Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicolas Wyvekens"'
Autor:
Connie S. Zhong, MD, MSc, Nicolas Wyvekens, MD, PhD, Christine G. Lian, MD, Vinod E. Nambudiri, MD, MBA
Publikováno v:
JAAD Case Reports, Vol 28, Iss , Pp 107-109 (2022)
Externí odkaz:
https://doaj.org/article/a4f1c82577ac4a6c9f005ebe8ff94267
Autor:
Nicolas Wyvekens, Harrison K Tsai, Lynette M Sholl, Jonathan Tucci, Giovanna A Giannico, Jennifer B Gordetsky, Michelle S Hirsch, Justine A Barletta, Andres M Acosta
Publikováno v:
HistopathologyReferences. 80(7)
Mismatch repair (MMR) deficiency is commonly caused by functional inactivation of MLH1, PMS2, MSH2 or MSH6. The morphological and molecular correlates of MMR deficiency have been extensively characterized in certain tumour types such as colorectal an
Autor:
Dilara Akhoundova, Beda Mühleisen, Andreas M. Hötker, Nicolas Wyvekens, Niels J. Rupp, Birgit Maria Helmchen, Nadejda Valtcheva, Holger Moch, Achim Weber, Matthias Choschzick, Anita Rauch, Axel Mischo, Thomas Hermanns
The hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC) is defined by germline mutations in the fumarate hydratase (FH) gene and associated with leiomyomas and aggressive renal cell carcinomas with FH deficiency. Here, we comprehensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f091f3aca818d18a1304906a7b2e638
https://www.zora.uzh.ch/id/eprint/188760/
https://www.zora.uzh.ch/id/eprint/188760/
Autor:
Carina Wenzel, Markus Rechsteiner, Holger Moch, Joelle Tchinda, Ulrich Wagner, Friederike Kuithan, Christine Fritz, Nicolas Wyvekens, Lars-Christian Horn
Publikováno v:
Virchows Archiv : an international journal of pathology. 474(5)
The 2016 WHO Classification of Tumors of the Urinary System recognizes microphthalmia transcription factor (MiT) family translocation carcinomas as a separate entity among renal cell carcinomas. TFE3 and transcription factor EB (TFEB) are members of
Autor:
Martin J. Aryee, Matthew Liebers, Ved V Topkar, Cyd Khayter, Shengdar Q. Tsai, Long P. Le, Nhu T. Nguyen, Vishal Thapar, A. John Iafrate, Zongli Zheng, Nicolas Wyvekens, J. Keith Joung
Publikováno v:
Nature biotechnology
CRISPR RNA-guided nucleases (RGNs) are widely used genome-editing reagents, but methods to delineate their genome-wide, off-target cleavage activities have been lacking. Here we describe an approach for global detection of DNA double-stranded breaks
Autor:
Nicolas Wyvekens, J. Keith Joung, Shengdar Q. Tsai, Vishal Thapar, Cyd Khayter, Mathew J. Goodwin, Martin J. Aryee, Jennifer A Foden, Deepak Reyon
Publikováno v:
Nature biotechnology
Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we describe dimeric RNA-guided FokI Nucleases (RFNs) that recognize extended sequences and can edit e
Publikováno v:
Current Protocols in Molecular Biology
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system has been broadly adopted for highly efficient genome editing in a variety of model organisms and human cell types. Unlike previous genome editing tec
Autor:
Zongli Zheng, Ved V Topkar, Cyd Khayter, Nhu T. Nguyen, Vishal Thapar, Nicolas Wyvekens, Matthew Liebers, Shengdar Q. Tsai
Publikováno v:
Molecular Therapy. 23:S274
Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) RNA-guided nucleases (RGNs) have been broadly adopted by the scientific community for use as robust genome editing tools. However, CRISPR-Cas RGNs have been dem
Publikováno v:
Stem Cell Reviews
Pluripotent stem cells offer an abundant and malleable source for the generation of differentiated cells for transplantation as well as for in vitro screens. Patterning and differentiation protocols have been developed to generate neural progeny from