Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nicole, Koutsodendris"'
Autor:
Ramsey Najm, Kelly A. Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A. Jones, Yadong Huang
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107962- (2020)
Summary: Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to
Externí odkaz:
https://doaj.org/article/f1316fb3a2d5436abc74d71efac9cd01
Autor:
Nicole Koutsodendris, Jessica Blumenfeld, Ayushi Agrawal, Michela Traglia, Brian Grone, Misha Zilberter, Oscar Yip, Antara Rao, Maxine R. Nelson, Yanxia Hao, Reuben Thomas, Seo Yeon Yoon, Patrick Arriola, Yadong Huang
Publikováno v:
Nature aging, vol 3, iss 3
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afe5e2b3e90921ae536bd6d7cbbba0d
https://escholarship.org/uc/item/3mn2s8w7
https://escholarship.org/uc/item/3mn2s8w7
Autor:
Yadong Huang, Alice Taubes, Marina Sirota, Tomiko Oskotsky, Misha Zilberter, Seo Yeon Yoon, Maureen E. Balestra, Jessica K De Freitas, Krishna Choudhary, Mesude Bicak, Benjamin S. Glicksberg, Brian P. Grone, Yanxia Hao, William Chang, Bin Chen, Ishan Paranjpe, Alice An, Celine Wang, Phil Nova, Emily Jones, Nuo Chen, Kelly A. Zalocusky, Nicole Koutsodendris, Fayzan Chaudhry, Silvia Pineda, Idit Kosti
Publikováno v:
Nature Aging. 1:932-947
The evident genetic, pathological and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug-repurposing screen for drugs to treat apolipoprotein E4 (APOE4)-related AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344ed394816c2d740eafbb790b588598
https://doi.org/10.1038/s43587-021-00122-7
https://doi.org/10.1038/s43587-021-00122-7
Autor:
Alice, Taubes, Phil, Nova, Kelly A, Zalocusky, Idit, Kosti, Mesude, Bicak, Misha Y, Zilberter, Yanxia, Hao, Seo Yeon, Yoon, Tomiko, Oskotsky, Silvia, Pineda, Bin, Chen, Emily A Aery, Jones, Krishna, Choudhary, Brian, Grone, Maureen E, Balestra, Fayzan, Chaudhry, Ishan, Paranjpe, Jessica, De Freitas, Nicole, Koutsodendris, Nuo, Chen, Celine, Wang, William, Chang, Alice, An, Benjamin S, Glicksberg, Marina, Sirota, Yadong, Huang
Publikováno v:
Nat Aging
The evident genetic, pathological, and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-related AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280579c1090f3d62b13565055133fa5b
https://pubmed.ncbi.nlm.nih.gov/36172600
https://pubmed.ncbi.nlm.nih.gov/36172600
Autor:
Maxine Nelson, Yadong Huang, Seo Yeon Yoon, Dah-Eun J Amornkul, Kelly A. Zalocusky, Alice An, Antara Rao, Nicole Koutsodendris, Olga Cisne-Thomson, Jason Bant, David A. Bennett, Qin Xu, Yanxia Hao, Ramsey Najm, Alice Taubes
Publikováno v:
Nature neuroscience, vol 24, iss 6
Selective neurodegeneration is a critical causal factor in Alzheimer's disease (AD); however, the mechanisms that lead some neurons to perish, whereas others remain resilient, are unknown. We sought potential drivers of this selective vulnerability u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a02ccbc05aec0ca64aa09e92e099b2
https://doi.org/10.1038/s41593-021-00851-3
https://doi.org/10.1038/s41593-021-00851-3
Publikováno v:
Annual review of pathology. 17
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves dysregulation of many cellular and molecular processes. It is notoriously difficult to develop therapeutics for AD due to its complex nature. Nevertheless, recent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff8a4ed769a5762c79357722d059883
https://pubmed.ncbi.nlm.nih.gov/34460318
https://pubmed.ncbi.nlm.nih.gov/34460318
Autor:
Seo Yeon Yoon, Yanxia Hao, Yadong Huang, Misha Zilberter, Kelly A. Zalocusky, Antara Rao, Maxine Nelson, Emily Jones, Alice Taubes, Nicole Koutsodendris, Ramsey Najm
Publikováno v:
SSRN Electronic Journal.
Despite its clear impact on Alzheimer’s Disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to model hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230a55c6b54153b06deb200cb3614b65
https://doi.org/10.2139/ssrn.3545529
https://doi.org/10.2139/ssrn.3545529
Autor:
Emily A. Aery Jones, Antara Rao, Misha Zilberter, Biljana Djukic, Jason S. Bant, Anna K. Gillespie, Nicole Koutsodendris, Maxine Nelson, Seo Yeon Yoon, Ky Huang, Heidi Yuan, Theodore M. Gill, Yadong Huang, Loren M. Frank
Publikováno v:
Cell reports, vol 37, iss 13
Cell Rep
Cell Rep
Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes – parvalbumin-expressing (PV(+)) and somatostatin-expressing (SST(+)) – differentially regulate end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca8c1fe8ca1a98a060f078812f2b820
https://doi.org/10.1016/j.celrep.2021.110159
https://doi.org/10.1016/j.celrep.2021.110159
Autor:
Marina Sirota, Alice An, Yadong Huang, Alice Taubes, Celine Wang, Phil Nova, Bin Chen, Tomiko Oskotsky, Maureen E. Balestra, Mesude Bicak, Yanxia Hao, Krishna Choudhary, Kelly A. Zalocusky, Benjamin S. Glicksberg, Ishan Paranjpe, Idit Kosti, Seo Yeon Yoon, Jessica K De Freitas, Nuo Chen, Fayzan Chaudhry, William Chang, Nicole Koutsodendris, Misha Zilberter, Emily Jones, Silvia Pineda, Brian P. Grone
Publikováno v:
Nature Aging. 1:1202-1202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea2c837eb6e79ee5f2fa2ecb961d38b
https://doi.org/10.1038/s43587-021-00144-1
https://doi.org/10.1038/s43587-021-00144-1
Autor:
Nicole Koutsodendris, Kelly A. Zalocusky, Yadong Huang, Alice Taubes, Antara Rao, Seo Yeon Yoon, Ramsey Najm, Maxine Nelson, Misha Zilberter, Emily Jones, Yanxia Hao
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107962-(2020)
Cell Rep
Cell Rep
Summary Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddce541c8b1da5d44d0debc51019f9d
https://doi.org/10.1016/j.celrep.2020.107962
https://doi.org/10.1016/j.celrep.2020.107962