Zobrazeno 1 - 3
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pro vyhledávání: '"Nicolas S Gonzalez-Foutel"'
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Ahmad Malik, Nicolas S. Gonzalez-Foutel, Carmen Florencia Suarez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N. Al-Zahrani, Zhen Yuan Lin, Ricky Tsai, Varda Rotter, Patricia Ashton-Prolla, Lucia B. Chemes, Jason Moffat, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Tumour suppressor p53 (TP53) is the most frequently mutated gene in cancer. Several hotspot p53 mutants not only lose tumour suppressive capabilities, but also function in a dominant-negative manner, suppressing canonical wild-type p53 function. Furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b71a8a4725ba188f570cfb1571bcd4
https://doi.org/10.1101/2022.03.13.483372
https://doi.org/10.1101/2022.03.13.483372
Autor:
Gary W. Daughdrill, Wade Borcherds, Alex S. Holehouse, Ignacio E. Sánchez, Clara Blanes-Mira, Alejandro Estaña, Susana Barrera-Vilarmau, Amin Sagar, Gregorio Fernández-Ballester, Juan Cortés, Pau Bernadó, Rohit V. Pappu, Amélie Barozet, Juliana Glavina, Gonzalo de Prat-Gay, Lucía B. Chemes, Nicolas S. Gonzalez-Foutel
Many disordered proteins conserve essential functions in the face of extensive sequence variation. This makes it challenging to identify the forces responsible for functional selection. Viruses are robust model systems to investigate functional selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74353c0c8cc7af904aedc731bc0f6b34
https://doi.org/10.1101/2021.05.14.444182
https://doi.org/10.1101/2021.05.14.444182