Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nicolas Leupin"'
Autor:
Stefan Knop, Monika Szarejko, Norbert Grząśko, Sara Bringhen, Karolin Trautmann‐Grill, Artur Jurczyszyn, Angelo Vacca, Cyrus Khandanpour, Barbara Gamberi, Ludek Pour, Katrine F. Iversen, Michael T. Stumpp, Cosima Suter, Keith M. Dawson, Christof Zitt, Philippe Legenne, Vaia Stavropoulou, Martin F. Fey, Nicolas Leupin, Hartmut Goldschmidt
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 940-950 (2024)
Abstract MP0250 is a designed ankyrin repeat protein that specifically inhibits both vascular endothelial growth factor A (VEGF‐A) and hepatocyte growth factor (HGF), aiming at potentiating cancer therapy by disrupting the tumour microenvironment.
Externí odkaz:
https://doaj.org/article/d9320941c5f7443ea0d680430869e3d7
Autor:
Philippe Aftimos, Christian Rolfo, Sylvie Rottey, Philippe Barthélémy, Christophe Borg, Keunchil Park, Do-Youn Oh, Sang-We Kim, Natalie De Jonge, Valérie Hanssens, Karen Zwanenpoel, Carla Molthoff, Daniëlle Vugts, Torsten Dreier, Peter Verheesen, Guus A.M.S. van Dongen, Julie Jacobs, Luc Van Rompaey, Anna Hultberg, Paolo Michieli, Patrick Pauwels, Samson Fung, Alain Thibault, Hans de Haard, Nicolas Leupin, Ahmad Awada
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 665 (2021)
Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase
Externí odkaz:
https://doaj.org/article/f221f0cc086e421e96736936b19db3e0
Autor:
Meletios A. Dimopoulos, Matthew C. Cheung, Murielle Roussel, Ting Liu, Barbara Gamberi, Brigitte Kolb, H. Guenter Derigs, HyeonSeok Eom, Karim Belhadj, Pascal Lenain, Richard Van der Jagt, Sophie Rigaudeau, Mamoun Dib, Rachel Hall, Henry Jardel, Arnaud Jaccard, Axel Tosikyan, Lionel Karlin, William Bensinger, Rik Schots, Nicolas Leupin, Guang Chen, Jennifer Marek, Annette Ervin-Haynes, Thierry Facon
Publikováno v:
Haematologica, Vol 101, Iss 3 (2016)
Renal impairment is associated with poor prognosis in myeloma. This analysis of the pivotal phase 3 FIRST trial examined the impact of renally adapted dosing of lenalidomide and dexamethasone on outcomes of patients with different degrees of renal im
Externí odkaz:
https://doaj.org/article/c7d7ee8abeb3409b82ff48e5ea23ff7d
Autor:
Ahmad Awada, Nicolas Leupin, Alain Thibault, Marc Peeters, Vincent Ribrag, Hans de Haard, Domenica Gandini, Anna Hultberg, Karen Silence, Jean-Marie Michot, Luc Van Rompaey, Torsten Dreier, Mahan Moshir, Jean-Charles Soria, Marie Maerevoet, Dominique Bron, Fritz Offner, Sylvie Rottey, Christian Rolfo, Philippe Aftimos
Purpose: The purpose of this study was to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor efficacy of ARGX-110, a glyco-engineered monoclonal antibody, targeting CD70, in patients with CD70 expressing advanced malignanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f67c8aed5e69084842277494b50f36b
https://doi.org/10.1158/1078-0432.c.6527006.v1
https://doi.org/10.1158/1078-0432.c.6527006.v1
Autor:
Ahmad Awada, Nicolas Leupin, Alain Thibault, Marc Peeters, Vincent Ribrag, Hans de Haard, Domenica Gandini, Anna Hultberg, Karen Silence, Jean-Marie Michot, Luc Van Rompaey, Torsten Dreier, Mahan Moshir, Jean-Charles Soria, Marie Maerevoet, Dominique Bron, Fritz Offner, Sylvie Rottey, Christian Rolfo, Philippe Aftimos
More details about inclusion and exclusion criteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4ba8d81175c304fee0f68912d285fb
https://doi.org/10.1158/1078-0432.22468604
https://doi.org/10.1158/1078-0432.22468604
Autor:
Stefanie Fischer, Thorsten O. Götze, Aurelius Omlin, Richard D. Baird, Keith M. Dawson, Christof Zitt, Zita Arany, Gaby Tresch, Ulrike Fiedler, Simone Jeger, Samson Fung, Philippe Legenne, Nicolas Leupin, Andreas Schneeweiss, Carlo Fremd
Publikováno v:
JCO precision oncology. 6
