Výsledky vyhledávání - "Nicolas Tanguy"

Akademický článek

Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation

Autor: Ludmila Recoules, Nicolas Tanguy Le Gac, Fatima Moutahir, Kerstin Bystricky, Anne-Claire Lavigne

Publikováno v: Cells, Vol 12, Iss 17, p 2175 (2023)

Heterochromatin formation plays a pivotal role in regulating chromatin organization and influences nuclear architecture and genome stability and expression. Amongst the locations where heterochromatin is found, the pericentric regions have the capabi

Externí odkaz: https://doaj.org/article/b7fb4a1a9a4848ed8141de1a288afbcd

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Akademický článek

Addressing the role of centromere sites in activation of ParB proteins for partition complex assembly.

Autor: Sylvain Audibert, Nicolas Tanguy-le-Gac, Jérôme Rech, Catherine Turlan, Jean-Yves Bouet, Kerstin Bystricky, David Lane

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0226472 (2020)

The ParB-parS partition complexes that bacterial replicons use to ensure their faithful inheritance also find employment in visualization of DNA loci, as less intrusive alternatives to fluorescent repressor-operator systems. The ability of ParB molec

Externí odkaz: https://doaj.org/article/6480096400254ff7860139c19c1a2c9e

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Akademický článek

Differential chromosome conformations as hallmarks of cellular identity revealed by mathematical polymer modeling.

Autor: Imen Lassadi, Alain Kamgoué, Isabelle Goiffon, Nicolas Tanguy-le-Gac, Kerstin Bystricky

Publikováno v: PLoS Computational Biology, Vol 11, Iss 6, p e1004306 (2015)

Inherently dynamic, chromosomes adopt many different conformations in response to DNA metabolism. Models of chromosome organization in the yeast nucleus obtained from genome-wide chromosome conformation data or biophysical simulations provide importa

Externí odkaz: https://doaj.org/article/4fe6ae461b674366b8519076b2b49a49

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Akademický článek

DNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cells.

Autor: Hicham Saad, Franck Gallardo, Mathieu Dalvai, Nicolas Tanguy-le-Gac, David Lane, Kerstin Bystricky

Publikováno v: PLoS Genetics, Vol 10, Iss 3, p e1004187 (2014)

Chromosome breakage is a major threat to genome integrity. The most accurate way to repair DNA double strand breaks (DSB) is homologous recombination (HR) with an intact copy of the broken locus. Mobility of the broken DNA has been seen to increase d

Externí odkaz: https://doaj.org/article/3bcfe8119b74426ca2f419e6c91a1213

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Akademický článek

Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex.

Autor: Giuseppe Villani, Igor Shevelev, Eleonora Orlando, Helmut Pospiech, Juhani E Syvaoja, Enni Markkanen, Ulrich Hubscher, Nicolas Tanguy Le Gac

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93908 (2014)

DNA polymerase ε (pol ε) is believed to be the leading strand replicase in eukaryotes whereas pols λ and β are thought to be mainly involved in re-synthesis steps of DNA repair. DNA elongation by the human pol ε is halted by an abasic site (apur

Externí odkaz: https://doaj.org/article/7b559f9d552e47b6b5eda7eab0621523

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