Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

Autor: Marie-Pierre Péli-Gulli, Alessandro Sardu, Nicolas Panchaud, Serena Raucci, Claudio De Virgilio

Publikováno v: Cell Reports, Vol 13, Iss 1, Pp 1-7 (2015)

Rag GTPases assemble into heterodimeric complexes consisting of RagA or RagB and RagC or RagD in higher eukaryotes, or Gtr1 and Gtr2 in yeast, to relay amino acid signals toward the growth-regulating target of rapamycin complex 1 (TORC1). The TORC1-s

Externí odkaz: https://doaj.org/article/1da506b6d4aa4a25a849b4a930e5e566

Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults:A Randomized Clinical Trial

Autor: Jens Praestgaard, Liang Kung Chen, Hidenori Arai, Olivier Petricoul, Budhaditya Goswami, Dimitris Papanicolaou, John Vissing, Yoon Sok Chung, Chris Recknor, Estelle Lach-Trifilieff, Jun Hashimoto, Laura A. Coleman, Nicolas Panchaud, Ram R. Miller, Lee Anne Filosa, Didier Laurent, Robert G. Perry, Sarah Hemsley, Charles M. Fogarty, Ola Bunte, Ronenn Roubenoff, Daniel Rooks, Therese Swan, Elisa Garcia Garayoa

Publikováno v: Rooks, D, Swan, T, Goswami, B, Filosa, L A, Bunte, O, Panchaud, N, Coleman, L A, Miller, R R, Garcia Garayoa, E, Praestgaard, J, Perry, R G, Recknor, C, Fogarty, C M, Arai, H, Chen, L K, Hashimoto, J, Chung, Y S, Vissing, J, Laurent, D, Petricoul, O, Hemsley, S, Lach-Trifilieff, E, Papanicolaou, D A & Roubenoff, R 2020, ' Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults : A Randomized Clinical Trial ', JAMA Network Open, vol. 3, no. 10, e2020836 . https://doi.org/10.1001/jamanetworkopen.2020.20836
JAMA Netw Open

Importance: The potential benefit of novel skeletal muscle anabolic agents to improve physical function in people with sarcopenia and other muscle wasting diseases is unknown. Objective: To confirm the safety and efficacy of bimagrumab plus the new s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2548e2635b4203a261b60319a8a0f71d
https://curis.ku.dk/ws/files/253352215/Bimagrumab_vs_Optimized_Standard_of_Care_for_Treatment_of_Sarcopenia.pdf

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

Autor: Claudio De Virgilio, Rong Wang, Nicolas Panchaud, Katie Powis, Tianlong Zhang, Jianping Ding

Publikováno v: Cell Research

The target of rapamycin complex 1 (TORC1) integrates various hormonal and nutrient signals to regulate cell growth, proliferation, and differentiation. Amino acid-dependent activation of TORC1 is mediated via the yeast EGO complex (EGOC) consisting o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1d9999031ea209672cddaf12a71b06
https://doi.org/10.1038/cr.2015.86

Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae

Autor: Nicolas Panchaud, Joerg Urban, Manuele Piccolis, Claudio De Virgilio, Shigeyuki Kawai, Robbie Loewith

Publikováno v: Eukaryotic cell
Eukaryotic Cell, Vol. 10, No 10 (2011) pp. 1367-9
Eukaryotic Cell

TORC1-dependent phosphorylation of Saccharomyces cerevisiae Sch9 was dramatically reduced upon exposure to a protonophore or in respiration-incompetent ρ 0 cells but not in respiration-incompetent pet mutants, providing important insight into the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3278e2cbc5fd0aacf1475d9db6bad12

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

Autor: Larry A. Sklar, Robbie Loewith, Margaret Werner-Washburne, Tuanli Yao, J. Jacob Strouse, Nicolas Panchaud, Chris Allen, Oleg Ursu, Marie-Pierre Péli-Gulli, Jun Chen, Jeffrey Aubé, Mark B. Carter, Susan M. Young, Huining Kang, Bruce S. Edwards, Jennifer E. Golden, Anna Waller, Blake R. Peterson, Cristian Bologa, Andrew Seeber, Claudio De Virgilio, Terry D. Foutz

Publikováno v: ACS Chemical Biology, Vol. 7, No 4 (2012) pp. 715-22
ACS chemical biology
ACS Chemical Biology

TOR (target of rapamycin) is a serine/threonine kinase, evolutionarily conserved from yeast to human, which functions as a fundamental controller of cell growth. The moderate clinical benefit of rapamycin in mTOR-based therapy of many cancers favors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33ab282d04033750ec895863a0d7781
https://archive-ouverte.unige.ch/unige:26555