Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Nicolas Sluis-Cremer"'
Autor:
Alondra Vázquez Rivera, Heather Donald, Mounia Alaoui-El-Azher, John J. Skoko, John S. Lazo, Michael A. Parniak, Paul A. Johnston, Nicolas Sluis-Cremer
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 819 (2024)
The ribonuclease H (RNase H) active site of HIV-1 reverse transcriptase (RT) is the only viral enzyme not targeted by approved antiretroviral drugs. Using a fluorescence-based in vitro assay, we screened 65,239 compounds at a final concentration of 1
Externí odkaz:
https://doaj.org/article/f8e64f106e54456d83df7089a79fcab8
Publikováno v:
Viruses, Vol 15, Iss 12, p 2347 (2023)
Antiretroviral therapy (ART) provides an effective method for managing HIV-1 infection and preventing the onset of AIDS; however, it is ineffective against the reservoir of latent HIV-1 that persists predominantly in resting CD4+ T cells. Understandi
Externí odkaz:
https://doaj.org/article/7edf0050fcdd4f0ab4e57c6c05b3e49c
Autor:
Benni Vargas, Nicolas Sluis-Cremer
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
The persistence of latent, replication-competent HIV-1 proviruses in resting CD4+ T cells, and other cellular reservoirs, represents a major barrier to a cure. This reservoir is impervious to the immune system and to antiretroviral therapy, but has t
Externí odkaz:
https://doaj.org/article/77143721c44d42a88323b4125c91f79f
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 100 (2023)
The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity t
Externí odkaz:
https://doaj.org/article/5d173feb9e6b42408c8235f1ee1f7967
Autor:
Jan Kristoff, Mariana L. Palma, Tatiana M. Garcia-Bates, Chengli Shen, Nicolas Sluis-Cremer, Phalguni Gupta, Charles R. Rinaldo, Robbie B. Mailliard
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 295-306 (2019)
Background: Despite the success of antiretroviral therapy (ART), latent HIV-1 continues to persist in a long-lived population of resting memory CD4+ T cells within those who are infected. Finding a safe and effective means to induce latency reversal
Externí odkaz:
https://doaj.org/article/bf3cb0e7aa5a452fabd01ba01eb02660
Autor:
Abigail Gerberick, Diana C. DeLucia, Paolo Piazza, Mounia Alaoui-El-Azher, Charles R. Rinaldo, Nicolas Sluis-Cremer, Giovanna Rappocciolo
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-compe
Externí odkaz:
https://doaj.org/article/11fccc6919ab45b0891ec2ca00492129
Autor:
Yan Guo, Adam D. Tomich, Christi L. McElheny, Vaughn S. Cooper, Amelia Tait-Kamradt, Min Chen, Fupin Hu, Louis B. Rice, Nicolas Sluis-Cremer, Yohei Doi
Publikováno v:
Emerging Infectious Diseases, Vol 23, Iss 11, Pp 1902-1904 (2017)
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-ac
Externí odkaz:
https://doaj.org/article/4f9954a1008f45e5b42d25d56b559fc1
Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene
Autor:
Ryota Ito, Mustapha M. Mustapha, Adam D. Tomich, Jake D. Callaghan, Christi L. McElheny, Roberta T. Mettus, Robert M. Q. Shanks, Nicolas Sluis-Cremer, Yohei Doi
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn2+ and K+-dependent glutathione S-transferases which confe
Externí odkaz:
https://doaj.org/article/800591cac5b2456d90b934759a38ffd9
Autor:
Nicolas Sluis-Cremer
Publikováno v:
Viruses, Vol 6, Iss 8, Pp 2960-2973 (2014)
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are widely used to treat HIV-1-infected individuals; indeed most first-line antiretroviral therapies typically include one NNRTI in combination with two nucleoside analogs. In 2008, the next-gen
Externí odkaz:
https://doaj.org/article/294a66db67b5403b8ab48bc7a1ea5686