Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nicolas Wyhs"'
Autor:
Ashley L. Cook, Nicolas Wyhs, Surojit Sur, Blair Ptak, Maria Popoli, Laura Dobbyn, Tasos Papadopoulos, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shibin Zhou, Kenneth W. Kinzler
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104437- (2022)
Summary: We describe the creation of an isogenic cell line panel representing common cancer pathways, with features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cell lines were generated using CRISPR tec
Externí odkaz:
https://doaj.org/article/372f67ce56564615a5e03deb5b7a7da3
Autor:
Michael C. Haffner, David M. Esopi, Alcides Chaux, Meltem Gürel, Susmita Ghosh, Ajay M. Vaghasia, Harrison Tsai, Kunhwa Kim, Nicole Castagna, Hong Lam, Jessica Hicks, Nicolas Wyhs, Debika Biswal Shinohara, Paula J. Hurley, Brian W. Simons, Edward M. Schaeffer, Tamara L. Lotan, William B. Isaacs, George J. Netto, Angelo M. De Marzo, William G. Nelson, Steven S. An, Srinivasan Yegnasubramanian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acti
Externí odkaz:
https://doaj.org/article/41b0a231505343d098eefebb391e055f
Autor:
Hua Zhao, Yulan Cheng, Andrew Kalra, Ke Ma, Yueyuan Zheng, Benjamin Ziman, Caitlin Tressler, Kristine Glunde, Eun Ji Shin, Saowanee Ngamruengphong, Mouen Khashab, Vikesh Singh, Robert A. Anders, Simran Jit, Nicolas Wyhs, Wei Chen, Xu Li, De-Chen Lin, Stephen J. Meltzer
Publikováno v:
Science Translational Medicine. 14
Inactivation of the tumor suppressor genes tumor protein p53 ( TP53 ) and cyclin-dependent kinase inhibitor 2A ( CDKN2A ) occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, because of a paucity of GEJ-specific disease models,
Autor:
Hua Zhao, Yulan Cheng, Andrew Kalra, Ke Ma, Yueyuan Zheng, Benjamin Ziman, Caitlin Tressler, Kristine Glunde, Eun Ji Shin, Saowanee Ngamruengphong, Mouen Khashab, Vikesh Singh, Robert A. Anders, Simran Jit, Nicolas Wyhs, Wei Chen, Xu Li, De-Chen Lin, Stephen J. Meltzer
Inactivation of the tumor suppressor genes TP53 and CDKN2A occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, due to a paucity of GEJ-specific disease models, cancer-promoting consequences of TP53 and CDKN2A inactivation at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ab44ce4a24632fa2b7929756ffd6149
https://doi.org/10.1101/2022.05.10.491356
https://doi.org/10.1101/2022.05.10.491356
Autor:
Brian J. Mog, Sarah R. DiNapoli, Michael S. Hwang, Tushar D. Nichakawade, Jacqueline Douglass, Emily Han-Chung Hsiue, Katharine M. Wright, Alexander H. Pearlman, Maximilian F. Konig, Suman Paul, Nicolas Wyhs, Nikita Marcou, Stephanie Glavaris, Jiaxin Ge, Michelle S. Miller, P. Aitana Azurmendi, Evangeline Watson, Drew M. Pardoll, Sandra B. Gabelli, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou
Publikováno v:
Cancer Research. 83:LB095-LB095
Mutation-associated neoantigens (MANAs) are exquisitely cancer-specific therapeutic targets. However, MANAs are present at ultra-low densities on the cancer cell surface (as few as 1-2 copies per cell), leading to the challenge of eliciting a suffici
Autor:
David M. Esopi, Nicole Castagna, Ruedi Aebersold, Radhika A. Patel, Angelo M. De Marzo, Tiannan Guo, Gunes Guner, Harrison Tsai, Michael C. Haffner, Jessica Hicks, Ajay Vaghasia, William G. Nelson, Nicolas Wyhs, Jin-Yih Low, Minh-Tam Pham, Srinivasan Yegnasubramanian, Akshay Bhamidipati
Publikováno v:
The Prostate, 81 (15)
Prostate
Prostate
Background Resistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new preclinical models that allow the investigation of resistance mechanisms and the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ea4aa79165fe7e890ad85bb58beed2
https://hdl.handle.net/20.500.11850/501735
https://hdl.handle.net/20.500.11850/501735
Autor:
Ashley L. Cook, Nicolas Wyhs, Surojit Sur, Blair Ptak, Maria Popoli, Laura Dobbyn, Tasos Papadopoulos, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shibin Zhou, Kenneth W. Kinzler
Publikováno v:
iScience. 25(6)
We describe the creation of an isogenic cell line panel representing common cancer pathways, with features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cell lines were generated using CRISPR technologies
Autor:
Chetan Bettegowda, Surojit Sur, Blair Ptak, Laura Dobbyn, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W. Kinzler, Nicolas Wyhs, Tasos Papadopoulos, Ashley L. Cook, Maria Popoli, Shibin Zhou
SummaryWe describe the creation and characterization of an isogenic cell line panel representing common cancer pathways, with multiple features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cells were gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438e8d2579f60619816434723a3344b2
https://doi.org/10.1101/2021.08.06.455336
https://doi.org/10.1101/2021.08.06.455336
Autor:
Angelo M. De Marzo, Radhika A. Patel, Gunes Guner, Harrison Tsai, Minh-Tam Pham, Ruedi Aebersold, Tiannan Guo, Akshay Bhamidipati, David M. Esopi, Jessica Hicks, Ajay Vaghasia, Michael C. Haffner, Nicolas Wyhs, Jin-Yih Low, Nicole Castagna, Srinivasan Yegnasubramanian, William G. Nelson
BACKGROUNDResistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new pre-clinical models that allow the investigation of resistance mechanisms and the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16685d7af4fcbe84d72fcf445bd5999a
https://doi.org/10.1101/2021.07.04.450352
https://doi.org/10.1101/2021.07.04.450352
Autor:
Jianyong Liu, William G. Nelson, Hugh Giovinazzo, David M. Esopi, Akshay Bhamidipati, Nicolas Wyhs, Srinivasan Yegnasubramanian, Yash Jain, David Walker, Ajay Vaghasia, Jianya Zhou
Publikováno v:
Oncotarget
DNA methylation can mediate epigenetic silencing of tumor suppressor and cancer protective genes. The protein ubiquitin-like containing PHD and ring finger domains 1 (UHRF1) is an essential component in cells for DNA methylation maintenance. The SET-