Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nicolas Lemus-Diaz"'
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.
Externí odkaz:
https://doaj.org/article/b66a7c73278d4acdb1a5947679641b80
Autor:
Daniel B. Hoffmann, Jens Gruber, Kai O. Böker, Delia Deppe, Stephan Sehmisch, Arndt F. Schilling, Nicolas Lemus-Diaz, Marina Komrakova, Stefan Schneider
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 443-452 (2018)
Rebalancing of the RANKL/OPG system seems to be an effective treatment strategy in postmenopausal osteoporosis. Here, we evaluate the knockdown of RANKL by in-vivo-delivered siRNA in a rat model of osteoporosis. Virus-like-particles (VLPs) derived fr
Externí odkaz:
https://doaj.org/article/b2670b6e41a94cd28c247725f8d7e110
Publikováno v:
Bio-Protocol, Vol 8, Iss 17 (2018)
MicroRNA-induced gene regulation is a growing field in basic and translational research. Examining this regulation directly in cells is necessary to validate high-throughput data originated from RNA sequencing technologies. For this several studies e
Externí odkaz:
https://doaj.org/article/56520bb23180447f9d206cc400c3e5f9
Publikováno v:
Trends in Biochemical Sciences. 47:596-608
Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936f5311b345de7559bb4054ae598eb1
https://doi.org/10.1016/j.tibs.2022.03.004
https://doi.org/10.1016/j.tibs.2022.03.004
Autor:
Nicole, Kleiber, Nicolas, Lemus-Diaz, Carina, Stiller, Marleen, Heinrichs, Mandy Mong-Quyen, Mai, Philipp, Hackert, Ricarda, Richter-Dennerlein, Claudia, Höbartner, Katherine E, Bohnsack, Markus T, Bohnsack
Publikováno v:
Nature Communications
Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m3C32 in the human mitochondrial (mt-)t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad1fbf0e95915065a0be5efabf499a99
https://pubmed.ncbi.nlm.nih.gov/35017528
https://pubmed.ncbi.nlm.nih.gov/35017528
Autor:
Lara Timantra Schiller, Nicolas Lemus-Diaz, Jens Gruber, Kai O. Böker, Rafael Rinaldi Ferreira
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 278-287 (2018)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Research on cell-free vesicles revealed a multitude of characteristics, in particular of microvesicles and exosomes, that range from their potential as biomarkers to a function in horizontal transfer of genetic information from cell to cell and also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aee9ea01d7de4c12509758045b86d21
https://doi.org/10.1016/j.omtm.2018.03.008
https://doi.org/10.1016/j.omtm.2018.03.008
Publikováno v:
Bio Protoc
MicroRNA-induced gene regulation is a growing field in basic and translational research. Examining this regulation directly in cells is necessary to validate high-throughput data originated from RNA sequencing technologies. For this several studies e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c302a0eb5b8f46a0f414ef0fce98c8
https://europepmc.org/articles/PMC8328604/
https://europepmc.org/articles/PMC8328604/
Autor:
Jens Gruber, Nicolas Lemus-Diaz, Stefan Schneider, Lara Timantra Schiller, Rafael Rinaldi Ferreira, Kai O. Böker
Efficient transduction tools are a hallmark for both research and therapy development. Here, we introduce new insights into the generation of lentiviral vectors with improved performance by utilizing producer cells with increased production rates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab032aa3e3002bce48c73bff13e9f1b3
https://europepmc.org/articles/PMC5835022/
https://europepmc.org/articles/PMC5835022/
Autor:
Mónica Cruz-Barrera, Nathalia Flórez-Zapata, Nicolás Lemus-Diaz, Carlos Medina, Cristian-Camilo Galindo, Lorena-Xiomara González-Acero, Luz Correa, Bernardo Camacho, Jens Gruber, Gustavo Salguero
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mesenchymal stromal cells (MSC) have been used in over 800 clinical trials with encouraging results in the field of transplant medicine and chronic inflammatory diseases. Today, Umbilical Cord (UC)-derived MSC are the second leading source used for c
Externí odkaz:
https://doaj.org/article/69605a4a097b4505b68f7c1eacfff978
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m3C32 in the human mitochondrial (mt-)t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7f2d245cf6a953637192857a84e127