Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Nicole, Manning"'
1
Akademický článek
PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia
Autor: Mark Wunderlich, Nicole Manning, Christina Sexton, Eric O’Brien, Luke Byerly, Cody Stillwell, John P. Perentesis, James C. Mulloy, Benjamin Mizukawa
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Immune therapies such as blinatumomab, CD19-directed bispecific CD3 T-cell Engager (BiTE), have resulted in significant improvements in outcomes for relapsed B-cell acute lymphoblastic leukemia (B-ALL). However, up to half of blinatumomab treated pat
Externí odkaz: https://doaj.org/article/5dda746341a54c8bacc19c67b5f3d649
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2
Akademický článek
Improved chemotherapy modeling with RAG-based immune deficient mice.
Autor: Mark Wunderlich, Nicole Manning, Christina Sexton, Anthony Sabulski, Luke Byerly, Eric O'Brien, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0225532 (2019)
We have previously characterized an acute myeloid leukemia (AML) chemotherapy model for SCID-based immune deficient mice (NSG and NSGS), consisting of 5 days of cytarabine (AraC) and 3 days of anthracycline (doxorubicin), to simulate the standard 7+3
Externí odkaz: https://doaj.org/article/cd47170d50ec4a2e8bcc41f4eec1940c
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3
PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets
Autor: Mark Wunderlich, Jing Chen, Christina Sexton, Nicole Manning, Luke Byerly, Eric O’Brien, John P. Perentesis, James C. Mulloy, Benjamin Mizukawa
As patient-derived xenograft (PDX) models of acute myeloid leukemia (AML) become increasingly common tools for preclinical evaluation of targeted therapies it becomes important to consider the fidelity with which this system recapitulates the disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05b09a4f36a4a29f9964a795e6b79e1d
https://doi.org/10.1101/2022.01.31.478534
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5
PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia
Autor: Cody Stillwell, Christina Sexton, John P. Perentesis, Mark Wunderlich, James C. Mulloy, Nicole Manning, Luke Byerly, Eric O'Brien, Benjamin Mizukawa
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Immune therapies such as blinatumomab, CD19-directed bispecific CD3 T-cell Engager (BiTE), have resulted in significant improvements in outcomes for relapsed B-cell acute lymphoblastic leukemia (B-ALL). However, up to half of blinatumomab treated pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da767e01ab6457d2df2156aa38a6c18
https://doi.org/10.3389/fonc.2021.642466
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6
Improved chemotherapy modeling with RAG-based immune deficient mice
Autor: Nicole Manning, James C. Mulloy, Benjamin Mizukawa, Christina Sexton, John P. Perentesis, Mark Wunderlich, Luke Byerly, Anthony Sabulski, Eric O'Brien
Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0225532 (2019)
PLoS ONE
We have previously characterized an acute myeloid leukemia (AML) chemotherapy model for SCID-based immune deficient mice (NSG and NSGS), consisting of 5 days of cytarabine (AraC) and 3 days of anthracycline (doxorubicin), to simulate the standard 7+3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f31d7a86c6b7763c228dd252e21703
https://doaj.org/article/cd47170d50ec4a2e8bcc41f4eec1940c
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7
Hybrid Three-Dimensional Lung Tissue Cultures to Improve Ex Vivo Models of Chronic Obstructive Pulmonary Disease
Autor: Nicole Manning, Tyler J. D’Ovidio, Chelsea M. Magin, Kolene E. Bailey, Melanie Koenigshoff
Rationale: Continued reliance on preclinical animal models and traditional human cell culture experiments conducted on supraphysiologically stiff surfaces in two dimensions often limits the translation of cellular and molecular mechanistic findings i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002aa0cb2c1866e25bb22c0becba6639
https://europepmc.org/articles/PMC6322000/
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8
Global Gene Expression and Mutation Signatures Are Preserved in PDX Models of Pediatric AML and Aid Discovery of Targeted Therapy for Cases with CBFA2T3/GLIS2 Rearrangement
Autor: Mark Wunderlich, Benjamin Mizukawa, James C. Mulloy, Jing Chen, Nicole Manning, Eric O'Brien, Luke Byerly, Christina Sexton, John P. Perentesis
Publikováno v: Blood. 134:3766-3766
Therapies for pediatric acute myeloid leukemia (AML) remain unsatisfactory and generally do not incorporate molecularly-targeted agents aside from FLT3 inhibitors outside of the relapse setting. Patient-derived xenograft (PDX) models of AML are incre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f740a428b191a50efae2646b161ab9d3
https://doi.org/10.1182/blood-2019-129225
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9
Utilizing experience-based co-design to improve the experience of patients accessing emergency departments in New South Wales public hospitals: An evaluation study
Autor: Nicole Manning, Rick Iedema, Jane Gray, Lee Holmes, Raj Verma, Donella Piper
Publikováno v: University of New England Australia
Summary Background This paper presents the findings of three multisite evaluations of Experience-Based Co-design (EBCD) programmes conducted in Emergency Departments (EDs) and associated departments in seven public hospitals in New South Wales, Austr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1959da22f507b8827d15265cb954a365
https://doi.org/10.1177/0951484812474247
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