Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Nicole, Pfarr"'
Autor:
Sebastian Foersch, Maxime Schmitt, Anne‐Sophie Litmeyer, Markus Tschurtschenthaler, Thomas Gress, Detlef K Bartsch, Nicole Pfarr, Katja Steiger, Carsten Denkert, Moritz Jesinghaus
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 5, Pp n/a-n/a (2024)
Abstract Antibody–drug conjugates (ADCs) directed to trophoblast cell surface antigen 2 (TROP2) have gained approval as a therapeutic option for advanced triple‐negative breast cancer, and TROP2 expression has been linked to unfavourable outcomes
Externí odkaz:
https://doaj.org/article/8a36804c34c64ace9a0a2bc6238a569b
Autor:
Leonhard Stark, Atsuko Kasajima, Fabian Stögbauer, Benedikt Schmidl, Jakob Rinecker, Katharina Holzmann, Sarah Färber, Nicole Pfarr, Katja Steiger, Barbara Wollenberg, Jürgen Ruland, Christof Winter, Markus Wirth
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most common histologic subtype,
Externí odkaz:
https://doaj.org/article/3924f13f9d754236b920773600a561fe
Autor:
Olaf Neumann, Ulrich Lehmann, Stephan Bartels, Nicole Pfarr, Thomas Albrecht, Katharina Ilm, Jens Christmann, Anna‐Lena Volckmar, Hannah Goldschmid, Martina Kirchner, Michael Allgäuer, Maria Walker, Hans Kreipe, Andrea Tannapfel, Wilko Weichert, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 100-107 (2023)
Abstract Intrahepatic cholangiocarcinoma harbours druggable genetic lesions including FGFR2 gene fusions. Reliable and accurate detection of these fusions is becoming a critical component of the molecular work‐up, but real‐world data on the perfo
Externí odkaz:
https://doaj.org/article/766fefd6743746f48f23bf3da053da40
Autor:
Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. Methods Five commercially available parallel sequencing assays were evaluated for thei
Externí odkaz:
https://doaj.org/article/44bdb1f0d72743ee9374126053306f77
Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage ResponseSummary
Autor:
Victoria Neumeyer, Anna Brutau-Abia, Michael Allgäuer, Nicole Pfarr, Wilko Weichert, Christina Falkeis-Veits, Elisabeth Kremmer, Michael Vieth, Markus Gerhard, Raquel Mejías-Luque
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1071-1094 (2021)
Background & Aims: RING finger protein 43 (RNF43) is a tumor suppressor that frequently is mutated in gastric tumors. The link between RNF43 and modulation of Wingless-related integration site (WNT) signaling has not been shown clearly in the stomach
Externí odkaz:
https://doaj.org/article/472f9999d5b54f16995372b20c368717
Autor:
Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S. P. Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T. Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan, Philipp J. Jost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduc
Externí odkaz:
https://doaj.org/article/e72e961b8ad54302879663e878f7c62b
Autor:
Lucia Liotta, Sebastian Lange, H. Carlo Maurer, Kenneth P. Olive, Rickmer Braren, Nicole Pfarr, Sebastian Burger, Alexander Muckenhuber, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Helmut Friess, Roland Schmid, Hana Algül, Philipp J. Jost, Juliane Ramser, Christine Fischer, Anne S. Quante, Maximilian Reichert, Michael Quante
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
BACKGROUND Pancreatic cancer is one of the deadliest cancers, with low long-term survival rates. Despite recent advances in treatment, it is important to identify and screen high-risk individuals for cancer prevention. Familial pancreatic cancer (FPC
Externí odkaz:
https://doaj.org/article/8a61b9a6490f4bf589df9de33ae42926
Autor:
Jan Budczies, Nicole Pfarr, Eva Romanovsky, Volker Endris, Albrecht Stenzinger, Carsten Denkert
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-4 (2018)
Abstract Background Somatic copy number alterations (CNAs) contribute to the clinically targetable aberrations in the tumor genome. For both routine diagnostics and biomarkers research, CNA analysis in a single assay together with somatic mutations i
Externí odkaz:
https://doaj.org/article/cf8af959109b4b1e9a35d96da8de7863
Autor:
Nicole Pfarr
Publikováno v:
Trillium Pathology. :28-30
Molecular pathological examinations in the context of diagnostic analyses of tumour samples cover a broad spectrum of techniques for routine diagnostics. Especially in the last few years, there has been an increase in a large number of new biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71eada17748cd3765e28b93b18ca8927
https://doi.org/10.47184/tp.2023.01.06
https://doi.org/10.47184/tp.2023.01.06
Autor:
David Conrad, Alexandra Kehl, Christoph Beitzinger, Thomas Metzler, Katja Steiger, Nicole Pfarr, Konrad Fischer, Robert Klopfleisch, Heike Aupperle-Lellbach
Publikováno v:
Veterinary Sciences, Vol 9, Iss 2, p 56 (2022)
Canine digital melanoma, in contrast to canine oral melanoma, is still largely unexplored at the molecular genetic level. The aim of this study was to detect mutant genes in digital melanoma. Paraffin-embedded samples from 86 canine digital melanomas
Externí odkaz:
https://doaj.org/article/efb5360c39814cc6b061b2f024ab1253