Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity

Autor: Manuel Vlach, Nicolas Quesnot, Hélène Dubois-Pot-Schneider, Catherine Ribault, Yann Verres, Kilian Petitjean, Claudine Rauch, Fabrice Morel, Marie-Anne Robin, Anne Corlu, Pascal Loyer

Publikováno v: Sensors, Vol 19, Iss 10, p 2245 (2019)

Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics. In

Externí odkaz: https://doaj.org/article/798c9c749f6646ef8bc3f35efb143899

Weight of Evidence and Human Relevance Evaluation of the Benfluralin Mode of Action in Rats (Part II): Thyroid carcinogenesis

Autor: Christian Strupp, Nicolas Quesnot, Céline Weber-Parmentier, Lysiane Richert, Werner H. Bomann, Pramila Singh

Publikováno v: Regulatory toxicology and pharmacology : RTP. 117

Benfluralin is an herbicide of the dinitroaniline class used to control grasses and weeds. In a 2 year dietary study in rats, benfluralin increased incidences of thyroid follicular adenoma and carcinoma at high dietary concentrations (≥2500 ppm). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ca8cbe677f2ab181a7653d673d6187
https://pubmed.ncbi.nlm.nih.gov/32798613

Diallyl disulfide prevents cigarette smoke-induced emphysema in mice

Autor: Manuella Lanzetti, Helber da Maia Valença, Nicolas Quesnot, Cyntia Pecli e Silva, Lycia de Brito-Gitirana, Francisca de Fátima dos Anjos, Isabella Cattani-Cavalieri, Samuel Santos Valença, Aline de Oliveira Pontes Cardoso

Publikováno v: Pulmonary Pharmacology & Therapeutics. 69:102053

Introduction Cigarette smoke (CS) is the main risk factor for the development of chronic obstructive pulmonary disease (COPD) and pulmonary emphysema . The use of antioxidants has emerged as a potential therapeutic strategy to treat airway inflammati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cbb39ce9ccf98803ffc0cdb94e6e93
https://doi.org/10.1016/j.pupt.2021.102053

Atorvastatin dose-dependently promotes mouse lung repair after emphysema induced by elastase

Autor: Isabella Cattani-Cavalieri, Marina Valente Barroso, Lycia de Brito Gitirana, Samuel Santos Valença, Adriana Correa Melo, Nicolas Quesnot, Manuella Lanzetti

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 102

Emphysema results in a proteinase – antiproteinase imbalance, inflammation and oxidative stress. Our objective was to investigate whether atorvastatin could repair mouse lungs after elastase-induced emphysema. Vehicle (50 μL) or porcine pancreatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8567ce66b426558cf1c9c7385f8cf8a8
https://pubmed.ncbi.nlm.nih.gov/29554594

Efficient transfection of Xenobiotic Responsive Element-biosensor plasmid using diether lipid and phosphatidylcholine liposomes in differentiated HepaRG cells

Autor: Nicolas Quesnot, Jelena Jeftić, Nicolas Ripoche, Maxime Demazeau, Fabrice Morel, Fabienne Gauffre, Thierry Benvegnu, Pascal Loyer, Claudine Rauch

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2017, 524 (1-2), pp.268-278. ⟨10.1016/j.ijpharm.2017.03.080⟩
International Journal of Pharmaceutics, 2017, 524 (1-2), pp.268-278. ⟨10.1016/j.ijpharm.2017.03.080⟩

International audience; In this study, we evaluated cationic liposomes prepared from diether-NH2 and egg phosphatidylcholine (EPC) for in vitro gene delivery. The impact of the lipid composition, i.e. the EPC and Diether-NH2 molar ratio, on in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee258a14ed83e9bc3dca3155890970e2
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01518045/document