
Publikováno v:
AMB Express, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Azasugars are monosaccharide analogs in which the ring oxygen is replaced with a nitrogen atom. These well-known glycosidase inhibitors are of interest as therapeutics, yet several aspects of azasugars remain unknown including their distribu
Externí odkaz:
https://doaj.org/article/96af2cf71d2d4bd080d0e651c05a68a6
Autor:
Katrin Richter, Roger L. Papke, Clare Stokes, Danika C. Roy, Eduardo S. Espinosa, Philipp M. K. Wolf, Andreas Hecker, Juliane Liese, Vijay K. Singh, Winfried Padberg, Klaus-Dieter Schlüter, Marius Rohde, J. Michael McIntosh, Barbara J. Morley, Nicole A. Horenstein, Veronika Grau, Alain R. Simard
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate inflammation but have little or no ionotropic activity, are of outstanding
Externí odkaz:
https://doaj.org/article/1f0c695d5b094b88ab15c35a1caca9c0
Publikováno v:
Molecules, Vol 26, Iss 18, p 5643 (2021)
The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor
Externí odkaz:
https://doaj.org/article/840b1cbdcc7540c3a3df8e05a6ffb8ca
Autor:
Clare Stokes, Jose A. Pino, D. Walker Hagan, Gonzalo E. Torres, Edward A. Phelps, Nicole A. Horenstein, Roger L. Papke
Publikováno v:
Addiction Biology. 27
The use of areca nuts (areca) in the form of betel quids constitutes the fourth most common addiction in the world, associated with high risk for oral disease and cancer. Areca is a complex natural product, making it difficult to identify specific co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f337902be44ca6e0a3459615a38e4dd1
https://doi.org/10.1111/adb.13223
https://doi.org/10.1111/adb.13223
Autor:
Sumanta Garai, Roger L. Papke, Clare Stokes, Khalil A. Abboud, Nicole A. Horenstein, Arthur D. Zimmerman, Ganesh A. Thakur
Publikováno v:
Molecular Pharmacology. 98:292-302
Many synthetic compounds to which we attribute specific activities are produced as racemic mixtures of stereoisomers, and it may be that all the desired activity comes from a single enantiomer. We have previously shown this to be the case with the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917339f3dcf82aad421d14745ea756ad
https://doi.org/10.1124/mol.120.119958
https://doi.org/10.1124/mol.120.119958
Publikováno v:
Mini Rev Med Chem
The α7 nicotinic acetylcholine receptor is a homopentameric ion-channel of the Cys-loop superfamily characterized by its low probability of opening, high calcium permeability, and rapid desensitization. The α7 receptor has been targeted for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8eaecf63af59c00c5b8f59101a7566b
https://doi.org/10.2174/1389557520666200130105256
https://doi.org/10.2174/1389557520666200130105256
Autor:
Nicole A. Horenstein, Claribel Nuñez
Publikováno v:
Journal of Natural Products. 82:3401-3409
Azasugars, "nitrogen in the ring" analogues of monosaccharides, are known to be distributed in select plant, fungal. and bacterial species. We identify Chitinophaga pinensis DSM 2588 as the first bacterial source of the plant pyrrolidine azasugar 1,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b0ce13ab1503a66788a91fe1dc968b
https://doi.org/10.1021/acs.jnatprod.9b00758
https://doi.org/10.1021/acs.jnatprod.9b00758
Autor:
Roger L. Papke, M. Imad Damaj, Jean-Rémi Godin, Marta Quadri, Ramya Narendrula-Kotha, Deniz Bagdas, Nicole A. Horenstein, Wisam Toma, Patrick Roy, Osama A. Kishta, Alain R. Simard
Publikováno v:
Brain, behavior, and immunity
Nicotinic acetylcholine receptors (nAChRs) are best known to function as ligand-gated ion channels in the nervous system. However, recent evidence suggests that nicotine modulates inflammation by desensitizing non-neuronal nAChRs, rather than by indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e643c315115f010078720be08fa53906
http://europepmc.org/articles/PMC7604877
http://europepmc.org/articles/PMC7604877
Autor:
Joseph Zimmerman, Rosa Mirabel, Nikhil M. Urs, Ion Ghiviriga, Nicole A. Horenstein, Darian K. Phidd, Haoxi Li
Dopamine regulates normal functions such as movement, reinforcement learning, and cognition, and its dysfunction has been implicated in multiple psychiatric and neurological disorders. Dopamine acts through the D1- (D1R and D5R) and D2-class (D2R, D3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42897f057ab608ee622c894124b2684
https://doi.org/10.1101/2021.10.01.462758
https://doi.org/10.1101/2021.10.01.462758
Autor:
Katrin, Richter, Roger L, Papke, Clare, Stokes, Danika C, Roy, Eduardo S, Espinosa, Philipp M K, Wolf, Andreas, Hecker, Juliane, Liese, Vijay K, Singh, Winfried, Padberg, Klaus-Dieter, Schlüter, Marius, Rohde, J Michael, McIntosh, Barbara J, Morley, Nicole A, Horenstein, Veronika, Grau, Alain R, Simard
Publikováno v:
Frontiers in cellular neuroscience. 16
Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate inflammation but have little or no ionotropic activity, are of outstanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f215eb77c52589da4049789d231d1ef
https://pubmed.ncbi.nlm.nih.gov/35431807
https://pubmed.ncbi.nlm.nih.gov/35431807