Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Nicolas Tajeddine"'
Autor:
Georges Chehade, Nady El Hajj, Mohamed Aittaleb, Maisa I. Alkailani, Yosra Bejaoui, Asma Mahdi, Arwa A. H. Aldaalis, Michael Verbiest, Julie Lelotte, Nuria Ruiz-Reig, Irene Durá, Christian Raftopoulos, Nicolas Tajeddine, Fadel Tissir
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundGlioblastoma is one of the most aggressive primary brain tumors, with a poor outcome despite multimodal treatment. Methylation of the MGMT promoter, which predicts the response to temozolomide, is a well-established prognostic marker for gl
Externí odkaz:
https://doaj.org/article/1369f93b831e4ee098f1f9224cf0cca6
Autor:
Anna Kreis, Farah Issa, Xavier Yerna, Caren Jabbour, Olivier Schakman, Marie de Clippele, Nicolas Tajeddine, Nathalie Pierrot, Jean-Noël Octave, Roberta Gualdani, Philippe Gailly
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into p
Externí odkaz:
https://doaj.org/article/20af515e71b6444192b6522210975573
Autor:
Anna Kreis, Jana Desloovere, Nuria Suelves, Nathalie Pierrot, Xavier Yerna, Farah Issa, Olivier Schakman, Roberta Gualdani, Marie de Clippele, Nicolas Tajeddine, Pascal Kienlen-Campard, Robrecht Raedt, Jean-Noël Octave, Philippe Gailly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The function of the amyloid precursor protein (APP) is not fully understood, but its cleavage product amyloid beta (Aβ) together with neurofibrillary tangles constitute the hallmarks of Alzheimer’s disease (AD). Yet, imbalance of excitato
Externí odkaz:
https://doaj.org/article/8573bf1d0f514383a0caa67d43212752
Autor:
Eva On-Chai Lau, Devid Damiani, Georges Chehade, Nuria Ruiz-Reig, Rana Saade, Yves Jossin, Mohamed Aittaleb, Olivier Schakman, Nicolas Tajeddine, Philippe Gailly, Fadel Tissir
Publikováno v:
eLife, Vol 10 (2021)
Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the capacity to nucleate and elongate actin filaments and, therefore, to remodel the cytoskeleton. DIAPH3 is essential for cytokinesis as its dysfunction impairs the contr
Externí odkaz:
https://doaj.org/article/de76d6fb42264b29a8ccdd3a42ddfd9d
Autor:
Sophie Lepannetier, Roberta Gualdani, Sabrina Tempesta, Olivier Schakman, François Seghers, Anna Kreis, Xavier Yerna, Amina Slimi, Marie de Clippele, Nicolas Tajeddine, Thomas Voets, Robin S. Bon, David J. Beech, Fadel Tissir, Philippe Gailly
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Group I metabotropic glutamate receptors, in particular mGluR5, have been implicated in various forms of synaptic plasticity that are believed to underlie declarative memory. We observed that mGluR5 specifically activated a channel containing TRPC1,
Externí odkaz:
https://doaj.org/article/b2b123bfce2440ceab2609b56652b5b8
Publikováno v:
Cancers, Vol 12, Iss 8, p 2023 (2020)
The authors wish to make the following corrections to this paper [...]
Externí odkaz:
https://doaj.org/article/d2a02e0eb9104e0ea075229f7013195e
Autor:
Xavier Yerna, Olivier Schakman, Ikram Ratbi, Anna Kreis, Sophie Lepannetier, Marie de Clippele, Younès Achouri, Nicolas Tajeddine, Fadel Tissir, Roberta Gualdani, Philippe Gailly
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1712 (2020)
Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic plasticity that are believed to underlie declarative memory. We previously showed that mGluR5 specifically activates channels containing TRPC1, an isoform of t
Externí odkaz:
https://doaj.org/article/8e14f08f2515411aa3999468d10f5162
Publikováno v:
Cancers, Vol 11, Iss 3, p 430 (2019)
Cisplatin (CDDP) is one of the principal chemotherapeutic agents used for the first-line treatment of many malignancies, including non-small cell lung carcinoma (NSCLC). Despite its use for over 40 years, its mechanism of action is not yet fully unde
Externí odkaz:
https://doaj.org/article/26ffa120c6f945c0a5472e671b2ca7b4
Autor:
Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken André Olaussen, Guillaume Pinna, Tobias Eisenberg, Aïcha Goubar, Isabelle Martins, Judith Michels, Gueorgui Kratassiouk, Didac Carmona-Gutierrez, Marie Scoazec, Erika Vacchelli, Frederic Schlemmer, Oliver Kepp, Shensi Shen, Maximilien Tailler, Mireia Niso-Santano, Eugenia Morselli, Alfredo Criollo, Sandy Adjemian, Mohamed Jemaà, Kariman Chaba, Claire Pailleret, Mickaël Michaud, Federico Pietrocola, Nicolas Tajeddine, Thibault de La Motte Rouge, Natalia Araujo, Nadya Morozova, Thomas Robert, Hugues Ripoche, Frederic Commo, Benjamin Besse, Pierre Validire, Pierre Fouret, Angélique Robin, Nicolas Dorvault, Philippe Girard, Sébastien Gouy, Patricia Pautier, Nora Jägemann, Ann-Christin Nickel, Sabrina Marsili, Caroline Paccard, Nicolas Servant, Philippe Hupé, Carmen Behrens, Parviz Behnam-Motlagh, Kimitoshi Kohno, Isabelle Cremer, Diane Damotte, Marco Alifano, Øivind Midttun, Per Magne Ueland, Vladimir Lazar, Philippe Dessen, Hans Zischka, Etienne Chatelut, Maria Castedo, Frank Madeo, Emmanuel Barillot, Juergen Thomale, Ignacio Ivan Wistuba, Catherine Sautès-Fridman, Laurence Zitvogel, Jean-Charles Soria, Annick Harel-Bellan, Guido Kroemer
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 257-269 (2012)
Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and i
Externí odkaz:
https://doaj.org/article/c962346fede94134a0ec7d5f7e6f4ffd
Autor:
Georges Chehade, Tévi Morel Lawson, Julie Lelotte, Lina Daoud, Dario Di Perri, Nicolas Whenham, Thierry Duprez, Nicolas Tajeddine, Fadel Tissir, Christian Raftopoulos
Publikováno v:
Acta Neurochirurgica. 165:1075-1085