Výsledky vyhledávání - "Nicolas Melis"

Akademický článek

The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles

Autor: Michel Tauc, Marc Cougnon, Romain Carcy, Nicolas Melis, Thierry Hauet, Luc Pellerin, Nicolas Blondeau, Didier F. Pisani

Publikováno v: Cell & Bioscience, Vol 11, Iss 1, Pp 1-23 (2021)

Abstract Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers in which the isoform A2 is mainly expressed.

Externí odkaz: https://doaj.org/article/b37c878fff754435ae08d83cd4573bc1

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Akademický článek

Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Autor: Marc Cougnon, Romain Carcy, Nicolas Melis, Isabelle Rubera, Christophe Duranton, Karine Dumas, Jean-François Tanti, Catherine Pons, Nicolas Soubeiran, Marina Shkreli, Thierry Hauet, Luc Pellerin, Sébastien Giraud, Nicolas Blondeau, Michel Tauc, Didier F. Pisani

Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)

Abstract Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia. The highlighted mechanism involves a metabolic swit

Externí odkaz: https://doaj.org/article/1c2ead5a19d749b38f91c58c3d62652c

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Akademický článek

Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress

Autor: Nicolas Melis, Isabelle Rubera, Sebastien Giraud, Marc Cougnon, Christophe Duranton, Mallorie Poet, Gisèle Jarretou, Raphaël Thuillier, Laurent Counillon, Thierry Hauet, Luc Pellerin, Michel Tauc, Didier F. Pisani

Publikováno v: Cells, Vol 12, Iss 3, p 409 (2023)

Through kidney transplantation, ischemia/reperfusion is known to induce tissular injury due to cell energy shortage, oxidative stress, and endoplasmic reticulum (ER) stress. ER stress stems from an accumulation of unfolded or misfolded proteins in th

Externí odkaz: https://doaj.org/article/05f32dd3ce7f408ab5c5f61bf0693e37

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Akademický článek

Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7

Autor: Ana Dios-Esponera, Nicolas Melis, Bhagawat C. Subramanian, Roberto Weigert, Lawrence E. Samelson

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-st

Externí odkaz: https://doaj.org/article/8153e5895b47424b8d23e08bf4895a2d

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Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing through Transforming Growth Factor-β/Smad3 Signaling

Autor: Christina H. Stuelten, Nicolas Melis, Bhagawat Subramanian, Yi Tang, Megan Kimicata, John P. Fisher, Roberto Weigert, Ying E. Zhang

Publikováno v: The American Journal of Pathology. 192:1699-1711

Wound healing is a highly conserved process that restores the integrity and functionality of injured tissues. Transforming growth factor (TGF)-β is a master regulator of wound healing, whose signaling is attenuated by the E3 ubiquitin ligase Smurf2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587bf920c8daa787029ea67b2730aae4
https://doi.org/10.1016/j.ajpath.2022.08.002

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Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions

Autor: Roberto Weigert, Desu Chen, Bhagawat Subramanian, Nicolas Melis

Publikováno v: Journal of visualized experiments : JoVE. (183)

The study of immune cell recruitment and function in tissues has been a very active field over the last two decades. Neutrophils are among the first immune cells to reach the site of inflammation and to participate in the innate immune response durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa9060450b270b17b0b5a499451b331
https://pubmed.ncbi.nlm.nih.gov/35635466

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Akt Inhibition as Preconditioning Treatment to Protect Kidney Cells against Anoxia

Autor: Nicolas Melis, Romain Carcy, Isabelle Rubera, Marc Cougnon, Christophe Duranton, Michel Tauc, Didier F. Pisani

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2022, 23 (1), pp.152. ⟨10.3390/ijms23010152⟩
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 152
International Journal of Molecular Sciences, Vol 23, Iss 152, p 152 (2022)

International audience; Lesions issued from the ischemia/reperfusion (I/R) stress are a major challenge in human pathophysiology. Of human organs, the kidney is highly sensitive to I/R because of its high oxygen demand and poor regenerative capacity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f4a85fa1afee38eeb662ddbafe2893
http://europepmc.org/articles/PMC8745656

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Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling

Autor: Jonathan D. Ashwell, Debjani Dutta, Matthias M Gaida, Roberto Weigert, Shizuka Otsuka, Nicolas Melis

Publikováno v: J Clin Invest

Inhibitors of calcineurin phosphatase activity (CNIs) such as cyclosporin A (CsA) are widely used to treat tissue transplant rejection and acute graft-versus-host disease (aGVHD), for which inhibition of gene expression dependent on nuclear factor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b86579d9d1b58a7b195ec97beba40a7
https://doi.org/10.1172/jci147683

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Emerging therapeutic strategies for transplantation-induced acute kidney injury: protecting the organelles and the vascular bed

Autor: Jonatan Barrera-Chimal, Jean-Pierre Richer, Clara Steichen, Frederic Jaisser, Lionel Badet, Yse Sauvageon, Sébastien Giraud, Michel Tauc, Thierry Hauet, Thomas Pelé, Raphael Thuillier, Jacques Kaminski, Nicolas Melis

Publikováno v: Expert Opinion on Therapeutic Targets
Expert Opinion on Therapeutic Targets, Taylor & Francis, 2019, 23 (6), pp.495-509. ⟨10.1080/14728222.2019.1609451⟩
Expert Opinion on Therapeutic Targets, 2019, 23 (6), pp.495-509. ⟨10.1080/14728222.2019.1609451⟩

International audience; Introduction: Renal ischemia-reperfusion injury (IRI) is a significant clinical challenge faced by clinicians in a broad variety of clinical settings such as perioperative and intensive care. Renal IRI induced acute kidney inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179b358af21a0d1f4caf9ad56e00676
https://doi.org/10.1080/14728222.2019.1609451

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