Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nicolas Mercado"'
Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation
Autor:
Yuta Kono, Thomas Colley, Masako To, Andriana I. Papaioannou, Nicolas Mercado, Jonathan R. Baker, Yasuo To, Shinji Abe, Kosuke Haruki, Kazuhiro Ito, Peter J. Barnes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the consequences of this defect have not been fully elucidated, especially in macrophages. Dysfunctional alveolar macrophages play an important role in chron
Externí odkaz:
https://doaj.org/article/53ee665d1b754109b38eb255b8f98a81
Autor:
Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 11, Pp 688-705 (2019)
Abstract Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD
Externí odkaz:
https://doaj.org/article/cdb8ba9ea62e4c0dade8fba235ccd388
Autor:
Nicolas Mercado, Gabi Schutzius, Christian Kolter, David Estoppey, Sebastian Bergling, Guglielmo Roma, Caroline Gubser Keller, Florian Nigsch, Adrian Salathe, Remi Terranova, John Reece-Hoyes, John Alford, Carsten Russ, Judith Knehr, Dominic Hoepfner, Alexandra Aebi, Heinz Ruffner, Tanner C. Beck, Sajjeev Jagannathan, Calla M. Olson, Hadley E. Sheppard, Selma Z. Elsarrag, Tewis Bouwmeester, Mathias Frederiksen, Felix Lohmann, Charles Y. Lin, Susan Kirkland
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a
Externí odkaz:
https://doaj.org/article/0f22070deb8646359f9b585b7f128992
Autor:
Nicolas Mercado, Yasuo Kizawa, Keitaro Ueda, Yeping Xiong, Genki Kimura, Audric Moses, Jonathan M Curtis, Kazuhiro Ito, Peter J Barnes
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88168 (2014)
BackgroundAnti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative an
Externí odkaz:
https://doaj.org/article/ee0a259b16ce4562b54b96c98ae158ca
Autor:
Nicolas Mercado, Amir Hakim, Yoshiki Kobayashi, Sally Meah, Omar S Usmani, Kian Fan Chung, Peter J Barnes, Kazuhiro Ito
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41582 (2012)
Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be involved because of a very hetero
Externí odkaz:
https://doaj.org/article/8a35bc033b354a85aeeac8b3ec45649b
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27627 (2011)
BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated. The object of this study is to inv
Externí odkaz:
https://doaj.org/article/ab5a057f4aa74c1d80efaf18c0704882
Autor:
Carsten Russ, Adrian Salathe, Charles Y. Lin, John Alford, Mathias Frederiksen, Caroline Gubser Keller, Gabi Schutzius, Sajjeev Jagannathan, Sebastian Bergling, Dominic Hoepfner, Heinz Ruffner, Nicolas Mercado, Judith Knehr, Alexandra Aebi, John S. Reece-Hoyes, Guglielmo Roma, David Estoppey, Remi Terranova, Hadley E. Sheppard, Calla M. Olson, Tewis Bouwmeester, Tanner C. Beck, Susan Kirkland, Florian Nigsch, Christian Kolter, Felix Lohmann, Selma Z. Elsarrag
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications
Nature Communications
Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting extrinsic and intrinsic regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c9ef08e8616e1ba4a2ab8d68197bb3
http://link.springer.com/article/10.1038/s41467-019-12559-x
http://link.springer.com/article/10.1038/s41467-019-12559-x
Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation
Autor:
Shinji Abe, Kazuhiro Ito, Kosuke Haruki, Peter J. Barnes, Yuta Kono, Masako To, Andriana I. Papaioannou, Thomas Colley, Jonathan R. Baker, Nicolas Mercado, Yasuo To
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the consequences of this defect have not been fully elucidated, especially in macrophages. Dysfunctional alveolar macrophages play an important role in chronic obstru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be729ee932baa2b61245c431eedda33
https://pubmed.ncbi.nlm.nih.gov/33432024
https://pubmed.ncbi.nlm.nih.gov/33432024
Autor:
Lukas Roth, Laura Israel, Stefanie Ginster, Nicolas Mercado, Frédéric Bornancin, Jean Francois Goetschy, Frank Kolbinger, Adeline Unterreiner, Antje Huppertz, Hans-Guenter Zerwes, Maureen Bardet, Anita Schlierf
Publikováno v:
Journal of Investigative Dermatology. 138:2075-2079
The paracaspase MALT1 (Mucosa associated lymphoid tissue lymphoma translocation protein 1) controls signaling downstream of several cell surface receptors, such as C-type lectin receptors on myeloid cells and antigen receptors on lymphocytes. Upon re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b090dc6916341204015d0a9e73fe61d4
https://doi.org/10.1016/j.jid.2018.03.1503
https://doi.org/10.1016/j.jid.2018.03.1503
Publikováno v:
Thorax. 70:482-489
The rise in life expectancy worldwide has been accompanied by an increased incidence of age-related diseases, representing an enormous burden on healthcare services and society. All vital organs lose function with age, and this is well described in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f940f715aef75a5f315a6466419e4faf
https://doi.org/10.1136/thoraxjnl-2014-206084
https://doi.org/10.1136/thoraxjnl-2014-206084