Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nicole, Buschmann"'
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Activity of FGF401 in biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de614aa92fc53e000078388a9034229
https://doi.org/10.1158/1535-7163.22506502.v1
https://doi.org/10.1158/1535-7163.22506502.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Details on materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b9cca12680f3ffc27bb3edd85e4d5
https://doi.org/10.1158/1535-7163.22506505.v1
https://doi.org/10.1158/1535-7163.22506505.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
PK and PK/PD of FGF401 in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8adc6be4db10400fb7b3afdb43e38
https://doi.org/10.1158/1535-7163.22506514.v1
https://doi.org/10.1158/1535-7163.22506514.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
This file provides the full characterization of FGF401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3a6190c2b2732e54abfeea8a8dd793
https://doi.org/10.1158/1535-7163.22506520
https://doi.org/10.1158/1535-7163.22506520
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it is the third leading cause of cancer-related deaths worldwide. Recently, aberrant signaling through the FGF19/FGFR4 axis has been implicated in HCC. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e8f6230bcc0ef53c3f3f3f81212e3c
https://doi.org/10.1158/1535-7163.c.6538417.v1
https://doi.org/10.1158/1535-7163.c.6538417.v1
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9969a4c36550186a210fdfae8c1af415
https://doi.org/10.1021/acs.jmedchem.0c01245
https://doi.org/10.1021/acs.jmedchem.0c01245
Autor:
Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
Publikováno v:
Journal of Medicinal Chemistry. 63:12542-12573
FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key driver of growth and survival in a subset of hepatocellular carcinomas, making selective FGFR4 inhibition an attractive treatment opportunity. A kinome-wide seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e8386d5d1c6ff60ee10d825b90d6de
https://doi.org/10.1021/acs.jmedchem.0c01019
https://doi.org/10.1021/acs.jmedchem.0c01019
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c9148f487b1a8d48b0cb731fa2d9337
https://pubmed.ncbi.nlm.nih.gov/33252239
https://pubmed.ncbi.nlm.nih.gov/33252239
Autor:
Francesca Chiovaro, Manuela Bieri, Nicole Buschmann, Irina Agarkova, Mahomi Suzuki, Olivier Frey, Karen G. Dowell, Frauke Greve, Silvan Strebel, Judith Wardwell-Swanson, Eva C. Thoma
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(7)
Three-dimensional (3D) spheroid models are rapidly gaining favor for drug discovery applications due to their improved morphological characteristics, cellular complexity, long lifespan in culture, and higher physiological relevance relative to two-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcc75bec66d12181b1d5a7118309107
https://pubmed.ncbi.nlm.nih.gov/32484408
https://pubmed.ncbi.nlm.nih.gov/32484408
Autor:
Markus Kaufmann, Frédéric Baysang, Amanda Cobos-Correa, Pascal Furet, Therese-Marie Stachyra, Andreas Marzinzik, Nicole Buschmann, Pier Luca D’Alessandro, Johannes Ottl, Dimitrios Lizos, Reto Brunner, Thomas Vorherr
Publikováno v:
Angewandte Chemie International Edition. 55:16026-16030
To study the behavior of MDM2-p53 inhibitors in a disease-relevant cellular model, we have developed and validated a set of bioorthogonal probes that can be fluorescently labeled in cells and used in high-content screening assays. By using automated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359183fdfbd1c6747937d41f4409afe4
https://doi.org/10.1002/anie.201608568
https://doi.org/10.1002/anie.201608568