Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Nicole, Kleinstreuer"'
Autor:
José T. Moreira-Filho, Dhruv Ranganath, Mike Conway, Charles Schmitt, Nicole Kleinstreuer, Kamel Mansouri
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-27 (2024)
Abstract With the increased availability of chemical data in public databases, innovative techniques and algorithms have emerged for the analysis, exploration, visualization, and extraction of information from these data. One such technique is chemic
Externí odkaz:
https://doaj.org/article/4e06f021754148c3877a42c8c5c607f5
Autor:
Kimberly T. To, Judy Strickland, Emily Reinke, Alexandre Borrel, Jim Truax, Heather Maldonado, Dave Allen, Nicole Kleinstreuer
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract Background Chemically induced skin sensitization, or allergic contact dermatitis, is a common occupational and public health issue. Regulatory authorities require an assessment of potential to cause skin sensitization for many chemical produ
Externí odkaz:
https://doaj.org/article/adb8f58888394cd0b2692c697f87c4c3
Autor:
Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Wibke Busch, Christian Desaintes, Anne Gourmelon, Roland Grafström, Joshua Harrill, Thomas Hartung, Matthias Herzler, George E.N. Kass, Nicole Kleinstreuer, Marcel Leist, Mirjam Luijten, Philip Marx-Stoelting, Oliver Poetz, Bennard van Ravenzwaay, Rob Roggeband, Vera Rogiers, Adrian Roth, Pascal Sanders, Russell S. Thomas, Anne Marie Vinggaard, Mathieu Vinken, Bob van de Water, Andreas Luch, Tewes Tralau
Publikováno v:
Environment International, Vol 178, Iss , Pp 108082- (2023)
The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance, sustainability, continued relevance for human health risk assessment and ethics of this system,
Externí odkaz:
https://doaj.org/article/f976f541aefc4b4e8d0e30fa3b873d98
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/79d31f61e8c64068a62b1e02882a57c0
Autor:
Amber B. Daniel, Neepa Choksi, Jaleh Abedini, Shannon Bell, Patricia Ceger, Bethany Cook, Agnes L. Karmaus, John Rooney, Kimberly T. To, David Allen, Nicole Kleinstreuer
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Humans are exposed to large numbers of chemicals during their daily activities. To assess and understand potential health impacts of chemical exposure, investigators and regulators need access to reliable toxicity data. In particular, reliable toxici
Externí odkaz:
https://doaj.org/article/21a1d5bc1e9a40dc960469e2b255c517
Autor:
Silvia Casati, David Asturiol, Patience Browne, Nicole Kleinstreuer, Michèle Régimbald-Krnel, Pierre Therriault
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
In the absence of stand-alone one-to-one replacements for existing animal tests, efforts were made to integrate data from in silico, in chemico and in vitro methods to ensure sufficient mechanistic coverage of the skin sensitisation Adverse Outcome P
Externí odkaz:
https://doaj.org/article/405e5bdae3ed4a38a4f1a1b537b6a45d
Autor:
Judy Strickland, James Truax, Marco Corvaro, Raja Settivari, Joseph Henriquez, Jeremy McFadden, Travis Gulledge, Victor Johnson, Sean Gehen, Dori Germolec, David G. Allen, Nicole Kleinstreuer
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Skin sensitization testing is a regulatory requirement for safety evaluations of pesticides in multiple countries. Globally harmonized test guidelines that include in chemico and in vitro methods reduce animal use, but no single assay is recommended
Externí odkaz:
https://doaj.org/article/5e4f422fb5ef4ae9acd0e208de74e8e1
Autor:
David E. Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen, Nicole Kleinstreuer
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill dat
Externí odkaz:
https://doaj.org/article/920f561cbdbe42558b98fe41907107e9
Autor:
José T. Moreira-Filho, Rodolpho C. Braga, Jade Milhomem Lemos, Vinicius M. Alves, Joyce V.V.B. Borba, Wesley S. Costa, Nicole Kleinstreuer, Eugene N. Muratov, Carolina Horta Andrade, Bruno J. Neves
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 1, Iss , Pp 100013- (2021)
Chemically induced toxicity is the leading cause of recent extinction of honey bees. In this regard, we developed an innovative artificial intelligence-based web app (BeeToxAI) for assessing the acute toxicity of chemicals to Apis mellifera. Initiall
Externí odkaz:
https://doaj.org/article/59a44a6d504f4ad5a3edf955f3796145
Autor:
Arthur C. Silva, Joyce V.V.B. Borba, Vinicius M. Alves, Steven U.S. Hall, Nicholas Furnham, Nicole Kleinstreuer, Eugene Muratov, Alexander Tropsha, Carolina Horta Andrade
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 1, Iss , Pp 100028- (2021)
Eye irritation and corrosion are fundamental considerations in developing chemicals to be used in or near the eye, from cleaning products to ophthalmic solutions. Unfortunately, animal testing is currently the standard method to identify compounds th
Externí odkaz:
https://doaj.org/article/ad54c918e2eb4cd0838c8e3d6622e4ac