Crystal structure of BtrK, a decarboxylase involved in the (S)-4-amino-2-hydroxybutyrate (AHBA) formation during butirosin biosynthesis

Autor: Laura A. Rivas Arenas, Fernanda C.R. de Paiva, Nicolas de O． Rossini, YanYan Li, Jonathan Spencer, Peter Leadlay, Marcio V.B. Dias

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Butirosin is an aminoglycoside that has an (S)-4-amino-2-hydroxybutyrate (AHBA) moiety capable of preventing the attack of several aminoglycoside modifying enzymes. The biosynthesis and the attachment of the AHBA to the 2-deoxystreptamine (2-DOS) inv

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https://doi.org/10.1016/j.molstruc.2022.133576