Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nicolas Zenker"'
Autor:
Lawrence B. Afrin, Nicolas Zenker
Publikováno v:
Blood. 126:5174-5174
Distinct from mastocytosis and simple allergy and characterized by constitutive mast cell (MC) activation and aberrant MC reactivity with little to no excessive MC accumulation, MC activation syndrome (MCAS) presents as acute-on-chronic multisystem p
Publikováno v:
Journal of Medicinal Chemistry. 35:548-552
Three novel thyroid hormone analogues: alpha-methyl-3,5,3'-triiodothyroacetic acid, alpha-methyl-3,5,3'-triiodothyropropionic acid, and alpha-methyl-3,5,3',5'-tetraiodothyropropionic acid were synthesized. The hepatic thyroid receptor affinity of the
Publikováno v:
Journal of Medicinal Chemistry. 21:72-78
The concept of bioisosterism between benzimidazole and catechol was applied to the design and synthesis of benzimidazole analogues of norepinephrine, (R,S)-1-[5(6)-benzimidazolyl]-2-aminoethanol (2), and of isoproterenol, (R,S)-1-[5(6)-benzimidazolyl
Publikováno v:
Journal of Natural Products. 51:862-865
RS-Goitrin can be conveniently prepared by a simplification of the Ettlinger procedure. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase. The administration of goitrin leads to a depression of brain norepinephrine
Publikováno v:
Enzyme. 42:73-79
Iodothyronine 5'-deiodinases were assayed in preparations of liver, cerebral cortex and brown adipose tissue. Rate profiles at various pH values revealed that methimazole activates the liver enzyme (type I) and inhibits the enzyme from brown adipose
Publikováno v:
Biochemical Pharmacology. 25:585-589
The intraperitoneal administration of DL -3-(5-benzimidazolyl)-2-methylalanine (MBA) causes a marked decline in rat brain and heart catecholamines. The release of tritiated norepinephrine from the rat heart by MBA indicates a release component in the
Publikováno v:
Life Sciences. 35:2213-2217
Liver thyronine 5′-deiodinase activity assayed in crude homogenates in the absence of dithiothreitol (DTT) is increased in rats killed by asphyxia when compared to that of animals killed by phenobarbital injection or decapitation. The addition of c
Autor:
Eugene C. Jorgensen, Nicolas Zenker
Publikováno v:
Journal of the American Chemical Society. 81:4643-4647
Autor:
Nicolas Zenker
Publikováno v:
Analytical Biochemistry. 2:89-99
A screening method for the estimation of uroporphyrin and total porphyrins has been presented and its merits and limitations evaluated. The Soret band behavior of coproporphyrin, uroporphyrin, and zinc uroporphyrin has been reviewed and discussed.
Publikováno v:
Biochemical Pharmacology. 21:1777-1783
Studies in vivo on benzimidazole-5(6)- dl -alanine were carried out by administering the compound in aqueous solutions intraperitoneally to male Wistar rats. Benzimidazole alanine (278 mg/kg) decreased heart norepinephrine (80 per cent), brain norepi