'One Ring to Bind Them All'—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles

Autor: Anton Granzhan, David Monchaud, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou

Publikováno v: Journal of Nucleic Acids, Vol 2010 (2010)

A collection of 26 polyammonium cyclophane-type macrocycles with a large structural diversity has been screened for G-quadruplex recognition. A two-step selection procedure based on the FRET-melting assay was carried out enabling identification of ma

Externí odkaz: https://doaj.org/article/8e5956d4aef54273a33fcbc5aeea05ee

Benchmark of four popular virtual screening programs: construction of the active/decoy dataset remains a major determinant of measured performance

Autor: Juan Martinez-Sanz, Ludovic Chaput, Nicolas Saettel, Liliane Mouawad

Publikováno v: Journal of Cheminformatics

Background In a structure-based virtual screening, the choice of the docking program is essential for the success of a hit identification. Benchmarks are meant to help in guiding this choice, especially when undertaken on a large variety of protein t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68017831e41944e737fcffcf4e176358
https://doi.org/10.1186/s13321-016-0167-x

N-phenyl-carbazole-based two-photon fluorescent probes: Strong sequence dependence of the duplex vs quadruplex selectivity

Autor: Blaise Dumat, Guillaume Bordeau, Céline Fiorini-Debuisschert, Fabrice Charra, Germain Metgé, Marie-Paule Teulade-Fichou, M. Bombled, Nicolas Saettel, Elodie Faurel-Paul, Florence Mahuteau-Betzer

Publikováno v: Biochimie. 93:1209-1218

Herein we report on the synthesis and DNA recognition properties of a series of three N-phenyl carbazole-based light-up probes initially designed for two-photon absorption. The vinylic derivatives (Cbz-2Py, Cbz-3Py) display strong fluorescence enhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a8a8cdf871bb296d7d9573cd8e0086
https://doi.org/10.1016/j.biochi.2011.05.035

3D Pharmacophore, hierarchical methods, and 5-HT4 receptor binding data

Autor: Ronan Bureau, François Dauphin, Thibault Varin, Jonathan Villain, Aurélien Lesnard, Sylvain Rault, Nicolas Saettel

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2008, 23 (5), pp.593-603. 〈10.1080/14756360802204748〉
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2008, 23 (5), pp.593-603. ⟨10.1080/14756360802204748⟩

International audience; 5-Hydroxytryptamine subtype-4 (5-HT(4)) receptors have stimulated considerable interest amongst scientists and clinicians owing to their importance in neurophysiology and potential as therapeutic targets. A comparative analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d231efcddaddfb0b0f84b8519b3aba94
https://doi.org/10.1080/14756360802204748

Influence of the oxazole ring connection on the fluorescence of oxazoyl-triphenylamine biphotonic DNA probes

Autor: Pauline Fornarelli, Germain Metgé, Nicolas Saettel, Fabrice Charra, Marie-Paule Teulade-Fichou, Florence Mahuteau-Betzer, Céline Fiorini-Debuisschert, Blaise Dumat, Elodie Faurel-Paul

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2015, 14 (1), pp.358-370. ⟨10.1039/C5OB02225H⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2015, 14 (1), pp.358-370. ⟨10.1039/C5OB02225H⟩

International audience; On the basis of our previous work on DNA fluorophores derived from vinylpyridinium-triphenylamine, we explored the structure space around the electron-rich triphenylamine (TP) core by changing the vinyl bond to an oxazole ring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb5d7ce3771506e03daf172d857eb07
https://hal-cea.archives-ouvertes.fr/cea-01483796