Výsledky vyhledávání - "Nicolas Sakkas"

Phosphine-Mediated Bioconjugation of the 3′-End of RNA

Autor: Pauline Poinot, Camélia Kitoun, Matthieu Fonvielle, Quentin Blancart Remaury, Manon Lefresne, Laura Iannazzo, Nicolas Sakkas, Fabiola Djago, Mélanie Etheve-Quelquejeu, Michel Arthur

Publikováno v: Organic Letters
Organic Letters, 2020, 22 (20), pp.8034-8038. ⟨10.1021/acs.orglett.0c02982⟩
Organic Letters, American Chemical Society, 2020, 22 (20), pp.8034-8038. ⟨10.1021/acs.orglett.0c02982⟩

International audience; Staudinger ligation is an attractive bio-orthogonal reaction that has been widely used to tag proteins, carbohydrates, and nucleic acids. Here, we explore the traceless variant of the Staudinger ligation for 3′-end modificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6486e170b4bb14d85ffe178376bd98
https://hal.science/hal-02996863

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Synthesis of lipid-carbohydrate-peptidyl-RNA conjugates to explore the limits imposed by the substrate specificity of cell wall enzymes on the acquisition of drug resistance

Autor: Michel Arthur, Tom Brown, Nicolas Sakkas, Ahmed Bouhss, Delphine Patin, Dominique Mengin-Lecreulx, Affaf El Sagheer, Coralie Hoareau, Matthieu Fonvielle, Laura Iannazzo, Mélanie Etheve-Quelquejeu

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (56), pp.14911-14915. ⟨10.1002/chem.201802360⟩
Chemistry-A European Journal, 2018, 24 (56), pp.14911-14915. ⟨10.1002/chem.201802360⟩

International audience; Conjugation of RNA with multiple partners to obtain mimics of complex biomolecules is limited by the identification of orthogonal reactions. Here, lipid-carbohydrate-peptidyl-RNA conjugates were obtained by post-functionalizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a61e985fea19de10ec136369ceae6b
https://hal.sorbonne-universite.fr/hal-01962025

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Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes

Autor: Tom Brown, Chloé Le Fournis, Matthieu Fonvielle, Nicolas Sakkas, Laura Iannazzo, Sébastien Cardon, Dominique Mengin-Lecreulx, Emmanuelle Braud, Delphine Patin, Mélanie Etheve-Quelquejeu, Michel Arthur, Afaf H. El-Sagheer

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55 (43), pp.13553-13557. ⟨10.1002/anie.201606843⟩
Angewandte Chemie (English Edition)
Angewandte Chemie (English Edition), John Wiley & Sons, 2016, 55 (43), pp.13553-13557. 〈10.1002/anie.201606843〉
Angewandte Chemie (English Edition), John Wiley & Sons, 2016, 55 (43), pp.13553-13557. ⟨10.1002/anie.201606843⟩
Angewandte Chemie International Edition, 2016, 55 (43), pp.13553-13557. ⟨10.1002/anie.201606843⟩

International audience; RNA functionalization is challenging due to the instability of RNA and the limited range of available enzymatic reactions. We developed a strategy based on solid phase synthesis and post-functionalization to introduce an elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43bab3d414a2907a7cd5f5547016d6a
https://hal.archives-ouvertes.fr/hal-01440830

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Synthesis of 3'-triazoyl-dinucleotides as precursors of stable Phe-tRNA(Phe) and Leu-tRNA(Leu) analogues

Autor: Mélanie Etheve-Quelquejeu, Emmanuelle Braud, Marco Santarem, Michel Arthur, Jean-Philippe Herbeuval, Nicolas Sakkas, Maryline Chemama, Matthieu Fonvielle, Guillaume Laisné

Publikováno v: Bioorganicmedicinal chemistry letters. 24(15)

We report here the synthesis of stable Phe-tRNA Phe and Leu-tRNA Leu analogues containing a 1,2,3-triazole ring instead of the ribose-amino acid ester bond. The 1,2,3-triazole ring is generated by dipolar cycloaddition of alkyne Phe and Leu analogues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6eb327b2dbd69e024a1e5dfa18b3ed
https://pubmed.ncbi.nlm.nih.gov/24986659

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