Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nicolas Severe"'
Autor:
Viktor Petukhov, Jimin Guo, Ninib Baryawno, Nicolas Severe, David T. Scadden, Maria G. Samsonova, Peter V. Kharchenko
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Recent single-cell RNA-seq protocols based on droplet microfluidics use massively multiplexed barcoding to enable simultaneous measurements of transcriptomes for thousands of individual cells. The increasing complexity of such data creates c
Externí odkaz:
https://doaj.org/article/8f66bdabf8444db2b493fd8545e0354d
Autor:
Sandra S. McAllister, David T. Scadden, Robert E. Coleman, Janet E. Brown, Ingunn Holen, Ana C. Garrido-Castro, Walter M. Gregory, Yuanbo Qin, Catherine S. Rhee, Marie-Therese Haider, John N. Hutchinson, Jaclyn Sceneay, Molly J. DeCristo, Nicolas Severe, Ninib Baryawno, Jessalyn M. Ubellacker
Supplemental Figure 1 shows the tumor masses of the subcutaneous tumors shown in Figure 1, as well as the flow cytometry gating strategy of M/OCP populations and the osteoclast differentiation assay experimental schematic. Supplemental Figure 2 shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9f95d1649bc441c5a0ff4e4e93ee25
https://doi.org/10.1158/0008-5472.22419630.v1
https://doi.org/10.1158/0008-5472.22419630.v1
Autor:
Sandra S. McAllister, David T. Scadden, Robert E. Coleman, Janet E. Brown, Ingunn Holen, Ana C. Garrido-Castro, Walter M. Gregory, Yuanbo Qin, Catherine S. Rhee, Marie-Therese Haider, John N. Hutchinson, Jaclyn Sceneay, Molly J. DeCristo, Nicolas Severe, Ninib Baryawno, Jessalyn M. Ubellacker
Functionally enriched gene ontology (GO) terms and differentially enriched genes for the RNA-sequencing tables and heatmaps included in the manuscript text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e12745264ba02f07bbbb549c2e478d9
https://doi.org/10.1158/0008-5472.22419633.v1
https://doi.org/10.1158/0008-5472.22419633.v1
Autor:
Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee, Nicolas Severe, Brody H. Foy, Fadi E. Pulous, Shuang Zhang, Konstantinos D. Kokkaliaris, Vanessa Frodermann, Gabriel Courties, Chongbo Yang, Yoshiko Iwamoto, Anders Steen Knudsen, Cameron S. McAlpine, Masahiro Yamazoe, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Karin Gustafsson, Diane Capen, Dennis Brown, John M. Higgins, David T. Scadden, Peter Libby, Filip K. Swirski, Kamila Naxerova, Matthias Nahrendorf
Publikováno v:
Nature Immunology. 23:605-618
Autonomic nerves control organ function through the sympathetic and parasympathetic branches, which have opposite effects. In the bone marrow, sympathetic (adrenergic) nerves promote hematopoiesis; however, how parasympathetic (cholinergic) signals m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75965aa3eb931cfbf355a147f0074cfc
https://doi.org/10.1038/s41590-022-01165-7
https://doi.org/10.1038/s41590-022-01165-7
Autor:
Karin Gustafsson, Sergey Isaev, Kameron A. Kooshesh, Ninib Baryawno, Konstantinos D. Kokkaliaris, Nicolas Severe, Ting Zhao, Elizabeth W. Scadden, Joel A. Spencer, Christian Burns, Kumaran Akilan, Nikolaos Barkas, Hayalneh Gessessew, Charles P. Lin, Peter V. Kharchenko, David T. Scadden
Thymic atrophy and the progressive immune decline that accompanies it is a major health problem, chronically with age and acutely with immune injury. No solution has been defined. Here we demonstrate that one of the three mesenchymal cell subsets ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c0bfb6f15ea8e6e215309d5b9b5b02
https://doi.org/10.1101/2022.10.12.511184
https://doi.org/10.1101/2022.10.12.511184
Autor:
