Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nicolas Wenner"'
Autor:
Sam C. Went, David M. Picton, Richard D. Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T. F. Dryden, Darren L. Smith, Nicolas Wenner, Jay C. D. Hinton, Tim R. Blower
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognise and methylate 6 bp non-palindromic motifs within the host genome, and prevent
Externí odkaz:
https://doaj.org/article/f9d96556945641aca3006a94eb0b5cec
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011142 (2024)
Succinate is a potent immune signalling molecule that is present in the mammalian gut and within macrophages. Both of these infection niches are colonised by the pathogenic bacterium Salmonella enterica serovar Typhimurium during infection. Succinate
Externí odkaz:
https://doaj.org/article/7d3489286e6f4e229084eb204fe19ab0
Autor:
Mengru Yang, Nicolas Wenner, Gregory F. Dykes, Yan Li, Xiaojun Zhu, Yaqi Sun, Fang Huang, Jay C. D. Hinton, Lu-Ning Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Bacteria have evolved proteinaceous microcompartments (BMCs) to control the passage of metabolites and facilitate catabolism in a micro-environment. Here, Yang et al. apply fluorescence microscopy to characterize the protein-protein interaction and a
Externí odkaz:
https://doaj.org/article/6d193cbb22f14b70807d6e6b500ec4a7
Autor:
Mengru Yang, Deborah M. Simpson, Nicolas Wenner, Philip Brownridge, Victoria M. Harman, Jay C. D. Hinton, Robert J. Beynon, Lu-Ning Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Enteric pathogens such as Salmonella depend on propanediol-utilising microcompartments (Pdu MCP), which self-assemble from cytosolic proteins. Using mass spectrometry-based absolute quantification, the authors here define the protein stoichiometry an
Externí odkaz:
https://doaj.org/article/b8d56250827a4705bb5c667f33be65dc
Autor:
Jared D Honeycutt, Nicolas Wenner, Yan Li, Susan M Brewer, Liliana M Massis, Sky W Brubaker, Phoom Chairatana, Siân V Owen, Rocío Canals, Jay C D Hinton, Denise M Monack
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008763 (2020)
The various sub-species of Salmonella enterica cause a range of disease in human hosts. The human-adapted Salmonella enterica serovar Typhi enters the gastrointestinal tract and invades systemic sites to cause enteric (typhoid) fever. In contrast, mo
Externí odkaz:
https://doaj.org/article/3ea3abb68269426eb3b643d041618104
Autor:
Lizeth Lacharme-Lora, Siân V Owen, Richard Blundell, Rocío Canals, Nicolas Wenner, Blanca Perez-Sepulveda, Wai Yee Fong, Rachel Gilroy, Paul Wigley, Jay C D Hinton
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007540 (2019)
Over recent decades, Salmonella infection research has predominantly relied on murine infection models. However, in many cases the infection phenotypes of Salmonella pathovars in mice do not recapitulate human disease. For example, Salmonella Typhimu
Externí odkaz:
https://doaj.org/article/7619b0e213f646d79a0796d953ea6446
Autor:
Caisey V Pulford, Nicolas Wenner, Martha L Redway, Ella V Rodwell, Hermione J Webster, Roberta Escudero, Carsten Kröger, Rocío Canals, Will Rowe, Javier Lopez, Neil Hall, Paul D Rowley, Dorina Timofte, Robert A Harrison, Kate S Baker, Jay C D Hinton
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007169 (2019)
BackgroundReptile-associated Salmonella bacteria are a major, but often neglected cause of both gastrointestinal and bloodstream infection in humans globally. The diversity of Salmonella enterica has not yet been determined in venomous snakes, howeve
Externí odkaz:
https://doaj.org/article/5c0a7a8c705c455eb773f5aa66cb9cf2
Autor:
Rocío Canals, Disa L Hammarlöf, Carsten Kröger, Siân V Owen, Wai Yee Fong, Lizeth Lacharme-Lora, Xiaojun Zhu, Nicolas Wenner, Sarah E Carden, Jared Honeycutt, Denise M Monack, Robert A Kingsley, Philip Brownridge, Roy R Chaudhuri, Will P M Rowe, Alexander V Predeus, Karsten Hokamp, Melita A Gordon, Jay C D Hinton
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e3000059 (2019)
Salmonella Typhimurium sequence type (ST) 313 causes invasive nontyphoidal Salmonella (iNTS) disease in sub-Saharan Africa, targeting susceptible HIV+, malarial, or malnourished individuals. An in-depth genomic comparison between the ST313 isolate D2
Externí odkaz:
https://doaj.org/article/31ec980307d14f1684f15b5ba899d49a
Autor:
Ella V. Rodwell, Nicolas Wenner, Caisey V. Pulford, Yueyi Cai, Arthur Bowers-Barnard, Alison Beckett, Jonathan Rigby, David M. Picton, Tim R. Blower, Nicholas A. Feasey, Jay C. D. Hinton, Blanca M. Perez-Sepulveda
Publikováno v:
Viruses, Vol 13, Iss 3, p 478 (2021)
In recent years, novel lineages of invasive non-typhoidal Salmonella (iNTS) serovars Typhimurium and Enteritidis have been identified in patients with bloodstream infection in Sub-Saharan Africa. Here, we isolated and characterised 32 phages capable
Externí odkaz:
https://doaj.org/article/d61a794ea1774f13aafdd756e2cb167e
Autor:
Elisabeth Sonnleitner, Martina Valentini, Nicolas Wenner, Feth el Zahar Haichar, Dieter Haas, Karine Lapouge
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e44637 (2012)
The opportunistic human pathogen Pseudomonas aeruginosa is able to utilize a wide range of carbon and nitrogen compounds, allowing it to grow in vastly different environments. The uptake and catabolism of growth substrates are organized hierarchicall
Externí odkaz:
https://doaj.org/article/21bc6d356711413080db76aa0b2caf2c