Zobrazeno 1 - 10 of 250 pro vyhledávání: '"Nicole Urban"'
1
Akademický článek
The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet–Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids
Autor: Marco Keller, Karl Sauvageot-Witzku, Franz Geisslinger, Nicole Urban, Michael Schaefer, Karin Bartel, Franz Bracher
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2716-2725 (2021)
We present a systematic investigation on an improved variant of the N-acyl-Pictet–Spengler condensation for the synthesis of 1-benzyltetrahydroisoquinolines, based on our recently published synthesis of N-methylcoclaurine, exemplified by the total
Externí odkaz: https://doaj.org/article/a76b04de38f9421cb40943bfd05022a1
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2
Akademický článek
Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass
Autor: Matthew F. Buas, Charles W. Drescher, Nicole Urban, Christopher I. Li, Lisa Bettcher, Nitai C. Hait, Kirsten B. Moysich, Kunle Odunsi, Daniel Raftery, Li Yan
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Altered lipid metabolism has emerged as an important feature of ovarian cancer (OC), yet the translational potential of lipid metabolites to aid in diagnosis and triage remains unproven. We conducted a multi-level interrogation of lipid meta
Externí odkaz: https://doaj.org/article/c1a47bab9ef84f9d943aba69efb9e0d4
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3
Akademický článek
Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors
Autor: Philipp Rühl, Anna Scotto Rosato, Nicole Urban, Susanne Gerndt, Rachel Tang, Carla Abrahamian, Charlotte Leser, Jiansong Sheng, Archana Jha, Günter Vollmer, Michael Schaefer, Franz Bracher, Christian Grimm
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal storage disease, while temporary inhibition of this ion channel has been proposed to b
Externí odkaz: https://doaj.org/article/4ae8395bdd4d48a1b970609d440ac4a3
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4
Akademický článek
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
Autor: Susanne Gerndt, Cheng-Chang Chen, Yu-Kai Chao, Yu Yuan, Sandra Burgstaller, Anna Scotto Rosato, Einar Krogsaeter, Nicole Urban, Katharina Jacob, Ong Nam Phuong Nguyen, Meghan T Miller, Marco Keller, Angelika M Vollmar, Thomas Gudermann, Susanna Zierler, Johann Schredelseker, Michael Schaefer, Martin Biel, Roland Malli, Christian Wahl-Schott, Franz Bracher, Sandip Patel, Christian Grimm
Publikováno v: eLife, Vol 9 (2020)
Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et
Externí odkaz: https://doaj.org/article/64c41b16eef7442a8eaf94088d92df5d
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