Kamila Naxerova, Hajera Amatullah, Vanessa Frodermann, Gerard Pasterkamp, I-Hsiu Lee, Fanny Herisson, Nicolas Severe, David Rohde, Gregory R. Wojtkiewicz, Paul M. Ridker, Jana Grune, Friedrich Felix Hoyer, Matthias Nahrendorf, Saskia C. A. de Jager, Yoshiko Iwamoto, Karin Gustafsson, Peter Libby, Lisa Honold, Sebastian Cremer, Gustavo Santos Masson, Ruslan I. Sadreyev, Shuang Zhang, Kate L. Jeffrey, Filip K. Swirski, Gabriel Courties, Fei Ji, Cameron S. McAlpine, Stephen P. Schmidt, Maximilian J. Schloss, Jean G. MacFadyen, Ian D. van Koeverden, David T. Scadden
Publikováno v:
Nature Medicine, 25(11), 1761. Nature Publishing Group
Nature Medicine
Nature Medicine
A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences leukocyte production. Here we show that voluntary running decreases hematopoietic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fd2c0f94178e80ee3c40dba83abc1e
https://doi.org/10.1038/s41591-019-0633-x
https://doi.org/10.1038/s41591-019-0633-x
Autor:
Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee, Nicolas Severe, Brody H. Foy, Fadi E. Pulous, Shuang Zhang, Konstantinos D. Kokkaliaris, Vanessa Frodermann, Gabriel Courties, Chongbo Yang, Yoshiko Iwamoto, Anders Steen Knudsen, Cameron S. McAlpine, Masahiro Yamazoe, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Karin Gustafsson, Diane Capen, Dennis Brown, John M. Higgins, David T. Scadden, Peter Libby, Filip K. Swirski, Kamila Naxerova, Matthias Nahrendorf
Publikováno v:
Nature Immunology. 23:1285-1285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b67f45ee8b2cec8db8404ff176e87e4b
https://doi.org/10.1038/s41590-022-01266-3
https://doi.org/10.1038/s41590-022-01266-3
Autor:
Ruslan I. Sadreyev, Konstantinos D. Kokkaliaris, Nicolas Severe, David B. Sykes, Fei Ji, Michael K. Mansour, Jefferson Seidl, David T. Scadden, Ani Papazian, Youmna Kfoury, Pavel Ivanov, Anthony Anselmo, Francois Mercier, Thomas Brouse, Michael Mazzola, Allison K. Scherer, Yasutoshi Akiyama, Borja Saez
Extracellular vesicles transfer complex biologic material between cells, whose role in in-vivo organismal physiology is poorly defined. Here, we demonstrate that osteoblastic cells in the bone marrow elaborate extracellular vesicles that are taken up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ed757f70bd780cc82aab8e44e25126
https://doi.org/10.1101/2021.04.13.439696
https://doi.org/10.1101/2021.04.13.439696
Autor:
Nikolas Barkas, Philip J. Saylor, David B. Sykes, Elizabeth W. Scadden, Shenglin Mei, Anna A. Igolkina, Thomas Brouse, Taghreed Hirz, Nicolas Severe, Youmna Kfoury, Ninib Baryawno, Bryan D. Choi, Karin Gustafsson, John H. Shin, David T. Scadden, Peter V. Kharchenko
Bone metastases are devastating complications of cancer. They are particularly common in prostate cancer, represent incurable disease and are refractory to immunotherapy. We sought to define distinct features of the bone marrow microenvironment by an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851a7e9b2d08f2fceeeb80e199941aea
https://doi.org/10.1101/2020.03.19.998658
https://doi.org/10.1101/2020.03.19.998658
Autor:
Ingunn Holen, Walter M Gregory, Nicolas Severe, Sandra S. McAllister, Jaclyn Sceneay, Ninib Baryawno, Marie-Therese Haider, Catherine Rhee, David T. Scadden, Molly J. DeCristo, Robert E. Coleman, Yuanbo Qin, Ana C. Garrido-Castro, John N. Hutchinson, Janet E. Brown, Jessalyn M. Ubellacker
Publikováno v:
Cancer Research. 78:5300-5314
The presence of disseminated tumor cells in breast cancer patient bone marrow aspirates predicts decreased recurrence-free survival. Although it is appreciated that physiologic, pathologic, and therapeutic conditions impact hematopoiesis, it remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf032230ae5256c442d85d28d7c9416
https://doi.org/10.1158/0008-5472.can-18-0548
https://doi.org/10.1158/0008-5472.can-18-0548