Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Nicolas P Smith"'
Autor:
Yolanda R Hill, Nick Child, Ben Hanson, Mikael Wallman, Ruben Coronel, Gernot Plank, Christopher A Rinaldi, Jaswinder Gill, Nicolas P Smith, Peter Taggart, Martin J Bishop
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149342 (2016)
Exit sites associated with scar-related reentrant arrhythmias represent important targets for catheter ablation therapy. However, their accurate location in a safe and robust manner remains a significant clinical challenge. We recently proposed a nov
Externí odkaz:
https://doaj.org/article/7aec44b286a94858bc24a7ca932feda6
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 4, p e1002459 (2012)
Polymorphisms identified in genome-wide association studies of human traits rarely explain more than a small proportion of the heritable variation, and improving this situation within the current paradigm appears daunting. Given a well-validated dyna
Externí odkaz:
https://doaj.org/article/041f5bd4803a48ea816d2ec46ada8776
Autor:
Steven A Niederer, Nicolas P Smith
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 4, p e1000371 (2009)
We have developed a multi-scale biophysical electromechanics model of the rat left ventricle at room temperature. This model has been applied to investigate the relative roles of cellular scale length dependent regulators of tension generation on the
Externí odkaz:
https://doaj.org/article/101f02bb36064bc3976cd2c48aff2fb6
Autor:
Krish Chaudhuri, Alexander Pletzer, Steve W. F. R. Waqanivavalagi, Paget Milsom, Nicolas P. Smith
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
ObjectivesFlow competition between coronary artery bypass grafts (CABG) and native coronary arteries is a significant problem affecting arterial graft patency. The objectives of this study were to compare the predictive hemodynamic flow resulting fro
Externí odkaz:
https://doaj.org/article/487a80e435da453da2d018bd888a93a4
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiac surgeons face a significant degree of uncertainty when deciding upon coronary artery bypass graft configurations for patients with coronary artery disease. This leads to significant variation in preferred configuration between different surge
Externí odkaz:
https://doaj.org/article/967ef357315e442793d50630580fb6b8
Autor:
David Benoist, David Baddeley, Nicolas P. Smith, Richard D. Walton, Gregory B. Sands, Bruce H. Smaill, Olivier Bernus, Igor R. Efimov, Mark L. Trew, Jesse L. Ashton
Publikováno v:
Progress in Biophysics and Molecular Biology. 168:18-32
Recent developments in clearing and microscopy enable 3D imaging with cellular resolution up to the whole organ level. These methods have been used extensively in neurobiology, but their uptake in other fields has been much more limited. Application
Publikováno v:
Scientific poster presentations.
Autor:
Ivar Sjaastad, Jan Magnus Aronsen, Steven A. Niederer, Sara Gattoni, William E. Louch, Åsmund T. Røe, Nicolas P. Smith
Publikováno v:
The Journal of Physiology. 595:3867-3889
Key points At the cellular level cardiac hypertrophy causes remodelling, leading to changes in ionic channel, pump and exchanger densities and kinetics. Previous studies have focused on quantifying changes in channels, pumps and exchangers without qu
Autor:
Hiroki Takahashi, Alex Wilson, Andrew Riley-Watson, Fedja Oručević, Nicolas Seymour-Smith, Matthias Keller, Wolfgang Lange
Publikováno v:
New Journal of Physics, Vol 15, Iss 5, p 053011 (2013)
We report on a novel single-photon source using a single calcium ion trapped between the end facets of two optical fibers. The optical fibers act as photonic channels, and in addition their metallic jackets provide a trapping electric field for the i
Externí odkaz:
https://doaj.org/article/796e2f2062e84ffa94e90c6555673bf6
Autor:
William E. Louch, Åsmund T. Røe, Steven A. Niederer, Michael Frisk, Nicolas P. Smith, Sara Gattoni
Publikováno v:
The Journal of Physiology. 594:4193-4224
KEY POINTS In the majority of species, including humans, increased heart rate increases cardiac contractility. This change is known as the force-frequency response (FFR). The majority of mammals have a positive force-frequency relationship (FFR). In