Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Nicolas van Baren"'
Autor:
Loïc Rouaud, Louis Baudin, Marine Gautier-Isola, Pierre Van Meerbeeck, Emilie Feyereisen, Silvia Blacher, Nicolas van Baren, Frédéric Kridelka, Sophie Lucas, Agnes Noel
Publikováno v:
Cancers, Vol 15, Iss 23, p 5621 (2023)
Several types of cancer spread through the lymphatic system via the sentinel lymph nodes (LNs). Such LN-draining primary tumors, modified by tumor factors, lead to the formation of a metastatic niche associated with an increased number of Foxp3+ regu
Externí odkaz:
https://doaj.org/article/a454aaf5d8a148f79751546398a5770c
Autor:
Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and i
Externí odkaz:
https://doaj.org/article/8a55d3ad04c940c5ae3df3fd9a81d1dc
Autor:
Peter A. Johansson, Kelly Brooks, Felicity Newell, Jane M. Palmer, James S. Wilmott, Antonia L. Pritchard, Natasa Broit, Scott Wood, Matteo S. Carlino, Conrad Leonard, Lambros T. Koufariotis, Vaishnavi Nathan, Aaron B. Beasley, Madeleine Howlie, Rebecca Dawson, Helen Rizos, Chris W. Schmidt, Georgina V. Long, Hayley Hamilton, Jens F. Kiilgaard, Timothy Isaacs, Elin S. Gray, Olivia J. Rolfe, John J. Park, Andrew Stark, Graham J. Mann, Richard A. Scolyer, John V. Pearson, Nicolas van Baren, Nicola Waddell, Karin W. Wadt, Lindsay A. McGrath, Sunil K. Warrier, William Glasson, Nicholas K. Hayward
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a
Externí odkaz:
https://doaj.org/article/58e3d3d357e64515ab52e5174e676c01
Autor:
Charlotte Bertrand, Pierre Van Meerbeeck, Grégoire de Streel, Noora Vaherto-Bleeckx, Fatima Benhaddi, Loïc Rouaud, Agnès Noël, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
When combined with anti-PD-1, monoclonal antibodies (mAbs) against GARP:TGF-β1 complexes induced more frequent immune-mediated rejections of CT26 and MC38 murine tumors than anti-PD-1 alone. In both types of tumors, the activity of anti-GARP:TGF-β1
Externí odkaz:
https://doaj.org/article/f45f3173cc314e1ab9566494a2b0c62a
Autor:
Jingjing Zhu, Céline G. Powis de Tenbossche, Stefania Cané, Didier Colau, Nicolas van Baren, Christophe Lurquin, Anne-Marie Schmitt-Verhulst, Peter Liljeström, Catherine Uyttenhove, Benoit J. Van den Eynde
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by po
Externí odkaz:
https://doaj.org/article/03b05d3e6ab641c1b1de96121c6dfbee
Autor:
Nikenza Viceconte, Marie-Sophie Dheur, Eva Majerova, Christophe E. Pierreux, Jean-François Baurain, Nicolas van Baren, Anabelle Decottignies
Publikováno v:
Cell Reports, Vol 19, Iss 12, Pp 2529-2543 (2017)
Summary: Unlimited replicative potential is one of the hallmarks of cancer cells. In melanoma, hTERT (telomerase reverse transcriptase) is frequently overexpressed because of activating mutations in its promoter, suggesting that telomerase is necessa
Externí odkaz:
https://doaj.org/article/5cd459471a4d4d31bf46f48e839eb5df
Publikováno v:
Frontiers in Immunology, Vol 6 (2016)
Tryptophan is required for T lymphocyte effector functions. Its degradation is one of the mechanisms selected by tumors to resist immune destruction. Two enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase 1 (IDO1), control tryp
Externí odkaz:
https://doaj.org/article/4dc58964fd6c4df9a351fbf221876e28
Autor:
Pierre Vereecken, Frank Cornelis, Nicolas Van Baren, Valérie Vandersleyen, Jean-François Baurain
Publikováno v:
Dermatology Research and Practice, Vol 2012 (2012)
Many serum biomarkers have been evaluated in melanoma but their clinical significance remains a matter of debate. In this paper, a review of the serum biomarkers for melanoma will be detailed and will be discussed from the point of view of their prac
Externí odkaz:
https://doaj.org/article/a2d386bab29347c18b18b71c96c2aa9f
Autor:
Benoit J. Van den Eynde, Etienne Marbaix, Julie Lelotte, Nicolas van Baren, Jean-Christophe Renauld, Marie-Claire Letellier, Simon Klaessens, Marie Solvay, Aurélie Daumerie, Caroline Bouzin, Vincent Stroobant, Tereza Dvorakova, Delia Hoffmann
Supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e5b11eee0feb91d4c6a59bc085457d
https://doi.org/10.1158/2326-6066.22543315.v1
https://doi.org/10.1158/2326-6066.22543315.v1
Autor:
Benoit J. Van den Eynde, Etienne Marbaix, Julie Lelotte, Nicolas van Baren, Jean-Christophe Renauld, Marie-Claire Letellier, Simon Klaessens, Marie Solvay, Aurélie Daumerie, Caroline Bouzin, Vincent Stroobant, Tereza Dvorakova, Delia Hoffmann
Tryptophan catabolism is used by tumors to resist immune attack. It can be catalyzed by indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO). IDO1 is frequently expressed in tumors and has been widely studied as a potential therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0534b0fa3056295644db5fc99c26ad
https://doi.org/10.1158/2326-6066.c.6550213
https://doi.org/10.1158/2326-6066.c.6550213