Výsledky vyhledávání - "Nicolas Tokhadzé"

Akademický článek

Critical Drug Loss Induced by Silicone and Polyurethane Implantable Catheters in a Simulated Infusion Setup with Three Model Drugs

Autor: Nicolas Tokhadzé, Philip Chennell, Bruno Pereira, Bénédicte Mailhot-Jensen, Valérie Sautou

Publikováno v: Pharmaceutics, Vol 13, Iss 10, p 1709 (2021)

Silicone and polyurethane are biocompatible materials used for the manufacture of implantable catheters, but are known to induce drug loss by sorption, causing potentially important clinical consequences. Despite this, their impact on the drugs infus

Externí odkaz: https://doaj.org/article/e413474a387847aab0454cdcd01eedf3

Zobrazit plný text záznamu

Insulin Adsorption onto PE and PVC Tubings

Autor: Nicolas Tokhadzé, Meriem Sahnoune, Julien Devémy, Alain Dequidt, Florent Goujon, Philip Chennell, Valérie Sautou, Patrice Malfreyt

Publikováno v: ACS Applied Bio Materials
ACS Applied Bio Materials, 2022, ⟨10.1021/acsabm.2c00029⟩

International audience; We investigate the adsorption of insulin onto PE and PVC materials by using HPLC measurements and computer simulations. We interpret the experiments by calculating the Gibbs free energy profiles during the adsorption process.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd244d2716d5ad9379b6b80b196e48d2
https://pubmed.ncbi.nlm.nih.gov/35549028

Zobrazit plný text záznamu

Do plasticized polyvinylchloride and polyurethane infusion sets promote infliximab adsorption?

Autor: Valérie Sautou, Nicolas Tokhadzé, Philip Chennell

Publikováno v: Pharmaceutical Technology in Hospital Pharmacy, Vol 5, Iss 1, Pp 421-31 (2020)

ObjectivesInfliximab diluted solutions have been shown to be physicochemically stable for long periods, however the adsorption of infliximab during infusions has not been readily investigated. This study aimed to evaluate potential adsorption phenome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938dd87d144219388304d792207c177
https://doaj.org/article/f92e2247180c44498cc1da2739015d24

Zobrazit plný text záznamu

Drug Interactions with Plasticized PVCs

Autor: Meriem Sahnoune, Nicolas Tokhadzé, Sarah Ech Cherif El Kettani, Julien Devémy, Florent Goujon, Philip Chennell, Alain Dequidt, Christelle Goutaudier, Valérie Sautou, Patrice Malfreyt

Publikováno v: ACS Applied Polymer Materials
ACS Applied Polymer Materials, In press, ⟨10.1021/acsapm.2c00532⟩

International audience; Identifying the parameters that can impact the sorption of drugs to polymer materials is critical to design medical devices which would prevent drug loss by sorption. We propose a combined approach based on advanced molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d5f1eac1f5647260925a10ebe80a0c
https://hal.science/hal-03682638

Zobrazit plný text záznamu

Physicochemical Stability of Monoclonal Antibodies: A Review

Autor: Philip Chennell, Nicolas Tokhadzé, Valérie Sautou, Alain Astier, Yoann Le Basle

Publikováno v: Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, Wiley, 2020, ⟨10.1016/j.xphs.2019.08.009⟩
Journal of Pharmaceutical Sciences, 2020, ⟨10.1016/j.xphs.2019.08.009⟩

Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature. In this work, we review the different mechanisms that can be linked to monoclonal antibodies instability, the parameters, and conditions affecting their st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cfb278f98b2942d6514e83ee773565
https://doi.org/10.1016/j.xphs.2019.08.009

Zobrazit plný text záznamu

Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release

Autor: Nicolas Tokhadzé, Bénédicte Mailhot-Jensen, Bruno Jorge Pereira, Valérie Sautou, Philip Chennell, Céline Lambert, Laurence Bernard

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-55113-x⟩
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-55113-x⟩

Medical tubings in plasticized polyvinylchloride (PVC) are widely used for the infusion of medications but are known in some cases to cause content-container interactions (drug sorption and plasticizer release). The aim of this study was to assess in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923c241f738ea44674a1b03c6ad02a38
http://link.springer.com/article/10.1038/s41598-019-55113-x

Zobrazit plný text záznamu

Plný text ve formátu HTML

Understanding and characterizing the drug sorption to PVC and PE materials

Autor: Nicolas Tokhadzé, Julien Devémy, Patrice Malfreyt, Alain Dequidt, Meriem Sahnoune, Philip Chennell, Valérie Sautou, Florent Goujon

Publikováno v: ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2021, 13, pp.18594-18603. ⟨10.1021/acsami.1c03284⟩
ACS Applied Materials & Interfaces, 2021, 13, pp.18594-18603. ⟨10.1021/acsami.1c03284⟩

Characterizing the sorption of drugs onto polyvinylchloride (PVC) and polyethylene (PE) materials in terms of thermodynamic adsorption properties and atomistic details (local arrangements, orientation, and diffusion) is fundamental for the developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6da71aa71e15f0c3a616a703373a9d
https://hal.uca.fr/hal-03229994

Zobrazit plný text záznamu

Stability of infliximab solutions in different temperature and dilution conditions

Autor: Yoann Le Basle, Valérie Sautou, Philip Chennell, Nicolas Tokhadzé

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2018, 150, pp.386-395. ⟨10.1016/j.jpba.2017.12.012⟩
Journal of Pharmaceutical and Biomedical Analysis, 2018, 150, pp.386-395. ⟨10.1016/j.jpba.2017.12.012⟩

International audience; Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f824f3ebbc17e7500537683fa7e516ca
https://doi.org/10.1016/j.jpba.2017.12.012

Zobrazit plný text záznamu

Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?

Autor: Nicolas Tokhadzé, Régis Cueff, Philip Chennell, Valérie Sautou

Publikováno v: J R Soc Interface

This work aims to evaluate the possible impact of interactions between bevacizumab solutions and an implantable port equipped with a silicone or a polyurethane catheter after infusion through a complete infusion set-up in simulated use conditions. Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1259e3bd45a6cddb9d78788ced7144d
https://doi.org/10.1098/rsif.2018.0721

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání