Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nicolau Beckman"'
Autor:
Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R. Shimshek
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. Heterozygous loss-of-function mutations in TREM2, including mutations enhancing s
Externí odkaz:
https://doaj.org/article/4cbb756a012a4e0da0d1168866d67a25
Autor:
Michael Obrecht, Stefan Zurbruegg, Nathalie Accart, Christian Lambert, Arno Doelemeyer, Birgit Ledermann, Nicolau Beckmann
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals. Minimizing their distress, reducing the
Externí odkaz:
https://doaj.org/article/9555f460d3f64bb6ac866e3ea49e2a90
Autor:
Nathalie Accart, Janet Dawson, Michael Obrecht, Christian Lambert, Manuela Flueckiger, Julie Kreider, Shinji Hatakeyama, Peter J. Richards, Nicolau Beckmann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The objective of this work was to assess the consequences of repeated intra-articular injection of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) in order to simulate recurrent bouts of gout in rats. Tr
Externí odkaz:
https://doaj.org/article/6ccf86dc007b45ae93bccbf17995c98e
Autor:
Nicolau Beckman
Publikováno v:
In Vivo MR Techniques in Drug Discovery and Development
Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance (MR) Imaging is one of the principal modalities since it allows anatomical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cd45e373f1cb1c25be99b5fe4290095
https://doi.org/10.3109/9781420004526
https://doi.org/10.3109/9781420004526
Autor:
Berangere Gapp, Marie Jourdain, Pauline Bringer, Benjamin Kueng, Delphine Weber, Arnaud Osmont, Stefan Zurbruegg, Judith Knehr, Rocco Falchetto, Guglielmo Roma, William Dietrich, Reginald Valdez, Nicolau Beckmann, Florian Nigsch, Arun J. Sanyal, Iwona Ksiazek
Publikováno v:
Hepatology Communications, Vol 4, Iss 1, Pp 109-125 (2020)
A promising approach for the treatment of nonalcoholic steatohepatitis (NASH) is the inhibition of enhanced hepatic de novo lipogenesis (DNL), which is the synthesis of fatty acids from nonlipid sources. This study assesses three approaches to DNL su
Externí odkaz:
https://doaj.org/article/f53881fedaa04196a137467b2582c5f6