The human epidermal growth factor receptor 2 (HER2, ERBB2) is amplified or overexpressed in approximately 20% of breast cancers. HER2 amplification results in increased homodimerization and HER3 heterodimerization, with HER2/HER3 heterodimers promoti
Autor:
Matteo Bianchi, Christian Reichen, Stefanie Fischer, Yvonne Grübler, Aline Eggenschwiler, Rajlakshmi Marpakwar, Thamar Looser, Patricia Spitzli, Christel Herzog, Denis Villemagne, Yvonne Kaufmann, Alienor Auge, Martin Hänggi, Waleed Ali, Tamara Lekishvili, Teresa Frasconi, Stephan Wullschleger, Christof Zitt, Marco Franchini, Amelie Croset, Randall Watson, Vladimir Kirkin, Ursina Luethi, Adrian Ochsenbein, Carsten Riether, Daniel Steiner, Nicolas Leupin, Anne Goubier
Publikováno v:
Blood. 140:2251-2252
Autor:
Torsten Dreier, Sang We Kim, Christophe Borg, Peter Verheesen, Carla F. M. Molthoff, Philippe Barthélémy, Danielle J. Vugts, Paolo Michieli, Keunchil Park, Guus A.M.S. van Dongen, Luc Van Rompaey, Do Youn Oh, Natalie De Jonge, Karen Zwanenpoel, Christian Rolfo, Philippe Aftimos, Nicolas Leupin, Alain Thibault, Ahmad Awada, Sylvie Rottey, Valérie Hanssens, Julie Jacobs, Samson Fung, Patrick Pauwels, Hans de Haard, Anna Hultberg
Publikováno v:
Biomedicines
Biomedicines, Vol 9, Iss 665, p 665 (2021)
BIOMEDICINES
Biomedicines, 9(6). MDPI AG
Biomedicines, 9(6):665. MDPI AG
Biomedicines, 9 (6
Aftimos, P, Rolfo, C, Rottey, S, Barthélémy, P, Borg, C, Park, K, Oh, D-Y, Kim, S-W, de Jonge, N, Hanssens, V, Zwanenpoel, K, Molthoff, C, Vugts, D, Dreier, T, Verheesen, P, van Dongen, G A M S, Jacobs, J, van Rompaey, L, Hultberg, A, Michieli, P, Pauwels, P, Fung, S, Thibault, A, de Haard, H, Leupin, N & Awada, A 2021, ' The nhance® mutation-equipped anti-met antibody argx-111 displays increased tissue penetration and anti-tumor activity in advanced cancer patients ', Biomedicines, vol. 9, no. 6, 665 . https://doi.org/10.3390/biomedicines9060665
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 665, p 665 (2021)
BIOMEDICINES
Biomedicines, 9(6). MDPI AG
Biomedicines, 9(6):665. MDPI AG
Biomedicines, 9 (6
Aftimos, P, Rolfo, C, Rottey, S, Barthélémy, P, Borg, C, Park, K, Oh, D-Y, Kim, S-W, de Jonge, N, Hanssens, V, Zwanenpoel, K, Molthoff, C, Vugts, D, Dreier, T, Verheesen, P, van Dongen, G A M S, Jacobs, J, van Rompaey, L, Hultberg, A, Michieli, P, Pauwels, P, Fung, S, Thibault, A, de Haard, H, Leupin, N & Awada, A 2021, ' The nhance® mutation-equipped anti-met antibody argx-111 displays increased tissue penetration and anti-tumor activity in advanced cancer patients ', Biomedicines, vol. 9, no. 6, 665 . https://doi.org/10.3390/biomedicines9060665
Volume 9
Issue 6
Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase
Autor:
Analia Azaro, Jordi Rodon, Constanza Linossi, Richard D. Baird, Ulrike Fiedler, Simon Lord, Keith M. Dawson, Aurelius Omlin, Nicolas Leupin, Andreas Harstrick, Stefanie Fischer, Michael T. Stumpp, Christof Zitt, Mark R. Middleton, Adrian L. Harris
Publikováno v:
Journal of Clinical Oncology
PURPOSE A first-in-human study was performed with MP0250, a DARPin drug candidate. MP0250 specifically inhibits both vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) with the aim of disrupting the tumor microenvironment. P
Autor:
Adrian F. Ochsenbein, Ulrike Bacher, Hans de Haard, Ellen Erzeel, David Francisco, Anna Hultberg, Samson Fung, Magdalena Hinterbrandner, Markus G. Manz, Yara Banz, Mahan Moshir, Thomas Pabst, Tim Delahaye, Luc Van Rompaey, Sabine Höpner, Rouven Müller, Carsten Riether, Domenica Gandini, Walid H. Gharib, Rémy Bruggmann, Nicolas Leupin
Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist conventional chemotherapy and are the major cause of relapse1,2. Hypomethylating agents (HMAs) are the standard of care in the treatment of older or unfit patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bd75a7a31c6457437ffc638a812048
https://www.zora.uzh.ch/id/eprint/190892/
https://www.zora.uzh.ch/id/eprint/190892/