Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide.

Autor: Silvia Diaz-Perez, Nathanael Kane, Alexis A Kurmis, Fei Yang, Nicolas T Kummer, Peter B Dervan, Nicholas G Nickols

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196803 (2018)

Pyrrole-imidazole (Py-Im) polyamides are synthetic non-genotoxic minor groove-binding small molecules. We hypothesized that Py-Im polyamides can modulate the cellular response to ionizing radiation. Pre-treatment of cells with a Py-Im polyamide prior

Externí odkaz: https://doaj.org/article/a69e65bb62d345b58c3bae12d04a0bc8

Inhibition of uPAR and uPA reduces invasion in papillary thyroid carcinoma cells

Autor: Theodore S. Nowicki, Codrin Iacob, Nina Suslina, Steven David Schaefer, Jan Geliebter, Raj K. Tiwari, Nicolas T. Kummer, Stimson P. Schantz, Edward Shin, Augustine Moscatello

Publikováno v: The Laryngoscope. 120:1383-1390

Objectives/Hypothesis: We analyzed the expression of urokinase plasminogen activator (uPA) and its receptor (uPAR) in papillary thyroid carcinoma (PTC) and normal thyroid tissue and examined in vitro how uPA and uPAR contribute to an invasive/metasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77c321cc443c2df9db4dba7f2d8dd921
https://doi.org/10.1002/lary.20915

Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics

Autor: Ruedi Aebersold, Marjorie Brand, Nicolas T Kummer, Mark Groudine, Jeffrey A. Ranish, Kazuhiko Igarashi, Joan Hamilton, Claire Francastel, Tian Chi, Gerald R. Crabtree

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2004, 11 (1), pp.73-80. ⟨10.1038/nsmb713⟩

During erythroid differentiation, beta-globin gene expression is regulated by the locus control region (LCR). The transcription factor NF-E2p18/MafK binds within this region and is essential for beta-globin expression in murine erythroleukemia (MEL)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8470c1210e4f87b6cd62bac1757a985d
https://hal.archives-ouvertes.fr/hal-03081747

Abstract 520: Inhibition of uPAR and uPA reduces invasion and degradative potential in papillary thyroid carcinoma cells

Autor: Augustine Moscatello, Stimson P. Schantz, Jan Geliebter, Steven D. Schaefer, Raj K. Tiwari, Codrin Iacob, Theodore S. Nowicki, Nina Suslina, Nicolas T. Kummer, Edward Shin

Publikováno v: Cancer Research. 70:520-520

Papillary thyroid cancer (PTC) is the most prevalent endocrine and thyroid malignancy. The ability of PTC to invade and migrate great distances contributes to distant metastases, which represent the most common cause of PTC-related death. The urokina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec0f3e410a8bf8f11535bf47969ae550
https://doi.org/10.1158/1538-7445.am10-520