Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Nicole, Borth"'
Autor:
Witsanu Srila, Martina Baumann, Markus Riedl, Kuntalee Rangnoi, Nicole Borth, Montarop Yamabhai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The glutamine synthetase (GS)-based Chinese hamster ovary (CHO) selection system is an attractive approach to efficiently identify suitable clones in the cell line generation process for biologics manufacture, for which GS-knockout (GS-KO) C
Externí odkaz:
https://doaj.org/article/634b5ac1500f45ba9a77f93532cb87ff
Autor:
Marcus Weinguny, Gerald Klanert, Peter Eisenhut, Andreas Jonsson, Daniel Ivansson, Ann Lövgren, Nicole Borth
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1320-1329 (2020)
Chinese Hamster Ovary (CHO) cells are the working horse of the pharmaceutical industry. To obtain high producing cell clones and to satisfy regulatory requirements single cell cloning is a necessary step in cell line development. However, it is also
Externí odkaz:
https://doaj.org/article/232d6707f27a4be9977614512c8eb79d
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3632-3648 (2020)
Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable
Externí odkaz:
https://doaj.org/article/d1b0e2b0e5be40d29efe6b4a57cfd5c5
Autor:
Valerie Schmieder, Neža Novak, Heena Dhiman, Ly Ngoc Nguyen, Evgenija Serafimova, Gerald Klanert, Martina Baumann, Helene Faustrup Kildegaard, Nicole Borth
Publikováno v:
Biotechnology Reports, Vol 31, Iss , Pp e00649- (2021)
Chinese hamster ovary (CHO) cells are the most widely used host for the expression of therapeutic proteins. Recently, significant progress has been made due to advances in genome sequence and annotation quality to unravel the black box CHO. Neverthel
Externí odkaz:
https://doaj.org/article/12a1be4ab7124a27af33fa7b29cc47d4
Autor:
Elisabeth Gludovacz, Kornelia Schuetzenberger, Marlene Resch, Katharina Tillmann, Karin Petroczi, Markus Schosserer, Sigrid Vondra, Serhii Vakal, Gerald Klanert, Jürgen Pollheimer, Tiina A Salminen, Bernd Jilma, Nicole Borth, Thomas Boehm
Publikováno v:
eLife, Vol 10 (2021)
Background: Excessive plasma histamine concentrations cause symptoms in mast cell activation syndrome, mastocytosis, or anaphylaxis. Anti-histamines are often insufficiently efficacious. Human diamine oxidase (hDAO) can rapidly degrade histamine and
Externí odkaz:
https://doaj.org/article/d7281aa1f5af4be284b2a714515c12fb
Publikováno v:
Metabolic Engineering. 78:26-40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2e90c1a25221d0b4635fcbca4ab073
https://doi.org/10.1016/j.ymben.2023.05.003
https://doi.org/10.1016/j.ymben.2023.05.003
Autor:
Diana Széliová, Jerneja Štor, Isabella Thiel, Marcus Weinguny, Michael Hanscho, Gabriele Lhota, Nicole Borth, Jürgen Zanghellini, David E Ruckerbauer, Isabel Rocha
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009022 (2021)
Chinese hamster ovary (CHO) cells are the leading platform for the production of biopharmaceuticals with human-like glycosylation. The standard practice for cell line generation relies on trial and error approaches such as adaptive evolution and high
Externí odkaz:
https://doaj.org/article/3f6e3e27cbca41a8845046f16e44f498
Autor:
Miriam Klausberger, Mark Duerkop, Helmuth Haslacher, Gordana Wozniak-Knopp, Monika Cserjan-Puschmann, Thomas Perkmann, Nico Lingg, Patricia Pereira Aguilar, Elisabeth Laurent, Jelle De Vos, Manuela Hofner, Barbara Holzer, Maria Stadler, Gabriele Manhart, Klemens Vierlinger, Margot Egger, Lisa Milchram, Elisabeth Gludovacz, Nicolas Marx, Christoph Köppl, Christopher Tauer, Jürgen Beck, Daniel Maresch, Clemens Grünwald-Gruber, Florian Strobl, Peter Satzer, Gerhard Stadlmayr, Ulrike Vavra, Jasmin Huber, Markus Wahrmann, Farsad Eskandary, Marie-Kathrin Breyer, Daniela Sieghart, Peter Quehenberger, Gerda Leitner, Robert Strassl, Alexander E. Egger, Christian Irsara, Andrea Griesmacher, Gregor Hoermann, Günter Weiss, Rosa Bellmann-Weiler, Judith Loeffler-Ragg, Nicole Borth, Richard Strasser, Alois Jungbauer, Rainer Hahn, Jürgen Mairhofer, Boris Hartmann, Nikolaus B. Binder, Gerald Striedner, Lukas Mach, Andreas Weinhäusel, Benjamin Dieplinger, Florian Grebien, Wilhelm Gerner, Christoph J. Binder, Reingard Grabherr
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103348- (2021)
Background: Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection or vaccination. While first-generation antibody tests have primarily provided qualitative results, accurate seroprevalence studies and track
Externí odkaz:
https://doaj.org/article/ba1f6bc358354ac0a5baccc4ebc09bec
Autor:
Giulia Borsi, Krishna Motheramgari, Heena Dhiman, Martina Baumann, Elly Sinkala, Max Sauerland, Julian Riba, Nicole Borth
Publikováno v:
Journal of Biotechnology. 364:13-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc210d1263a95dae0f4d7b1a71ecb80a
https://doi.org/10.1016/j.jbiotec.2023.01.006
https://doi.org/10.1016/j.jbiotec.2023.01.006
Publikováno v:
Biotechnology and Bioengineering. 120:970-986
Mammalian cells frequently encounter subtle perturbations during recombinant protein production. Identifying the genetic factors that govern the cellular stress response can facilitate targeted genetic engineering to obtain production cell lines that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c4529d4171b184e49238bfb7e5be59
https://doi.org/10.1002/bit.28320
https://doi.org/10.1002/bit.28320