Phenotypic and Functional Characterization of Herpes Simplex Virus Glycoprotein B Epitope-Specific Effector and Memory CD8+ T Cells from Symptomatic and Asymptomatic Individuals with Ocular Herpes

Autor: Jasmine Kuang, Lei Huang, Thanh T. Pham, Steven L. Wechsler, Hawa Vahed, Sumit Garg, Nicolas N. Ong, Ruchi Srivastava, Anthony B. Nesburn, Lbachir BenMohamed, Patricia P. Lopes, Charlie Hewett, Doran Spencer, Vanessa M. Scarfone, Arif A. Khan, Daniel Fremgen

Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8 + T cells protect mice from herpes infection and disease. However, whether and which HSV-1 gB-specific CD8 + T cells play a key role in the “natural” protection seen in HSV-1-seropos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff4e19506bfc4cade778256bdbd15a8
https://europepmc.org/articles/PMC4403403/

Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes.

Autor: Khan AA; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Srivastava R; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Spencer D; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Garg S; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Fremgen D; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Vahed H; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Lopes PP; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Pham TT; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Hewett C; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Kuang J; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Ong N; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Huang L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Scarfone VM; Stem Cell Research Center, University of California, Irvine, Irvine, California, USA., Nesburn AB; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA., Wechsler SL; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California, Irvine, School of Medicine, Irvine, California, USA Department of Microbiology and Molecular Genetics, University of California, Irvine, School of Medicine, Irvine, California, USA Center for Virus Research, University of California, Irvine, Irvine, California, USA., BenMohamed L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA Department of Molecular Biology & Biochemistry, University of California, Irvine, School of Medicine, Irvine, California, USA Institute for Immunology, University of California, Irvine, School of Medicine, Irvine, California, USA Lbenmoha@uci.edu.

Publikováno v: Journal of virology [J Virol] 2015 Apr; Vol. 89 (7), pp. 3776-92. Date of Electronic Publication: 2015 Jan 21.