Výsledky vyhledávání - "Nicolas Quizon"

Cascading YOLO: automated malaria parasite detection for Plasmodium vivax in thin blood smears

Autor: Stefan Jaeger, Feng Yang, Nicolas Quizon, Richard J. Maude, Kamolrat Silamut, Hang Yu, Sameer Antani

Publikováno v: Medical Imaging 2020: Computer-Aided Diagnosis.

Malaria, caused by Plasmodium parasites, continues to be a major burden on global health. Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax) pose the greatest health threat among the five malaria species. Microscopy examination is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef8ae61addb74bb74c4ee5ea7ec96fb0
https://doi.org/10.1117/12.2549701

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Dropped head congenital muscular dystrophy caused by de novo mutations in LMNA

Autor: Semra Hız Kurul, Pakize Karaoglu, Matthias Pergande, Lena Willkomm, Ayşe İpek Polat, Duygu Selcen, Haicui Wang, Erdener Özer, Uluç Yiş, Ayca Ersen, Raul Heredia, Nicolas Quizon, Sebahattin Cirak

Publikováno v: Brain and Development. 39:361-364

Background: Dropped head syndrome is an easily recognizable clinical presentation of Laurin A/C-related congenital muscular dystrophy. Patients usually present in the first year of life with profound neck muscle weakness, dropped head, and elevated s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cfbb471145f2401aa6c3c697670334
https://doi.org/10.1016/j.braindev.2016.11.002

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Intrinsic properties of human germinal center B cells set antigen affinity thresholds

Autor: Haewon Sohn, Katelyn M. Spillane, Pavel Tolar, Joseph Brzostowski, Avva Saniee, Susan K. Pierce, Kihyuck Kwak, Prasida Holla, Nicolas Quizon, Hengyi Xie, Jinghua Lu, Javier Manzella-Lapeira, Chenguang Xu

Publikováno v: Kwak, K, Quizon, N, Sohn, H, Saniee, A, Manzella-Lapeira, J, Holla, P, Brzostowski, J, Xie, H, Xu, C, Spillane, K M, Tolar, P & Pierce, S K 2018, ' Intrinsic properties of human germinal center B cells set antigen affinity thresholds ', Science Immunology, vol. 3, no. 29, pp. eaau6598 . https://doi.org/10.1126/sciimmunol.aau6598

Protective antibody responses to vaccination or infection depend on affinity maturation, a process by which high-affinity germinal center (GC) B cells are selected on the basis of their ability to bind, gather, and present antigen to T follicular hel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cdc0ea0bd63493eb01fbc312548da1
https://kclpure.kcl.ac.uk/ws/files/103471808/Intrinsic_properties_of_human_KWACK_Published30November2018_SUPP.pdf

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Extraction and intracellular trafficking of membrane associated antigen distinguishes human germinal center B cells from naïve B cells and memory B cells

Autor: Kihyuck Kwak, Avva Saniee, Nicolas Quizon, Haewon Sohn, Susan Pierce

Publikováno v: The Journal of Immunology. 200:99.25-99.25

Protective antibody responses to vaccination or infection in humans depend on the competitive selection of high-affinity germinal-center (GC) B cells into the long-lived memory B cell compartment. Selection is determined in large part by the ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54340add761e716b2adabe32c2610c16
https://doi.org/10.4049/jimmunol.200.supp.99.25

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Bioengineered organoid models of human germinal centers

Autor: Nicolas Quizon, Kihyuck Kwak, Shivem Shah, Ankur Singh, Susan Pierce

Publikováno v: The Journal of Immunology. 200:120.14-120.14

B cells undergo affinity maturation to T cell-dependent antigens within specialized microenvironments in secondary lymphoid organs termed germinal centers (GCs) resulting in the selective proliferation and differentiation of high-affinity B cells. Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b348ea22f73be8159f4da587b764d028
https://doi.org/10.4049/jimmunol.200.supp.120.14

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Human germinal center B cells are intrinsically able to discriminate antigen affinity and with T cell help express plasma cell transcription factors

Autor: Avva Saniee, Kihyuck Kwak, Nicolas Quizon, Haewon Sohn, Javier Manzella-Lapeira, Prasida Holla, Jinghua Lu, HengYi Xie, Chenguang Xu, Katelyn Spillane, Pavel Tolar, Susan K. Pierce

Publikováno v: The Journal of Immunology. 200:107.17-107.17

The selection of GC B cells that express high affinity B cell receptors (BCRs) is driven by the ability of B cells to both signal through the BCR and to extract antigen and present it to follicular helper T cells (T FH cells). Using anti-kappa antibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c61c83ed34e0047cead77566f4304d5c
https://doi.org/10.4049/jimmunol.200.supp.107.17

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Human germinal center B cells are intrinsically distinct from naive B cells

Autor: Nicolas Quizon, Kihyuck Kwak, Haewon Sohn, Susan K. Pierce

Publikováno v: The Journal of Immunology. 198:52.4-52.4

In germinal centers (GCs) B cells undergo cycles of proliferation and somatic hyper mutation followed by affinity discrimination. Selection of GC B cells expressing high affinity B cell receptors (BCRs) is driven by the ability of B cells to signal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82f4d34a2898f67d90133bf51f22b5d6
https://doi.org/10.4049/jimmunol.198.supp.52.4

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